Domains within Drosophila melanogaster protein Q9W326_DROME (Q9W326)

FI18049p1

Alternative representations: 1 /

Protein length1426 aa
Source databaseUniProt
Identifiers Q9W326_DROME, Q9W326, FBPP0292725, H5V8D8
Source gene FBgn0261931
Alternative splicing Q9W325_DROME, D5SHR3_DROME, M9MS90_DROME, Q9W326_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

Q9W326_DROME is shown as CG42797 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CG42797

Protein Q9W326_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04120Ubiquitin mediated proteolysis

KEGG orthologous groups

KONameDescription
K12168HECW2E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
K04678SMURFE3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0292725 in eggNOG.

OGTaxonomic classDescription
EJ6ZBEndopterygota (cohort)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
LKOG0940All organisms (root)E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26],pleckstrin homology domain-containing family A member 4/5/6/7,E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
FV0KMmelanogaster group (species group)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
FE56Xmelanogaster subgroup (species subgroup)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
KOG0940Eukaryota (superkingdom)E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26],pleckstrin homology domain-containing family A member 4/5/6/7,E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
HW4HSMetazoa (kingdom)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26],E3 ubiquitin-protein ligase HECW1 [EC:2.3.2.26],E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
HI0CUArthropoda (phylum)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
85UZ6Hexapoda (subphylum)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
AGYPGNeoptera (infraclass)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
ANIS9Diptera (order)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
7HDHAOpisthokonta (clade)E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26],E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26],E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
H61SYBilateria (clade)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26],E3 ubiquitin-protein ligase HECW1 [EC:2.3.2.26],E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
EGV2ZDrosophila (genus)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]
50APMSophophora (subgenus)E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: