Domains within Saccharomyces cerevisiae protein YDR448W

Alternative representations: 1 /

Protein length434 aa
Source databaseEnsembl
Identifiers YDR448W
Source gene YDR448W

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

YDR448W is shown as ADA2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ADA2

Protein YDR448W is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03020RNA polymerase

KEGG orthologous groups

KONameDescription
K11314TADA2A, ADA2transcriptional adapter 2-alpha

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 2 PTMs annotated in this protein:

PTMCount
Phosphorylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ADA2.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 4932.YDR448W in eggNOG.

OGTaxonomic classDescription
FRZ3EDikarya (subkingdom)transcriptional adapter 2-alpha
LKOG0457All organisms (root)transcriptional adapter 2-beta,transcriptional adapter 2-alpha,DNA-directed RNA polymerase II subunit RPB4
KOG0457Eukaryota (superkingdom)transcriptional adapter 2-beta,transcriptional adapter 2-alpha,DNA-directed RNA polymerase II subunit RPB4
BM56NFungi (kingdom)transcriptional adapter 2-alpha
9SZHIAscomycota (phylum)transcriptional adapter 2-alpha
91EDYSaccharomycetales (order)transcriptional adapter 2-alpha
7GEYHOpisthokonta (clade)transcriptional adapter 2-alpha
AT50DSaccharomycetaceae (family)transcriptional adapter 2-alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: