Domains within Homo sapiens protein UPI000BAE54E9

leucine-rich repeat-containing protein 9

Alternative representations: 1 /

Protein length1494 aa
Source databaseUniProt
Identifiers UPI000BAE54E9, ENSP00000493790.1, ENSP00000493790
Source gene ENSG00000131951
Alternative splicing LRRC9_HUMAN, Q6ZRR7-2, UPI000BAE54E9, ENSP00000457773.1, H3BUB1_HUMAN, ENSP00000494624.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

UPI000BAE54E9 is shown as LRRC9 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for LRRC9

Protein UPI000BAE54E9 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04921Oxytocin signaling pathway
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K22038LRRC8volume-regulated anion channel
K17550PPP1R7, SDS22protein phosphatase 1 regulatory subunit 7

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000493790 in eggNOG.

OGTaxonomic classDescription
LCOG1552All organisms (root)volume-regulated anion channel,leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein,protein phosphatase 1 regulatory subunit 7
KOG0531Eukaryota (superkingdom)protein phosphatase 1 regulatory subunit 7,dynein axonemal light chain 1,dynein axonemal assembly factor 11
HW99IMetazoa (kingdom)LRR_9,LRR_8,LRR_4
93PNBChordata (phylum)LRR_4,LRR_8,LRR_9
5QH13Sarcopterygii (superclass)LRR_4,LRR_8,LRR_9
8YX43Mammalia (class)LRR_4,LRR_8,LRR_9
4RDCIEuarchontoglires (superorder)LRR_4,LRR_8,LRR_9
4ZNDBPrimates (order)LRR_4,LRR_8,LRR_9
98RTQHaplorrhini (suborder)LRR_4,LRR_9,LRR_8
BV6S6Simiiformes (infraorder)LRR_4,LRR_9,LRR_8
9EMKCCatarrhini (parvorder)LRR_4,LRR_9,LRR_8
7IY57Opisthokonta (clade)LRR_9,LRR_8,LRR_4
9GEIHVertebrata (clade)LRR_4,LRR_8,LRR_9
H5CEFBilateria (clade)LRR_9,LRR_8,LRR_4
FX3YPHominoidea (superfamily)LRR_4,LRR_9,LRR_8
5MY99Hominidae (family)LRR_4,LRR_8,LRR_9
5XTFJHomininae (subfamily)LRR_4,LRR_8,LRR_9

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: