Domains within Mus musculus protein Q61730-3

Isoform 3 of Interleukin-1 receptor accessory protein

Alternative representations: 1 /

Protein length685 aa
Source databaseUniProt
Identifiers Q61730-3, ENSMUSP00000093843.2, ENSMUSP00000093843
Source gene ENSMUSG00000022514
Alternative splicing Q61730-3, ENSMUSP00000128100.2, Q3UEL3_MOUSE, IL1AP_MOUSE, G3UY13_MOUSE, G3XA78_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

Q61730-3 is shown as Il1rap in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Il1rap

Protein Q61730-3 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05010Alzheimer disease
map04750Inflammatory mediator regulation of TRP channels

KEGG orthologous groups

KONameDescription
K02165DKK1_2_4dickkopf 1/2/4
K04723IL1RAPinterleukin 1 receptor accessory protein

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 2 PTMs annotated in this protein:

PTMCount
Phosphorylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Il1rap.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000093843 in eggNOG.

OGTaxonomic classDescription
LKOG1218All organisms (root)dickkopf 1/2/4,multiple epidermal growth factor-like domains protein 10/11,dickkopf 3
KOG1218Eukaryota (superkingdom)dickkopf 1/2/4,multiple epidermal growth factor-like domains protein 10/11,dickkopf 3
HUV12Metazoa (kingdom)interleukin 1 receptor accessory protein
94ABXChordata (phylum)interleukin 1 receptor accessory protein
5QEV8Sarcopterygii (superclass)interleukin 1 receptor accessory protein
8ZGZXMammalia (class)interleukin 1 receptor accessory protein
4R64VEuarchontoglires (superorder)interleukin 1 receptor accessory protein
AI83VRodentia (order)interleukin 1 receptor accessory protein
8D5JQMyomorpha (suborder)interleukin 1 receptor accessory protein
7JG2UOpisthokonta (clade)interleukin 1 receptor accessory protein
H4EW9Bilateria (clade)interleukin 1 receptor accessory protein
9FECHVertebrata (clade)interleukin 1 receptor accessory protein
CQ379Muridae (family)interleukin 1 receptor accessory protein
ADWU2Murinae (subfamily)interleukin 1 receptor accessory protein
5PRS5Mus (genus)interleukin 1 receptor accessory protein
HE9GRMus (subgenus)interleukin 1 receptor accessory protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: