Domains within Homo sapiens protein FEZF1_HUMAN (A0PJY2)

Fez family zinc finger protein 1

Alternative representations: 1 /

Protein length475 aa
Source databaseUniProt
Identifiers FEZF1_HUMAN, A0PJY2, ENSP00000411145.2, ENSP00000411145, A0PJY3, A4D0W3, B4DUP9, B7ZM98
Source gene ENSG00000128610
Alternative splicing FEZF1_HUMAN, A0PJY2-2, C9J0C5_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

FEZF1_HUMAN is shown as FEZF1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for FEZF1

Protein FEZF1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05168Herpes simplex virus 1 infection

KEGG orthologous groups

KONameDescription
K09228KRABKRAB domain-containing zinc finger protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000411145 in eggNOG.

OGTaxonomic classDescription
LKOG1721All organisms (root)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
KOG1721Eukaryota (superkingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
HU1A6Metazoa (kingdom)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,IKAROS family zinc finger protein
94SZSChordata (phylum)Fez family zinc finger protein
5QNRESarcopterygii (superclass)Fez family zinc finger protein
8Z3M6Mammalia (class)Fez family zinc finger protein
4RIH1Euarchontoglires (superorder)Fez family zinc finger protein
4ZPD3Primates (order)Fez family zinc finger protein
98E7NHaplorrhini (suborder)Fez family zinc finger protein
BUYMXSimiiformes (infraorder)Fez family zinc finger protein
9EWW5Catarrhini (parvorder)Fez family zinc finger protein
9FQX2Vertebrata (clade)Fez family zinc finger protein
H663FBilateria (clade)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,IKAROS family zinc finger protein
7MTDYOpisthokonta (clade)KRAB domain-containing zinc finger protein,SCAN domain-containing zinc finger protein,KRAB and SCAN domains-containing zinc finger protein
FX389Hominoidea (superfamily)Fez family zinc finger protein
5N6JUHominidae (family)Fez family zinc finger protein
5XZG5Homininae (subfamily)Fez family zinc finger protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: