Domains within Saccharomyces cerevisiae protein YDR177W

Alternative representations: 1 /

Protein length215 aa
Source databaseEnsembl
Identifiers YDR177W
Source gene YDR177W

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

YDR177W is shown as UBC1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for UBC1

Protein YDR177W is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04120Ubiquitin mediated proteolysis

KEGG orthologous groups

KONameDescription
K06689UBE2D, UBC4, UBC5ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
K04649UBE2K, HIP2, UBC1ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 4932.YDR177W in eggNOG.

OGTaxonomic classDescription
LCOG5078All organisms (root)ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23],ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24],ubiquitin-conjugating enzyme E2 I
FSM2RDikarya (subkingdom)ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
KOG0418Eukaryota (superkingdom)ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23],E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27],ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
BKC05Fungi (kingdom)ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
9SN25Ascomycota (phylum)ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
91II0Saccharomycetales (order)ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
7GBZWOpisthokonta (clade)ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23],E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27]
AT7NASaccharomycetaceae (family)ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: