Domains within Homo sapiens protein FA12_HUMAN (P00748)
Coagulation factor XII
Alternative representations: 1 /
| Protein length | 615 aa |
|---|---|
| Source database | UniProt |
| Identifiers | FA12_HUMAN, P00748, ENSP00000253496.3, ENSP00000253496, P78339, Q96EF3_HUMAN, Q96EF3 |
| Source gene | ENSG00000131187 |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
This domain architecture was probably invented with the emergence of Eutheria
Predicted functional partners
FA12_HUMAN is shown as 
F12 in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein FA12_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map04974 | Protein digestion and absorption | |
| map04610 | Complement and coagulation cascades |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K01328 | F12 | coagulation factor XII (Hageman factor) [EC:3.4.21.38] | |
| K09631 | HGFAC | hepatocyte growth factor activator [EC:3.4.21.-] | |
| K00430 | E1.11.1.7 | peroxidase [EC:1.11.1.7] | iPath3 |
| K01312 | PRSS1_2_3 | trypsin [EC:3.4.21.4] |
Post-translational modifications
PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 24 PTMs annotated in this protein:
| PTM | Count | |
|---|---|---|
 | Phosphorylation | 7 |
 | O-linked glycosylation | 7 |
 | O-GalNAc glycosylation | 6 |
 | Proteolytic cleavage | 2 |
 | N-linked glycosylation | 2 |
To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein F12.
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000253496 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG5640 | All organisms (root) | trypsin [EC:3.4.21.4],chymotrypsin [EC:3.4.21.1],transmembrane protease serine 9 [EC:3.4.21.-] |
| 7553H | All organisms (root) | peroxidase [EC:1.11.1.7],transmembrane channel-like protein,thrombospondin 2/3/4/5 |
| KOG1217 | Eukaryota (superkingdom) | peroxidase [EC:1.11.1.7],transmembrane channel-like protein,thrombospondin 2/3/4/5 |
| KOG3627 | Eukaryota (superkingdom) | trypsin [EC:3.4.21.4],chymotrypsin [EC:3.4.21.1],transmembrane protease serine 9 [EC:3.4.21.-] |
| HW1HD | Metazoa (kingdom) | coagulation factor XII (Hageman factor) [EC:3.4.21.38],hepatocyte growth factor activator [EC:3.4.21.-],hyaluronan binding protein 2 [EC:3.4.21.-] |
| 93KU7 | Chordata (phylum) | coagulation factor XII (Hageman factor) [EC:3.4.21.38],hepatocyte growth factor activator [EC:3.4.21.-] |
| 5QF0A | Sarcopterygii (superclass) | coagulation factor XII (Hageman factor) [EC:3.4.21.38],hepatocyte growth factor activator [EC:3.4.21.-] |
| 8ZIXZ | Mammalia (class) | coagulation factor XII (Hageman factor) [EC:3.4.21.38],hepatocyte growth factor activator [EC:3.4.21.-] |
| 4RHGR | Euarchontoglires (superorder) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
| 4ZN12 | Primates (order) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
| 98HMV | Haplorrhini (suborder) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
| BVIUA | Simiiformes (infraorder) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
| 9ERNI | Catarrhini (parvorder) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
| 9FU73 | Vertebrata (clade) | coagulation factor XII (Hageman factor) [EC:3.4.21.38],hepatocyte growth factor activator [EC:3.4.21.-] |
| H5XM3 | Bilateria (clade) | coagulation factor XII (Hageman factor) [EC:3.4.21.38],hepatocyte growth factor activator [EC:3.4.21.-],hyaluronan binding protein 2 [EC:3.4.21.-] |
| 7GFAW | Opisthokonta (clade) | coagulation factor XII (Hageman factor) [EC:3.4.21.38],hepatocyte growth factor activator [EC:3.4.21.-],hyaluronan binding protein 2 [EC:3.4.21.-] |
| FX53V | Hominoidea (superfamily) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
| 5N81Y | Hominidae (family) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
| 5XXR1 | Homininae (subfamily) | coagulation factor XII (Hageman factor) [EC:3.4.21.38] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.