Domains within Homo sapiens protein ZBT10_HUMAN (Q96DT7)

Zinc finger and BTB domain-containing protein 10

Alternative representations: 1 /

Protein length871 aa
Source databaseUniProt
Identifiers ZBT10_HUMAN, Q96DT7, ENSP00000387462.1, ENSP00000387462, ENSP00000412036.3, ENSP00000412036, A4FVD0, Q86W96, Q8IXI9, Q96MH9, Q96DT7-3
Source gene ENSG00000205189
Alternative splicing ENSP00000368384.4, ZBT10_HUMAN, Q96DT7-2, ENSP00000484716.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

ZBT10_HUMAN is shown as ZBTB10 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ZBTB10

Protein ZBT10_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05202Transcriptional misregulation in cancer
map05168Herpes simplex virus 1 infection

KEGG orthologous groups

KONameDescription
K10518ZBTB47zinc finger and BTB domain-containing protein 47
K09228KRABKRAB domain-containing zinc finger protein

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 8 PTMs annotated in this protein:

PTMCount
Phosphorylation5
Methylation2
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ZBTB10.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000387462 in eggNOG.

OGTaxonomic classDescription
LKOG1721All organisms (root)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
KOG1721Eukaryota (superkingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
HU1A6Metazoa (kingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,IKAROS family zinc finger protein
94RCAChordata (phylum)zinc finger and BTB domain-containing protein 47,myoneurin,zinc finger and BTB domain-containing protein 46
5QMPFSarcopterygii (superclass)zinc finger and BTB domain-containing protein 46,zinc finger and BTB domain-containing protein 10
8ZCVJMammalia (class)zinc finger and BTB domain-containing protein 10
4RAPBEuarchontoglires (superorder)zinc finger and BTB domain-containing protein 10
4ZU6ZPrimates (order)zinc finger and BTB domain-containing protein 10
98HRAHaplorrhini (suborder)zinc finger and BTB domain-containing protein 10
BUY4YSimiiformes (infraorder)zinc finger and BTB domain-containing protein 10
9EHK7Catarrhini (parvorder)zinc finger and BTB domain-containing protein 10
9GE85Vertebrata (clade)zinc finger and BTB domain-containing protein 47,myoneurin,zinc finger and BTB domain-containing protein 46
H663FBilateria (clade)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,IKAROS family zinc finger protein
7MTDYOpisthokonta (clade)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
FWZ65Hominoidea (superfamily)zinc finger and BTB domain-containing protein 10
5MYRNHominidae (family)zinc finger and BTB domain-containing protein 10
5Y1ZBHomininae (subfamily)zinc finger and BTB domain-containing protein 10

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: