Domains within Mus musculus protein Q6AXD2_MOUSE (Q6AXD2)

Abi2 protein

Alternative representations: 1 /

Protein length487 aa
Source databaseUniProt
Identifiers Q6AXD2_MOUSE, Q6AXD2, ENSMUSP00000140274.1, ENSMUSP00000140274
Source gene ENSMUSG00000026782
Alternative splicing ABI2_MOUSE, A0A087WRS3_MOUSE, Q6AXD2_MOUSE, Q6AXH6_MOUSE, A0A087WR90_MOUSE, A0A087WPP8_MOUSE, A0A087WNT3_MOUSE, A0A087WP64_MOUSE, A0A087WNU9_MOUSE, A0A087WPE6_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

Q6AXD2_MOUSE is shown as Abi2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Abi2

Protein Q6AXD2_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05132Salmonella infection
map05100Bacterial invasion of epithelial cells
map04810Regulation of actin cytoskeleton

KEGG orthologous groups

KONameDescription
K05751ABI2abl interactor 2
K13736ARHGAP10Rho GTPase-activating protein 10
K23649ABI1abl interactor 1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000140274 in eggNOG.

OGTaxonomic classDescription
LKOG2546All organisms (root)Rho GTPase-activating protein 10,abl interactor 2,abi gene family member 3
KOG2546Eukaryota (superkingdom)Rho GTPase-activating protein 10,abl interactor 2,abi gene family member 3
HURAXMetazoa (kingdom)abl interactor 2,abl interactor 1
93PRUChordata (phylum)abl interactor 1,abl interactor 2
5QZGCSarcopterygii (superclass)abl interactor 2
8Z6ACMammalia (class)abl interactor 2
4RATDEuarchontoglires (superorder)abl interactor 2
AI5I2Rodentia (order)Abi_HHR,SH3_1
8D8Y7Myomorpha (suborder)Abi_HHR,SH3_1
H4I12Bilateria (clade)abl interactor 2,abl interactor 1
7H4KNOpisthokonta (clade)abl interactor 2,abl interactor 1,abi gene family member 3
9G0VPVertebrata (clade)abl interactor 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: