Domains within Homo sapiens protein Q9HAV5-2

Isoform 2 of Tumor necrosis factor receptor superfamily member 27

Alternative representations: 1 /

Protein length318 aa
Source databaseUniProt
Identifiers Q9HAV5-2, ENSP00000253392.5, ENSP00000253392, ENSP00000379365.2, ENSP00000379365
Source gene ENSG00000131080
Alternative splicing TNR27_HUMAN, Q9HAV5-2

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

Q9HAV5-2 is shown as EDA2R in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for EDA2R

Protein Q9HAV5-2 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04064NF-kappa B signaling pathway
map04060Cytokine-cytokine receptor interaction

KEGG orthologous groups

KONameDescription
K05155TNFRSF19, TROYtumor necrosis factor receptor superfamily member 19
K05163EDA2R, TNFRSF27, XEDARtumor necrosis factor receptor superfamily member 27

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000379365 in eggNOG.

OGTaxonomic classDescription
713IFAll organisms (root)tumor necrosis factor receptor superfamily member 19,tumor necrosis factor receptor superfamily member 27,tumor necrosis factor receptor superfamily member 19-like
5GUP1Eukaryota (superkingdom)tumor necrosis factor receptor superfamily member 19,tumor necrosis factor receptor superfamily member 27,tumor necrosis factor receptor superfamily member 19-like
HSRY0Metazoa (kingdom)tumor necrosis factor receptor superfamily member 27,tumor necrosis factor receptor superfamily member 19
94JDMChordata (phylum)tumor necrosis factor receptor superfamily member 27,tumor necrosis factor receptor superfamily member 19
5QSE8Sarcopterygii (superclass)tumor necrosis factor receptor superfamily member 27
8Z86HMammalia (class)tumor necrosis factor receptor superfamily member 27
4RCEUEuarchontoglires (superorder)tumor necrosis factor receptor superfamily member 27
4ZPYNPrimates (order)tumor necrosis factor receptor superfamily member 27
986KBHaplorrhini (suborder)tumor necrosis factor receptor superfamily member 27
BV8SMSimiiformes (infraorder)tumor necrosis factor receptor superfamily member 27
9EGFFCatarrhini (parvorder)tumor necrosis factor receptor superfamily member 27
H4GQKBilateria (clade)tumor necrosis factor receptor superfamily member 27,tumor necrosis factor receptor superfamily member 19
9FWE9Vertebrata (clade)tumor necrosis factor receptor superfamily member 27,tumor necrosis factor receptor superfamily member 19
7IZJWOpisthokonta (clade)tumor necrosis factor receptor superfamily member 27,tumor necrosis factor receptor superfamily member 19
FWY07Hominoidea (superfamily)tumor necrosis factor receptor superfamily member 27
5ND5WHominidae (family)tumor necrosis factor receptor superfamily member 27
5Y0NVHomininae (subfamily)tumor necrosis factor receptor superfamily member 27

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: