Domains within Homo sapiens protein ZAP70_HUMAN (P43403)
Tyrosine-protein kinase ZAP-70
Alternative representations: 1 /
| Protein length | 619 aa |
|---|---|
| Source database | UniProt |
| Identifiers | ZAP70_HUMAN, P43403, ENSP00000264972.5, ENSP00000264972, A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6 |
| Source gene | ENSG00000115085 |
| Alternative splicing | ZAP70_HUMAN, ENSP00000400475.2 |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
This domain architecture was probably invented with the emergence of Metazoa
Predicted functional partners
ZAP70_HUMAN is shown as 
ZAP70 in the network
Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.
The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein ZAP70_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map04360 | Axon guidance | |
| map04621 | NOD-like receptor signaling pathway | |
| map04650 | Natural killer cell mediated cytotoxicity |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K23698 | SLA | src-like-adapter | |
| K04427 | MAP3K7, TAK1 | mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25] | |
| K08852 | ERN1 | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-] | |
| K05855 | SYK | spleen tyrosine kinase [EC:2.7.10.2] | |
| K07360 | ZAP70 | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
Post-translational modifications
PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 65 PTMs annotated in this protein:
| PTM | Count | |
|---|---|---|
 | Phosphorylation | 42 |
 | Ubiquitination | 18 |
 | Acetylation | 5 |
To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ZAP70.
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000264972 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0478 | All organisms (root) | serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-],RAC serine/threonine-protein kinase [EC:2.7.11.1],pto-interacting protein 1 [EC:2.7.11.1] |
| KOG0192 | Eukaryota (superkingdom) | src-like-adapter,sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25],ubiquinol oxidase [EC:1.10.3.11] |
| HVZ81 | Metazoa (kingdom) | spleen tyrosine kinase [EC:2.7.10.2],tyrosine-protein kinase ZAP-70 [EC:2.7.10.2],tyrosine-protein kinase shark [EC:2.7.10.2] |
| 93SKZ | Chordata (phylum) | spleen tyrosine kinase [EC:2.7.10.2],tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 5QV2R | Sarcopterygii (superclass) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 8YV8N | Mammalia (class) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 4RM9U | Euarchontoglires (superorder) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 503SN | Primates (order) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 98MRW | Haplorrhini (suborder) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| BVFPI | Simiiformes (infraorder) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 9EHGT | Catarrhini (parvorder) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 7I1FF | Opisthokonta (clade) | mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25],mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25],sterile alpha motif and leucine zipper containing kinase AZK [EC:2.7.11.25] |
| H4D6R | Bilateria (clade) | spleen tyrosine kinase [EC:2.7.10.2],tyrosine-protein kinase ZAP-70 [EC:2.7.10.2],tyrosine-protein kinase shark [EC:2.7.10.2] |
| 9GBKT | Vertebrata (clade) | spleen tyrosine kinase [EC:2.7.10.2],tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| FX7JK | Hominoidea (superfamily) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 5N399 | Hominidae (family) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
| 5Y45Y | Homininae (subfamily) | tyrosine-protein kinase ZAP-70 [EC:2.7.10.2] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.