Domains within Homo sapiens protein Q9HCH5-13

Isoform 10 of Synaptotagmin-like protein 2

Alternative representations: 1 /

Protein length935 aa
Source databaseUniProt
Identifiers Q9HCH5-13, ENSP00000318803.4, ENSP00000318803, ENSP00000352065.6, ENSP00000352065
Source gene ENSG00000137501
Alternative splicing E9PIB5_HUMAN, ENSP00000489095.1, Q9HCH5-13, ENSP00000432996.1, A0A0U1RRJ3_HUMAN, ENSP00000374608.3, ENSP00000488994.1, SYTL2_HUMAN, ENSP00000432144.1, Q9HCH5-14, A0A0U1RR07_HUMAN, Q9HCH5-6, E9PQL8_HUMAN, ENSP00000437005.1, ENSP00000432137.1, ENSP00000434111.1, ENSP00000431703.1, ENSP00000432116.1, ENSP00000434621.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

Q9HCH5-13 is shown as SYTL2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for SYTL2

Protein Q9HCH5-13 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04721Synaptic vesicle cycle
map04714Thermogenesis

KEGG orthologous groups

KONameDescription
K17598SYTLsynaptotagmin-like protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000318803 in eggNOG.

OGTaxonomic classDescription
LKOG1028All organisms (root)synaptotagmin-like protein,synaptotagmin-14/16,synaptotagmin-1
KOG1028Eukaryota (superkingdom)synaptotagmin-like protein,synaptotagmin-14/16,synaptotagmin-1
HVMI3Metazoa (kingdom)synaptotagmin-like protein,NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
94V0XChordata (phylum)synaptotagmin-like protein
5QRA4Sarcopterygii (superclass)synaptotagmin-like protein
8Z4K2Mammalia (class)synaptotagmin-like protein
4RC81Euarchontoglires (superorder)synaptotagmin-like protein
4ZYFXPrimates (order)synaptotagmin-like protein
989SHHaplorrhini (suborder)synaptotagmin-like protein
BVJ6FSimiiformes (infraorder)synaptotagmin-like protein
9EJRKCatarrhini (parvorder)synaptotagmin-like protein
H4UWABilateria (clade)synaptotagmin-like protein
7H9B5Opisthokonta (clade)synaptotagmin-like protein,NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
9GHI1Vertebrata (clade)synaptotagmin-like protein
FXEZKHominoidea (superfamily)synaptotagmin-like protein
5MZ67Hominidae (family)synaptotagmin-like protein
5XV9WHomininae (subfamily)synaptotagmin-like protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: