Domains within Homo sapiens protein Q9BYE0-2

Isoform 2 of Transcription factor HES-7

Alternative representations: 1 /

Protein length230 aa
Source databaseUniProt
Identifiers Q9BYE0-2, ENSP00000446205.2, ENSP00000446205
Source gene ENSG00000179111
Alternative splicing Q9BYE0-2, HES7_HUMAN, J3KSH6_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

Q9BYE0-2 is shown as HES7 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for HES7

Protein Q9BYE0-2 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05165Human papillomavirus infection

KEGG orthologous groups

KONameDescription
K09087HES2_6_7hairy and enhancer of split 2/6/7

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000446205 in eggNOG.

OGTaxonomic classDescription
LKOG4304All organisms (root)hairy and enhancer of split 2/6/7,hairy and enhancer of split related with YRPW motif,hairy and enhancer of split 5
KOG4304Eukaryota (superkingdom)hairy and enhancer of split 2/6/7,hairy and enhancer of split related with YRPW motif,hairy and enhancer of split 5
HUSH9Metazoa (kingdom)hairy and enhancer of split 2/6/7
94C1MChordata (phylum)hairy and enhancer of split 2/6/7
5R86ASarcopterygii (superclass)hairy and enhancer of split 2/6/7
8YXRPMammalia (class)hairy and enhancer of split 2/6/7
4R2S2Euarchontoglires (superorder)hairy and enhancer of split 2/6/7
4ZPNBPrimates (order)hairy and enhancer of split 2/6/7
98CWTHaplorrhini (suborder)hairy and enhancer of split 2/6/7
BUZ2ESimiiformes (infraorder)hairy and enhancer of split 2/6/7
9F0FYCatarrhini (parvorder)hairy and enhancer of split 2/6/7
7GCJDOpisthokonta (clade)hairy and enhancer of split 2/6/7
9FPGIVertebrata (clade)hairy and enhancer of split 2/6/7
H57FVBilateria (clade)hairy and enhancer of split 2/6/7
FX3ZPHominoidea (superfamily)hairy and enhancer of split 2/6/7
5N62RHominidae (family)hairy and enhancer of split 2/6/7
5Y1UTHomininae (subfamily)hairy and enhancer of split 2/6/7

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: