Domains within Homo sapiens protein ZBT34_HUMAN (Q8NCN2)

Zinc finger and BTB domain-containing protein 34

Alternative representations: 1 /

Protein length500 aa
Source databaseUniProt
Identifiers ZBT34_HUMAN, Q8NCN2, ENSP00000362551.2, ENSP00000362551, Q38IA7, Q5VYE9, A0A0C4DFQ2_HUMAN, A0A0C4DFQ2, H2QXW8_PANTR, H2QXW8, G7NEQ0_MACMU, G7NEQ0, G8F587_MACFA, G8F587, H2PTF2_PONAB, H2PTF2, F7ITA7_CALJA, F7ITA7, A0A2I2ZRF2_GORGO, A0A2I2ZRF2, A0A2K6B2K2_MACNE, A0A2K6B2K2, A0A2K5KZ00_CERAT, A0A2K5KZ00, A0A2K6NH77_RHIRO, A0A2K6NH77, A0A096P214_PAPAN, A0A096P214, A0A2K5HFK2_COLAP, A0A2K5HFK2, A0A2K5XQF1_MANLE, A0A2K5XQF1, G1SBG4_NOMLE, G1SBG4, U3BVN1_CALJA, U3BVN1, F7GKW5_MACMU, F7GKW5, A0A2J8UKE8_PONAB, A0A2J8UKE8, A0A2J8NBV2_PANTR, A0A2J8NBV2
Source gene ENSG00000177125
Alternative splicing ENSP00000317534.4, ZBT34_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Coelomata

Predicted functional partners

ZBT34_HUMAN is shown as ZBTB34 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ZBTB34

Protein ZBT34_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05168Herpes simplex virus 1 infection

KEGG orthologous groups

KONameDescription
K09228KRABKRAB domain-containing zinc finger protein

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 2 PTMs annotated in this protein:

PTMCount
Phosphorylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ZBTB34.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000362551 in eggNOG.

OGTaxonomic classDescription
LKOG1721All organisms (root)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
KOG1721Eukaryota (superkingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
HT938Metazoa (kingdom)zinc finger and BTB domain-containing protein 37,zinc finger and BTB domain-containing protein 34,B-cell CLL/lymphoma 6 member B protein
93M03Chordata (phylum)zinc finger and BTB domain-containing protein 37,zinc finger and BTB domain-containing protein 34
5QYAPSarcopterygii (superclass)zinc finger and BTB domain-containing protein 37,zinc finger and BTB domain-containing protein 34
8YZCNMammalia (class)zinc finger and BTB domain-containing protein 34
4RSE3Euarchontoglires (superorder)zinc finger and BTB domain-containing protein 34
4ZPGFPrimates (order)zinc finger and BTB domain-containing protein 34
98JK7Haplorrhini (suborder)zinc finger and BTB domain-containing protein 34
BVG7YSimiiformes (infraorder)zinc finger and BTB domain-containing protein 34
9EKFFCatarrhini (parvorder)zinc finger and BTB domain-containing protein 34
7HPQ4Opisthokonta (clade)zinc finger and BTB domain-containing protein 37,zinc finger and BTB domain-containing protein 34,B-cell CLL/lymphoma 6 member B protein
H5VJ8Bilateria (clade)zinc finger and BTB domain-containing protein 37,zinc finger and BTB domain-containing protein 34,B-cell CLL/lymphoma 6 member B protein
9G993Vertebrata (clade)zinc finger and BTB domain-containing protein 37,zinc finger and BTB domain-containing protein 34
FX95PHominoidea (superfamily)zinc finger and BTB domain-containing protein 34
5N08AHominidae (family)zinc finger and BTB domain-containing protein 34
5XUVFHomininae (subfamily)zinc finger and BTB domain-containing protein 34

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: