Domains within Saccharomyces cerevisiae protein YLR452C

Alternative representations: 1 /

Protein length698 aa
Source databaseEnsembl
Identifiers YLR452C
Source gene YLR452C

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi

Predicted functional partners

YLR452C is shown as SST2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for SST2

Protein YLR452C is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04921Oxytocin signaling pathway
map04011MAPK signaling pathway - yeast
map05225Hepatocellular carcinoma

KEGG orthologous groups

KONameDescription
K19838SST2GTPase-activating protein SST2
K16449RGSregulator of G-protein signaling

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 9 PTMs annotated in this protein:

PTMCount
Phosphorylation9

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein AWRI1631_124800.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 4932.YLR452C in eggNOG.

OGTaxonomic classDescription
FRKHEDikarya (subkingdom)GTPase-activating protein SST2
LKOG3589All organisms (root)regulator of G-protein signaling,axin 1,regulator of G-protein signaling 2
KOG3589Eukaryota (superkingdom)regulator of G-protein signaling,axin 1,regulator of G-protein signaling 2
BNPGMFungi (kingdom)GTPase-activating protein SST2
9T31CAscomycota (phylum)GTPase-activating protein SST2
91M2RSaccharomycetales (order)GTPase-activating protein SST2
7GRC5Opisthokonta (clade)regulator of G-protein signaling,regulator of G-protein signaling 2,regulator of G-protein signaling 9
AT92QSaccharomycetaceae (family)GTPase-activating protein SST2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: