Domains within Mus musculus protein TNR18_MOUSE (O35714)

Tumor necrosis factor receptor superfamily member 18

Alternative representations: 1 /

Protein length228 aa
Source databaseUniProt
Identifiers TNR18_MOUSE, O35714, ENSMUSP00000099462.3, ENSMUSP00000099462, Q9JKR1, Q9JKR2, Q9JKR3, Q540M6_MOUSE, Q540M6
Source gene ENSMUSG00000041954
Alternative splicing TNR18_MOUSE, O35714-4, B1ASL6_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

TNR18_MOUSE is shown as Tnfrsf18 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Tnfrsf18

Protein TNR18_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04060Cytokine-cytokine receptor interaction

KEGG orthologous groups

KONameDescription
K05152TNFRSF14, HVEM, CD270tumor necrosis factor receptor superfamily member 14
K05154TNFRSF18, GITR, CD357tumor necrosis factor receptor superfamily member 18

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000099462 in eggNOG.

OGTaxonomic classDescription
781TWAll organisms (root)tumor necrosis factor receptor superfamily member 14,tumor necrosis factor receptor superfamily member 11B,tumor necrosis factor receptor superfamily member 5
5F5WKEukaryota (superkingdom)tumor necrosis factor receptor superfamily member 14,tumor necrosis factor receptor superfamily member 11B,tumor necrosis factor receptor superfamily member 5
HTJYRMetazoa (kingdom)tumor necrosis factor receptor superfamily member 18
94S2KChordata (phylum)tumor necrosis factor receptor superfamily member 18
5R2QRSarcopterygii (superclass)tumor necrosis factor receptor superfamily member 18
8ZEAGMammalia (class)tumor necrosis factor receptor superfamily member 18
4RPCDEuarchontoglires (superorder)tumor necrosis factor receptor superfamily member 18
AI29ZRodentia (order)tumor necrosis factor receptor superfamily member 18
8D4HIMyomorpha (suborder)tumor necrosis factor receptor superfamily member 18
H3W53Bilateria (clade)tumor necrosis factor receptor superfamily member 18
7N4JNOpisthokonta (clade)tumor necrosis factor receptor superfamily member 18
9FN2KVertebrata (clade)tumor necrosis factor receptor superfamily member 18
CQ7G6Muridae (family)tumor necrosis factor receptor superfamily member 18
AE9CQMurinae (subfamily)tumor necrosis factor receptor superfamily member 18
5PR9QMus (genus)tumor necrosis factor receptor superfamily member 18
HECJUMus (subgenus)tumor necrosis factor receptor superfamily member 18

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: