Domains within Homo sapiens protein TPR_HUMAN (P12270)
Nucleoprotein TPR
Alternative representations: 1 /
| Protein length | 2363 aa |
|---|---|
| Source database | UniProt |
| Identifiers | TPR_HUMAN, P12270, ENSP00000356448.3, ENSP00000356448, Q15624, Q5SWY0, Q99968 |
| Source gene | ENSG00000047410 |
| Alternative splicing | TPR_HUMAN, ENSP00000408103.1, P12270-2 |
Predicted functional partners
TPR_HUMAN is shown as 
TPR in the network
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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Post-translational modifications
PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 144 PTMs annotated in this protein:
| PTM | Count | |
|---|---|---|
 | Phosphorylation | 78 |
 | Ubiquitination | 37 |
 | Acetylation | 21 |
 | Methylation | 5 |
 | O-linked glycosylation | 1 |
 | Caspase cleavage aspartic acid | 1 |
 | O-GlcNAc glycosylation | 1 |
To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein TPR.
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000356448 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LKOG4674 | All organisms (root) | nucleoprotein TPR,pectate lyase [EC:4.2.2.2],golgin subfamily B member 1 |
| KOG4674 | Eukaryota (superkingdom) | nucleoprotein TPR,pectate lyase [EC:4.2.2.2],golgin subfamily B member 1 |
| HUSBA | Metazoa (kingdom) | nucleoprotein TPR,golgin subfamily B member 1 |
| 93V4F | Chordata (phylum) | nucleoprotein TPR |
| 5R7A2 | Sarcopterygii (superclass) | nucleoprotein TPR |
| 8ZCAN | Mammalia (class) | nucleoprotein TPR |
| 4RKUU | Euarchontoglires (superorder) | nucleoprotein TPR |
| 4ZWCQ | Primates (order) | nucleoprotein TPR |
| 98AVV | Haplorrhini (suborder) | nucleoprotein TPR |
| BV2AV | Simiiformes (infraorder) | nucleoprotein TPR |
| 9EX9R | Catarrhini (parvorder) | nucleoprotein TPR |
| H3XSQ | Bilateria (clade) | nucleoprotein TPR,golgin subfamily B member 1 |
| 7K2E3 | Opisthokonta (clade) | nucleoprotein TPR,golgin subfamily B member 1,EKC/KEOPS complex subunit LAGE3/PCC1 |
| 9FQV0 | Vertebrata (clade) | nucleoprotein TPR |
| FX8YE | Hominoidea (superfamily) | nucleoprotein TPR |
| 5N239 | Hominidae (family) | nucleoprotein TPR |
| 5XS0V | Homininae (subfamily) | nucleoprotein TPR |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.