Domains within Drosophila melanogaster protein X2JCF3_DROME (X2JCF3)

Rho GTPase activating protein at 16F, isoform E

Alternative representations: 1 /

Protein length581 aa
Source databaseUniProt
Identifiers X2JCF3_DROME, X2JCF3, FBPP0309969
Source gene FBgn0030893
Alternative splicing Q9VWY8_DROME, X2JCF3_DROME

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

X2JCF3_DROME is shown as RhoGAP16F in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RhoGAP16F

Protein X2JCF3_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04011MAPK signaling pathway - yeast

KEGG orthologous groups

KONameDescription
K20636ARHGAP12_27Rho GTPase-activating protein 12/27

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0309969 in eggNOG.

OGTaxonomic classDescription
EJ45SEndopterygota (cohort)Rho GTPase-activating protein 15
FE12Dmelanogaster subgroup (species subgroup)Rho GTPase-activating protein 15
FV2ZMmelanogaster group (species group)Rho GTPase-activating protein 15
LKOG1450All organisms (root)Rho GTPase-activating protein 12/27,Rho GTPase-activating protein 15,Rho GTPase-activating protein SYDE
KOG1450Eukaryota (superkingdom)Rho GTPase-activating protein 12/27,Rho GTPase-activating protein 15,Rho GTPase-activating protein SYDE
HVGM4Metazoa (kingdom)Rho GTPase-activating protein 15
HIRIRArthropoda (phylum)Rho GTPase-activating protein 15
85MGZHexapoda (subphylum)Rho GTPase-activating protein 15
AHI7PNeoptera (infraclass)Rho GTPase-activating protein 15
ANDAQDiptera (order)Rho GTPase-activating protein 15
7N7N0Opisthokonta (clade)Rho GTPase-activating protein 15
H51JJBilateria (clade)Rho GTPase-activating protein 15
EGYUUDrosophila (genus)Rho GTPase-activating protein 15
50H4ISophophora (subgenus)Rho GTPase-activating protein 15

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: