Domains within Homo sapiens protein PSG5_HUMAN (Q15238)

Pregnancy-specific beta-1-glycoprotein 5

Alternative representations: 1 /

Protein length335 aa
Source databaseUniProt
Identifiers Q15238, PSG5_HUMAN, ENSP00000382334.2, ENSP00000382334, ENSP00000386008.1, ENSP00000386008, ENSP00000344413.6, ENSP00000344413, Q15239, Q96QJ1, Q9UQ75, A0A024R0S1_HUMAN, A0A024R0S1
Source gene ENSG00000204941
Alternative splicing PSG5_HUMAN, E9PC55_HUMAN, M0R1G9_HUMAN, E7EQY3_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

PSG5_HUMAN is shown as PSG5 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for PSG5

Protein PSG5_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05169Epstein-Barr virus infection
map04722Neurotrophin signaling pathway
map05166Human T-cell leukemia virus 1 infection
map04625C-type lectin receptor signaling pathway

KEGG orthologous groups

KONameDescription
K10999CESAcellulose synthase A [EC:2.4.1.12]
K06867K06867uncharacterized protein
K06499CEACAM, CD66carcinoembryonic antigen-related cell adhesion molecule

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 4 PTMs annotated in this protein:

PTMCount
Phosphorylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein PSG.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000382334 in eggNOG.

OGTaxonomic classDescription
LCOG0666All organisms (root)uncharacterized protein,Mce-associated membrane protein,cellulose synthase A [EC:2.4.1.12]
KOG0504Eukaryota (superkingdom)cellulose synthase A [EC:2.4.1.12],beta-mannan synthase [EC:2.4.1.32],uncharacterized protein
HUPK9Metazoa (kingdom)carcinoembryonic antigen-related cell adhesion molecule,NF-kappa-B inhibitor alpha,nuclear factor NF-kappa-B p105 subunit
9407NChordata (phylum)B-cell CLL/lymphoma 3 protein,carcinoembryonic antigen-related cell adhesion molecule,pregnancy specific beta-1-glycoprotein
9G4Q9Vertebrata (clade)B-cell CLL/lymphoma 3 protein,carcinoembryonic antigen-related cell adhesion molecule,pregnancy specific beta-1-glycoprotein
7MMYUOpisthokonta (clade)carcinoembryonic antigen-related cell adhesion molecule,ankyrin repeat domain-containing protein 50,NF-kappa-B inhibitor alpha
H58U6Bilateria (clade)carcinoembryonic antigen-related cell adhesion molecule,NF-kappa-B inhibitor alpha,ankyrin repeat domain-containing protein 6

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: