Domains within Danio rerio protein Q803F0_DANRE (Q803F0)

TGFB-induced factor

Alternative representations: 1 /

Protein length273 aa
Source databaseUniProt
Identifiers Q803F0_DANRE, Q803F0, ENSDARP00000076869.4, ENSDARP00000076869, R4GEZ0_DANRE, R4GEZ0
Source gene ENSDARG00000059337
Alternative splicing F8W267_DANRE, ENSDARP00000127055.1, Q803F0_DANRE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

Q803F0_DANRE is shown as tgif1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for tgif1

Protein Q803F0_DANRE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04350TGF-beta signaling pathway

KEGG orthologous groups

KONameDescription
K19383TGIF1homeobox protein TGIF1
K24889IRXiroquois-class homeodomain protein IRX
K24891PKNOXhomeobox protein PKNOX

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 6 PTMs annotated in this protein:

PTMCount
Phosphorylation6

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein tgif1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7955.ENSDARP00000076869 in eggNOG.

OGTaxonomic classDescription
9IBPGOtomorpha (cohort)homeobox protein TGIF1
LKOG0773All organisms (root)iroquois-class homeodomain protein IRX,homeobox protein PKNOX,homeobox protein Mohawk
KOG0773Eukaryota (superkingdom)iroquois-class homeodomain protein IRX,homeobox protein PKNOX,homeobox protein Mohawk
HUZ9VMetazoa (kingdom)homeobox protein PKNOX,homeobox protein TGIF1,homeobox protein TGIF2
9422AChordata (phylum)homeobox protein TGIF2,homeobox protein TGIF1,homeobox protein TGIF2L
FXXJ2Actinopterygii (superclass)homeobox protein TGIF1,homeobox protein TGIF2
8NQ5TNeopterygii (subclass)homeobox protein TGIF1,homeobox protein TGIF2
9FN49Vertebrata (clade)homeobox protein TGIF2,homeobox protein TGIF1,homeobox protein TGIF2L
H3GCABilateria (clade)homeobox protein PKNOX,homeobox protein TGIF1,homeobox protein TGIF2
7KV3FOpisthokonta (clade)homeobox protein PKNOX,homeobox protein TGIF1,homeobox protein TGIF2
BEK2ACyprinidae (family)homeobox protein TGIF1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: