Domains within Mus musculus protein S4R1P5_MOUSE (S4R1P5)

Dystonin

Alternative representations: 1 /

Protein length7717 aa
Source databaseUniProt
Identifiers S4R1P5_MOUSE, S4R1P5, ENSMUSP00000138308.1, ENSMUSP00000138308
Source gene ENSMUSG00000026131
Alternative splicing S4R1P5_MOUSE, A0A087WRB8_MOUSE, A0A0A6YX28_MOUSE, A0A0A6YXR1_MOUSE, Q91ZU6-2, DYST_MOUSE, Q91ZU6-5, A0A087WPR7_MOUSE, A0A087WSP0_MOUSE, A0A1D5RLZ3_MOUSE, S4R1Y6_MOUSE, S4R2A8_MOUSE, S4R2C6_MOUSE, E9Q9X1_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Murinae

Predicted functional partners

S4R1P5_MOUSE is shown as Dst in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Dst

Protein S4R1P5_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04075Plant hormone signal transduction
map05412Arrhythmogenic right ventricular cardiomyopathy

KEGG orthologous groups

KONameDescription
K08235E2.4.1.207xyloglucan:xyloglucosyl transferase [EC:2.4.1.207]
K10382DSTdystonin
K10381DSPdesmoplakin

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000138308 in eggNOG.

OGTaxonomic classDescription
LKOG0516All organisms (root)xyloglucan:xyloglucosyl transferase [EC:2.4.1.207],growth arrest-specific protein 2,xyloglucan:xyloglucosyl transferase TCH4 [EC:2.4.1.207]
KOG0516Eukaryota (superkingdom)xyloglucan:xyloglucosyl transferase [EC:2.4.1.207],growth arrest-specific protein 2,xyloglucan:xyloglucosyl transferase TCH4 [EC:2.4.1.207]
HT8JHMetazoa (kingdom)dystonin,desmoplakin,plectin
93VW3Chordata (phylum)desmoplakin,plectin,dystonin
5R39XSarcopterygii (superclass)dystonin,desmoplakin,microtuble-actin crosslinking factor 1
8Z8YWMammalia (class)dystonin,microtuble-actin crosslinking factor 1
4RMTKEuarchontoglires (superorder)microtuble-actin crosslinking factor 1,dystonin
AI4Q1Rodentia (order)microtuble-actin crosslinking factor 1,dystonin
8DKAIMyomorpha (suborder)dystonin
7P53YOpisthokonta (clade)dystonin,envoplakin,periplakin
H5UUPBilateria (clade)dystonin,desmoplakin,plectin
9GJP3Vertebrata (clade)desmoplakin,plectin,dystonin
CQ7M7Muridae (family)dystonin
AE0HSMurinae (subfamily)dystonin
5PIHVMus (genus)dystonin
HE408Mus (subgenus)dystonin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: