Domains within Homo sapiens protein NBEL1_HUMAN (Q6ZS30)

Neurobeachin-like protein 1

Alternative representations: 1 /

Protein length2694 aa
Source databaseUniProt
Identifiers NBEL1_HUMAN, Q6ZS30, ENSP00000399903.1, ENSP00000399903, A6NHD5, Q6Y876, Q6ZP36, Q6ZQY5, Q8N8R4, Q96Q30, Q96Q31
Source gene ENSG00000144426
Alternative splicing NBEL1_HUMAN, H7BZA0_HUMAN, H7C3C8_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

NBEL1_HUMAN is shown as NBEAL1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for NBEAL1

Protein NBEL1_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04071Sphingolipid signaling pathway

KEGG orthologous groups

KONameDescription
K23286NEBL1_2neurobeachin-like protein 1/2

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 16 PTMs annotated in this protein:

PTMCount
Phosphorylation12
Ubiquitination4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ALS2CR16.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000399903 in eggNOG.

OGTaxonomic classDescription
LKOG1787All organisms (root)neurobeachin-like protein 1/2,neurobeachin,lipopolysaccharide-responsive and beige-like anchor protein
KOG1787Eukaryota (superkingdom)neurobeachin-like protein 1/2,neurobeachin,lipopolysaccharide-responsive and beige-like anchor protein
HUMY6Metazoa (kingdom)neurobeachin-like protein 1/2,factor associated with neutral sphingomyelinase activation
93TUFChordata (phylum)neurobeachin-like protein 1/2
5QDFFSarcopterygii (superclass)neurobeachin-like protein 1/2
8YVF3Mammalia (class)neurobeachin-like protein 1/2
4R1TJEuarchontoglires (superorder)neurobeachin-like protein 1/2
4ZXQ6Primates (order)neurobeachin-like protein 1/2
98Q6THaplorrhini (suborder)neurobeachin-like protein 1/2
BV06GSimiiformes (infraorder)neurobeachin-like protein 1/2
9EGUMCatarrhini (parvorder)neurobeachin-like protein 1/2
7IXXCOpisthokonta (clade)neurobeachin-like protein 1/2,neurobeachin,lipopolysaccharide-responsive and beige-like anchor protein
9G1XEVertebrata (clade)neurobeachin-like protein 1/2
H4PDXBilateria (clade)neurobeachin-like protein 1/2
FX664Hominoidea (superfamily)neurobeachin-like protein 1/2
5MZATHominidae (family)neurobeachin-like protein 1/2
5XZZ6Homininae (subfamily)neurobeachin-like protein 1/2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: