Domains within Drosophila melanogaster protein Q24270-4

Isoform C of Voltage-dependent calcium channel type D subunit alpha-1

Alternative representations: 1 /

Protein length2552 aa
Source databaseUniProt
Identifiers Q24270-4, FBPP0089047, M9PDI5_DROME, M9PDI5
Source gene FBgn0001991
Alternative splicing M9PBC0_DROME, Q24270-2, Q24270-4, FBpp0304341, FBpp0304337, M9PFZ4_DROME, CAC1D_DROME, Q24270-3, M9PDI1_DROME, FBpp0304340

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

Q24270-4 is shown as Ca-alpha1D in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ca-alpha1D

Protein Q24270-4 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04010MAPK signaling pathway
map04921Oxytocin signaling pathway
map04020Calcium signaling pathway

KEGG orthologous groups

KONameDescription
K04851CACNA1D, CAV1.3voltage-dependent calcium channel L type alpha-1D
K04849CACNA1B, CAV2.2voltage-dependent calcium channel N type alpha-1B
K04834SCN2A, NAV1.2voltage-gated sodium channel type II alpha

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 22 PTMs annotated in this protein:

PTMCount
Phosphorylation18
Acetylation3
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Ca-alpha1D.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0089047 in eggNOG.

OGTaxonomic classDescription
LKOG2301All organisms (root)voltage-gated sodium channel type II alpha,tetratricopeptide repeat protein 21B,sodium leak channel non-selective protein
FDYN9melanogaster subgroup (species subgroup)voltage-dependent calcium channel L type alpha-1D
FV1SFmelanogaster group (species group)voltage-dependent calcium channel L type alpha-1D
EJDGHEndopterygota (cohort)voltage-dependent calcium channel N type alpha-1B,voltage-dependent calcium channel L type alpha-1D,two pore calcium channel protein 1
KOG2301Eukaryota (superkingdom)voltage-gated sodium channel type II alpha,tetratricopeptide repeat protein 21B,sodium leak channel non-selective protein
HUDKQMetazoa (kingdom)voltage-gated sodium channel type II alpha,voltage-dependent calcium channel L type alpha-1D,voltage-dependent calcium channel N type alpha-1B
HIHEKArthropoda (phylum)voltage-dependent calcium channel L type alpha-1D,voltage-dependent calcium channel N type alpha-1B,two pore calcium channel protein 1
85W4IHexapoda (subphylum)voltage-dependent calcium channel N type alpha-1B,voltage-dependent calcium channel L type alpha-1D,two pore calcium channel protein 1
AHBZPNeoptera (infraclass)voltage-dependent calcium channel N type alpha-1B,voltage-dependent calcium channel L type alpha-1D,two pore calcium channel protein 1
ANGJVDiptera (order)voltage-dependent calcium channel N type alpha-1B,voltage-dependent calcium channel L type alpha-1D
7J97SOpisthokonta (clade)voltage-gated sodium channel type II alpha,sodium leak channel non-selective protein,voltage-dependent calcium channel L type alpha-1D
H43EGBilateria (clade)voltage-gated sodium channel type II alpha,voltage-dependent calcium channel L type alpha-1D,voltage-dependent calcium channel N type alpha-1B
EH50RDrosophila (genus)voltage-dependent calcium channel L type alpha-1D
50BC3Sophophora (subgenus)voltage-dependent calcium channel L type alpha-1D

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: