Domains within Homo sapiens protein Q9BZA8-2

Isoform 2 of Protocadherin-11 Y-linked

Alternative representations: 1 /

Protein length1048 aa
Source databaseUniProt
Identifiers Q9BZA8-2, ENSP00000355419.5, ENSP00000355419
Source gene ENSG00000099715
Alternative splicing Q9BZA8-3, A0A087WUC5_HUMAN, Q9BZA8-4, Q9BZA8-2, PC11Y_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

Q9BZA8-2 is shown as PCDH11Y in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for PCDH11Y

Protein Q9BZA8-2 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04391Hippo signaling pathway - fly
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K16499PCDHD2protocadherin delta 2

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 5 PTMs annotated in this protein:

PTMCount
Phosphorylation5

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSG00000099715.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000355419 in eggNOG.

OGTaxonomic classDescription
LKOG3594All organisms (root)protocadherin delta 2,protocadherin delta 1,protocadherin beta
KOG3594Eukaryota (superkingdom)protocadherin delta 2,protocadherin delta 1,protocadherin beta
HV0V3Metazoa (kingdom)protocadherin delta 2,protocadherin beta,protocadherin delta 1
947TZChordata (phylum)protocadherin delta 1
5QSQISarcopterygii (superclass)protocadherin delta 1
8Z4HXMammalia (class)protocadherin delta 1
4RNUBEuarchontoglires (superorder)protocadherin delta 1
4ZYZMPrimates (order)protocadherin delta 1
985REHaplorrhini (suborder)protocadherin delta 1
BVGE9Simiiformes (infraorder)protocadherin delta 1
9F120Catarrhini (parvorder)protocadherin delta 1
7HVIPOpisthokonta (clade)protocadherin delta 2,protocadherin delta 1,protocadherin beta
H59A0Bilateria (clade)protocadherin delta 2,protocadherin beta,protocadherin delta 1
9GBV8Vertebrata (clade)protocadherin delta 1
FXC8JHominoidea (superfamily)protocadherin delta 1
5N73CHominidae (family)protocadherin delta 1
5Y5ZBHomininae (subfamily)protocadherin delta 1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: