Domains within Homo sapiens protein Q9Y6N9-5

Isoform 5 of Harmonin

Alternative representations: 1 /

Protein length899 aa
Source databaseUniProt
Identifiers Q9Y6N9-5, ENSP00000005226.7, ENSP00000005226
Source gene ENSG00000006611
Alternative splicing Q9Y6N9-3, USH1C_HUMAN, ENSP00000432944.1, Q9Y6N9-4, Q9Y6N9-5, E9PNW1_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

Q9Y6N9-5 is shown as USH1C in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for USH1C

Protein Q9Y6N9-5 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04530Tight junction

KEGG orthologous groups

KONameDescription
K10692LNX1_2ligand of Numb protein X 1/2 [EC:2.3.2.27]

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 9 PTMs annotated in this protein:

PTMCount
Phosphorylation7
Acetylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein USH1C.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000005226 in eggNOG.

OGTaxonomic classDescription
LKOG3528All organisms (root)ligand of Numb protein X 1/2 [EC:2.3.2.27],syntenin-1,intraflagellar transport protein 20
KOG3528Eukaryota (superkingdom)ligand of Numb protein X 1/2 [EC:2.3.2.27],syntenin-1,intraflagellar transport protein 20
HV27WMetazoa (kingdom)harmonin
93I8DChordata (phylum)harmonin
5QPRRSarcopterygii (superclass)harmonin
8ZFABMammalia (class)harmonin
4R3RDEuarchontoglires (superorder)harmonin
501I4Primates (order)harmonin
98PNAHaplorrhini (suborder)harmonin
BVGCQSimiiformes (infraorder)harmonin
9EU96Catarrhini (parvorder)harmonin
9FY66Vertebrata (clade)harmonin
7K422Opisthokonta (clade)harmonin
H71NUBilateria (clade)harmonin
FX17HHominoidea (superfamily)harmonin
5N3KNHominidae (family)harmonin
5Y0CQHomininae (subfamily)harmonin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: