Domains within Homo sapiens protein Q15032-3

Isoform 3 of R3H domain-containing protein 1

Alternative representations: 1 /

Protein length1100 aa
Source databaseUniProt
Identifiers Q15032-3, ENSP00000387010.1, ENSP00000387010
Source gene ENSG00000048991
Alternative splicing Q15032-2, R3HD1_HUMAN, C9JIX3_HUMAN, Q15032-4, C9JIX1_HUMAN, Q15032-3, H7C2F9_HUMAN, H7C1X4_HUMAN, H7C207_HUMAN, H7BZ47_HUMAN, H7C3T7_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

Q15032-3 is shown as R3HDM1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for R3HDM1

Protein Q15032-3 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04320Dorso-ventral axis formation

KEGG orthologous groups

KONameDescription
K23713STAC3SH3 and cysteine-rich domain-containing protein 3

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000387010 in eggNOG.

OGTaxonomic classDescription
LKOG2953All organisms (root)SH3 and cysteine-rich domain-containing protein 3,a component of the cytoplasm (encore),SH3 and cysteine-rich domain-containing protein 2
KOG2953Eukaryota (superkingdom)SH3 and cysteine-rich domain-containing protein 3,a component of the cytoplasm (encore),SH3 and cysteine-rich domain-containing protein 2
HW51FMetazoa (kingdom)SH3 and cysteine-rich domain-containing protein 2,SH3 and cysteine-rich domain-containing protein 3,a component of the cytoplasm (encore)
93V6FChordata (phylum)SH3 and cysteine-rich domain-containing protein 3
5R7MYSarcopterygii (superclass)R3H,SUZ
8ZNU7Mammalia (class)R3H,SUZ
4R52AEuarchontoglires (superorder)R3H,SUZ
4ZTP0Primates (order)SUZ,R3H
987IHHaplorrhini (suborder)SUZ,R3H
BVABFSimiiformes (infraorder)R3H,SUZ
9EVGICatarrhini (parvorder)R3H,SUZ
H3D48Bilateria (clade)SH3 and cysteine-rich domain-containing protein 2,SH3 and cysteine-rich domain-containing protein 3,a component of the cytoplasm (encore)
7MSG5Opisthokonta (clade)SH3 and cysteine-rich domain-containing protein 2,SH3 and cysteine-rich domain-containing protein 3,a component of the cytoplasm (encore)
9GS1XVertebrata (clade)SH3 and cysteine-rich domain-containing protein 3
FX35XHominoidea (superfamily)R3H,SUZ
5N47WHominidae (family)R3H,SUZ
5Y10NHomininae (subfamily)R3H,SUZ

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: