Domains within Homo sapiens protein SUMO1_HUMAN (P63165)

Small ubiquitin-related modifier 1

Alternative representations: 1 /

Protein length101 aa
Source databaseUniProt
Identifiers SUMO1_HUMAN, P63165, ENSP00000376077.2, ENSP00000376077, ENSP00000376076.1, ENSP00000376076, A8MUS8, B2R4I5, P55856, Q6FGG0, Q6NZ62, Q93068, SUMO1_BOVIN, Q5E9D1, Q3ZC68, B8ZZ67_HUMAN, B8ZZ67, A0A0A0MXR0_PONAB, A0A0A0MXR0, A0A2J8N5C1_PANTR, A0A2J8N5C1, A0A2J8WUW1_PONAB, A0A2J8WUW1, A0A2K6U9F7_SAIBB, A0A2K6U9F7, A0A2K5YY45_MANLE, A0A2K5YY45, G1R5R3_NOMLE, G1R5R3, L5MC68_MYODS, L5MC68, SUMO1_MOUSE, P63166, Q3TX92, SUMO1_PIG, A7WLH8, SUMO1_PONAB, Q5R6J4, SUMO1_RAT, Q5I0H3, A0A024R3Z2_HUMAN, A0A024R3Z2, H9EMK4_MACMU, H9EMK4, F7HZB5_CALJA, F7HZB5, K7CF70_PANTR, K7CF70, B0M1N0_PIG, B0M1N0, I7G9I8_MACFA, I7G9I8, A0A2J8WUY8_PONAB, A0A2J8WUY8, G3S6X5_GORGO, G3S6X5, A0A2K6DP69_MACNE, A0A2K6DP69, A0A2K5MG21_CERAT, A0A2K5MG21, A0A2K6Q379_RHIRO, A0A2K6Q379, A0A2K5EBY3_AOTNA, A0A2K5EBY3, A0A2I3LR16_PAPAN, A0A2I3LR16, A0A2K6U9D7_SAIBB, A0A2K6U9D7, A0A2K6EKD7_PROCO, A0A2K6EKD7, A0A250XUY8_CASCN, A0A250XUY8
Source gene ENSG00000116030
Alternative splicing SUMO1_HUMAN, B8ZZN6_HUMAN, ENSP00000376075.3, B9A032_HUMAN, B8ZZJ0_HUMAN, ENSP00000386472.2, F8WBI1_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

SUMO1_HUMAN is shown as SUMO1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for SUMO1

Protein SUMO1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03013Nucleocytoplasmic transport

KEGG orthologous groups

KONameDescription
K12160SUMO, SMT3small ubiquitin-related modifier

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 28 PTMs annotated in this protein:

PTMCount
Phosphorylation10
SUMOylation7
Ubiquitination6
Isopeptide bond3
Acetylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein SUMO1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000376077 in eggNOG.

OGTaxonomic classDescription
LKOG1769All organisms (root)small ubiquitin-related modifier,kinetochore protein NNF1,uncharacterized protein
KOG1769Eukaryota (superkingdom)small ubiquitin-related modifier,kinetochore protein NNF1,uncharacterized protein
HV9VCMetazoa (kingdom)small ubiquitin-related modifier
93ECRChordata (phylum)small ubiquitin-related modifier
5QT01Sarcopterygii (superclass)small ubiquitin-related modifier
8ZHJ2Mammalia (class)small ubiquitin-related modifier
4RAN3Euarchontoglires (superorder)small ubiquitin-related modifier
503YKPrimates (order)small ubiquitin-related modifier
98QQMHaplorrhini (suborder)small ubiquitin-related modifier
BV2CZSimiiformes (infraorder)small ubiquitin-related modifier
9ESD8Catarrhini (parvorder)small ubiquitin-related modifier
9GHWSVertebrata (clade)small ubiquitin-related modifier
H4ZZWBilateria (clade)small ubiquitin-related modifier
7JG9VOpisthokonta (clade)small ubiquitin-related modifier
FX26NHominoidea (superfamily)small ubiquitin-related modifier
5N7RSHominidae (family)small ubiquitin-related modifier
5Y258Homininae (subfamily)small ubiquitin-related modifier

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: