Domains within Homo sapiens protein Q96RT1-8

Isoform 8 of Erbin

Alternative representations: 1 /

Protein length1419 aa
Source databaseUniProt
Identifiers Q96RT1-8, ENSP00000426632.1, ENSP00000426632
Source gene ENSG00000112851
Alternative splicing ERBIN_HUMAN, Q96RT1-2, B4DIP2_HUMAN, Q96RT1-4, Q96RT1-9, Q96RT1-8, Q96RT1-7, H0YA04_HUMAN, H0Y9E8_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

Q96RT1-8 is shown as ERBIN in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ERBIN

Protein Q96RT1-8 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04014Ras signaling pathway
map04621NOD-like receptor signaling pathway
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K22038LRRC8volume-regulated anion channel
K12796ERBIN, ERBB2IPerbb2-interacting protein
K19613SHOC2, SUR8leucine-rich repeat protein SHOC2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000426632 in eggNOG.

OGTaxonomic classDescription
LCOG1552All organisms (root)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,protein phosphatase 1 regulatory subunit 7
KOG0619Eukaryota (superkingdom)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,leucine-rich repeat transmembrane protein FLRT
HV7S4Metazoa (kingdom)leucine-rich repeat protein SHOC2,erbb2-interacting protein,protein scribble
94A2FChordata (phylum)leucine-rich repeat-containing protein 7,erbb2-interacting protein
5QBGJSarcopterygii (superclass)leucine-rich repeat-containing protein 7,erbb2-interacting protein
8Z1NEMammalia (class)erbb2-interacting protein
4R33SEuarchontoglires (superorder)erbb2-interacting protein
4ZZBDPrimates (order)erbb2-interacting protein
98Q58Haplorrhini (suborder)erbb2-interacting protein
BV85USimiiformes (infraorder)erbb2-interacting protein
9EWZ9Catarrhini (parvorder)erbb2-interacting protein
H5S1EBilateria (clade)leucine-rich repeat protein SHOC2,erbb2-interacting protein,protein scribble
7NB47Opisthokonta (clade)leucine-rich repeat protein SHOC2,erbb2-interacting protein,protein scribble
9FW4FVertebrata (clade)leucine-rich repeat-containing protein 7,erbb2-interacting protein
FXCGYHominoidea (superfamily)erbb2-interacting protein
5N48GHominidae (family)erbb2-interacting protein
5XZI9Homininae (subfamily)erbb2-interacting protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: