Domains within Homo sapiens protein ZBT45_HUMAN (Q96K62)

Zinc finger and BTB domain-containing protein 45

Alternative representations: 1 /

Protein length511 aa
Source databaseUniProt
Identifiers ZBT45_HUMAN, Q96K62, ENSP00000346603.2, ENSP00000346603, ENSP00000469089.1, ENSP00000469089, ENSP00000473072.1, ENSP00000473072, A0A024R4T8_HUMAN, A0A024R4T8
Source gene ENSG00000119574
Alternative splicing ZBT45_HUMAN, ENSP00000470316.1, ENSP00000471885.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

ZBT45_HUMAN is shown as ZBTB45 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ZBTB45

Protein ZBT45_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05168Herpes simplex virus 1 infection

KEGG orthologous groups

KONameDescription
K09228KRABKRAB domain-containing zinc finger protein

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 4 PTMs annotated in this protein:

PTMCount
Phosphorylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein DKFZp547H249.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000346603 in eggNOG.

OGTaxonomic classDescription
LKOG1721All organisms (root)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
KOG1721Eukaryota (superkingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
HSV1IMetazoa (kingdom)zinc finger and BTB domain-containing protein 45
94PAHChordata (phylum)zinc finger and BTB domain-containing protein 45
5R2WNSarcopterygii (superclass)zinc finger and BTB domain-containing protein 45
8ZFEVMammalia (class)zinc finger and BTB domain-containing protein 45
4RA0ZEuarchontoglires (superorder)zinc finger and BTB domain-containing protein 45
503JTPrimates (order)zinc finger and BTB domain-containing protein 45
98FXWHaplorrhini (suborder)zinc finger and BTB domain-containing protein 45
BVHGDSimiiformes (infraorder)zinc finger and BTB domain-containing protein 45
9EWPHCatarrhini (parvorder)zinc finger and BTB domain-containing protein 45
H4IB1Bilateria (clade)zinc finger and BTB domain-containing protein 45
9FR1JVertebrata (clade)zinc finger and BTB domain-containing protein 45
7M405Opisthokonta (clade)zinc finger and BTB domain-containing protein 45
FX1KDHominoidea (superfamily)zinc finger and BTB domain-containing protein 45
5NCEIHominidae (family)zinc finger and BTB domain-containing protein 45
5Y3ETHomininae (subfamily)zinc finger and BTB domain-containing protein 45

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: