Domains within Drosophila melanogaster protein WGN_DROME (Q9VWS4)

Tumor necrosis factor receptor superfamily member wengen

Alternative representations: 1 /

Protein length343 aa
Source databaseUniProt
Identifiers WGN_DROME, Q9VWS4, FBPP0074388, Q7Z1X1
Source gene FBgn0030941
Alternative splicing WGN_DROME, X2JCG6_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

WGN_DROME is shown as wgn in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for wgn

Protein WGN_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03410Base excision repair
map04215Apoptosis - multiple species
map03030DNA replication

KEGG orthologous groups

KONameDescription
K16679WGNwengen
K10747LIG1DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0074388 in eggNOG.

OGTaxonomic classDescription
EIWJHEndopterygota (cohort)wengen,DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
FV05Hmelanogaster group (species group)wengen
FDYDImelanogaster subgroup (species subgroup)wengen
LCOG1793All organisms (root)DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7],bifunctional non-homologous end joining protein LigD [EC:6.5.1.1],DNA ligase 4 [EC:6.5.1.1]
KOG0967Eukaryota (superkingdom)DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7],wengen,DNA ligase 4 [EC:6.5.1.1]
HTKCZMetazoa (kingdom)DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7],wengen
HIAKUArthropoda (phylum)DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7],wengen
85ID2Hexapoda (subphylum)wengen,DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
AH6PYNeoptera (infraclass)wengen,DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
ANWEFDiptera (order)wengen,DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
7GYUAOpisthokonta (clade)DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7],wengen
H3WJBBilateria (clade)DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7],wengen
EH4URDrosophila (genus)wengen
50M0TSophophora (subgenus)wengen

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: