Domains within Homo sapiens protein Q96PY5-3

Isoform 2 of Formin-like protein 2

Alternative representations: 1 /

Protein length1092 aa
Source databaseUniProt
Identifiers Q96PY5-3, ENSP00000288670.9, ENSP00000288670
Source gene ENSG00000157827
Alternative splicing Q96PY5-3, C9IZY8_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

Q96PY5-3 is shown as FMNL2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for FMNL2

Protein Q96PY5-3 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map01240Biosynthesis of cofactors

KEGG orthologous groups

KONameDescription
K23957FMNLformic-like protein

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 45 PTMs annotated in this protein:

PTMCount
Phosphorylation29
Ubiquitination13
Methylation2
Myristoylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein FMNL2.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000288670 in eggNOG.

OGTaxonomic classDescription
LKOG1923All organisms (root)formic-like protein,protein fantom,X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
KOG1923Eukaryota (superkingdom)formic-like protein,protein fantom,X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
HUTZFMetazoa (kingdom)formic-like protein
93YWUChordata (phylum)formic-like protein
5R29FSarcopterygii (superclass)formic-like protein
8ZMNUMammalia (class)formic-like protein
4RIGDEuarchontoglires (superorder)formic-like protein
5027VPrimates (order)formic-like protein
98BJEHaplorrhini (suborder)formic-like protein
BVCCZSimiiformes (infraorder)formic-like protein
9ENWECatarrhini (parvorder)formic-like protein
H3F43Bilateria (clade)formic-like protein
7NB61Opisthokonta (clade)formic-like protein
9FB4PVertebrata (clade)formic-like protein
FX1KWHominoidea (superfamily)formic-like protein
5NDSPHominidae (family)formic-like protein
5Y42SHomininae (subfamily)formic-like protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: