Domains within Mus musculus protein Q9DC83_MOUSE (Q9DC83)

Complement receptor 2

Alternative representations: 1 /

Protein length1032 aa
Source databaseUniProt
Identifiers Q9DC83_MOUSE, Q9DC83, ENSMUSP00000080938.3, ENSMUSP00000080938
Source gene ENSMUSG00000026616
Alternative splicing A0A0A6YWG3_MOUSE, ENSMUSP00000141706.1, A0A0A6YXU7_MOUSE, Q32M14_MOUSE, A0A1B0GS59_MOUSE, Q9DC83_MOUSE, ENSMUSP00000044261.8

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

Q9DC83_MOUSE is shown as Cr2 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Cr2

Protein Q9DC83_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04145Phagosome
map04610Complement and coagulation cascades

KEGG orthologous groups

KONameDescription
K06560MRC, CD206, CD280mannose receptor, C type
K04012CR2, CD21complement receptor type 2
K04002C4BPAcomplement component 4 binding protein alpha

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000080938 in eggNOG.

OGTaxonomic classDescription
LKOG4297All organisms (root)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
KOG4297Eukaryota (superkingdom)mannose receptor, C type,CUB and sushi domain-containing protein,E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
HSWIUMetazoa (kingdom)complement component 4 binding protein alpha,complement receptor type 2,complement component (3b/4b) receptor 1
94GKEChordata (phylum)complement component 4 binding protein alpha,complement receptor type 2,complement component (3b/4b) receptor 1
5QBVVSarcopterygii (superclass)complement component 4 binding protein alpha,complement receptor type 2,complement component (3b/4b) receptor 1
8Z64EMammalia (class)complement receptor type 2,complement component (3b/4b) receptor 1
4RCZ4Euarchontoglires (superorder)complement receptor type 2
AI98ERodentia (order)complement receptor type 2
8DH9CMyomorpha (suborder)complement receptor type 2
7K5YMOpisthokonta (clade)complement component 4 binding protein alpha,complement receptor type 2,complement component (3b/4b) receptor 1
H4P4BBilateria (clade)complement component 4 binding protein alpha,complement receptor type 2,complement component (3b/4b) receptor 1
9FYD7Vertebrata (clade)complement component 4 binding protein alpha,complement receptor type 2,complement component (3b/4b) receptor 1
CQ7SNMuridae (family)complement receptor type 2
ADXBWMurinae (subfamily)complement receptor type 2
5PMSUMus (genus)complement receptor type 2
HECVUMus (subgenus)complement receptor type 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: