Domains within Mus musculus protein Q8BRF1_MOUSE (Q8BRF1)

Paired box protein Pax-3

Alternative representations: 1 /

Protein length484 aa
Source databaseUniProt
Identifiers Q8BRF1_MOUSE, Q8BRF1, ENSMUSP00000004994.9, ENSMUSP00000004994
Source gene ENSMUSG00000004872
Alternative splicing PAX3_MOUSE, Q8BRF1_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Metazoa

Predicted functional partners

Q8BRF1_MOUSE is shown as Pax3 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Pax3

Protein Q8BRF1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05202Transcriptional misregulation in cancer

KEGG orthologous groups

KONameDescription
K09381PAX3_7paired box protein 3/7

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000004994 in eggNOG.

OGTaxonomic classDescription
LKOG0849All organisms (root)paired box protein 3/7,paired box protein 6,zinc fingers and homeoboxes protein 3
KOG0849Eukaryota (superkingdom)paired box protein 3/7,paired box protein 6,zinc fingers and homeoboxes protein 3
HUAUNMetazoa (kingdom)paired box protein 3/7,paired box protein 6,paired box protein 4
94EFZChordata (phylum)paired box protein 3/7
5RC6ZSarcopterygii (superclass)paired box protein 3/7
8ZH8XMammalia (class)paired box protein 3/7
4RH7REuarchontoglires (superorder)paired box protein 3/7
AIBY0Rodentia (order)paired box protein 3/7
8DCCNMyomorpha (suborder)paired box protein 3/7
9FI80Vertebrata (clade)paired box protein 3/7
H3U18Bilateria (clade)paired box protein 3/7
7ICJ4Opisthokonta (clade)paired box protein 3/7,paired box protein 6,mitochondrial import inner membrane translocase subunit TIM54
CQC28Muridae (family)paired box protein 3/7
ADW0NMurinae (subfamily)paired box protein 3/7
5PJSNMus (genus)paired box protein 3/7
HE0JBMus (subgenus)paired box protein 3/7

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: