Domains within Homo sapiens protein Q8N1I0-3

Isoform 3 of Dedicator of cytokinesis protein 4

Alternative representations: 1 /

Protein length1975 aa
Source databaseUniProt
Identifiers Q8N1I0-3, ENSP00000410746.1, ENSP00000410746
Source gene ENSG00000128512
Alternative splicing H0Y7H7_HUMAN, Q8N1I0-3, DOCK4_HUMAN, H0Y599_HUMAN, F8WES4_HUMAN, C9J7D9_HUMAN, ENSP00000406468.1, ENSP00000403504.1, F5GXW1_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

Q8N1I0-3 is shown as DOCK4 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for DOCK4

Protein Q8N1I0-3 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04510Focal adhesion
map05171Coronavirus disease - COVID-19
map03010Ribosome
map04015Rap1 signaling pathway

KEGG orthologous groups

KONameDescription
K05727DOCK3dedicator of cytokinesis protein 3
K02936RP-L7Ae, RPL7Alarge subunit ribosomal protein L7Ae
K17697DOCK4dedicator of cytokinesis protein 4

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000410746 in eggNOG.

OGTaxonomic classDescription
LCOG1358All organisms (root)large subunit ribosomal protein L7Ae,small subunit ribosomal protein S12e,U4/U6 small nuclear ribonucleoprotein SNU13
LKOG1998All organisms (root)dedicator of cytokinesis protein 3,clarin,dedicator of cytokinesis protein 1
KOG3166Eukaryota (superkingdom)large subunit ribosomal protein L7Ae,dedicator of cytokinesis protein 4,dedicator of cytokinesis protein 3
KOG1998Eukaryota (superkingdom)dedicator of cytokinesis protein 3,clarin,dedicator of cytokinesis protein 1
HVYPPMetazoa (kingdom)dedicator of cytokinesis protein 4,dedicator of cytokinesis protein 3,dedicator of cytokinesis protein 1
949BSChordata (phylum)dedicator of cytokinesis protein 4
5QQQBSarcopterygii (superclass)dedicator of cytokinesis protein 4
8Z099Mammalia (class)dedicator of cytokinesis protein 4
4RHHMEuarchontoglires (superorder)dedicator of cytokinesis protein 4
50327Primates (order)dedicator of cytokinesis protein 4
98N8DHaplorrhini (suborder)dedicator of cytokinesis protein 4
BUY5FSimiiformes (infraorder)dedicator of cytokinesis protein 4
9F2C1Catarrhini (parvorder)dedicator of cytokinesis protein 4
7GPU0Opisthokonta (clade)dedicator of cytokinesis protein 4,dedicator of cytokinesis protein 3,dedicator of cytokinesis protein 1
H5XRABilateria (clade)dedicator of cytokinesis protein 4,dedicator of cytokinesis protein 3
9G540Vertebrata (clade)dedicator of cytokinesis protein 4
FXFCHHominoidea (superfamily)dedicator of cytokinesis protein 4
5N89ZHominidae (family)dedicator of cytokinesis protein 4
5XUA4Homininae (subfamily)dedicator of cytokinesis protein 4

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: