This entry represents the N-terminal domain found in several lipid-binding serum glycoproteins. The N- and C-terminal domains share a similar two-layer α/β structure, but they show little sequence identity. Proteins containing this N-terminal domain include:

• Bactericidal permeability-increasing protein (BPI)
• Lipopolysaccharide-binding protein (LBP)
• Cholesteryl … expand

This entry represents the N-terminal domain found in several lipid-binding serum glycoproteins. The N- and C-terminal domains share a similar two-layer α/β structure, but they show little sequence identity. Proteins containing this N-terminal domain include:

• Bactericidal permeability-increasing protein (BPI)
• Lipopolysaccharide-binding protein (LBP)
• Cholesteryl ester transfer protein (CETP)
• Phospholipid transfer protein (PLTP)
• Palate, lung and nasal epithelium carcinoma-associated protein (PLUNC)

Bactericidal permeability-increasing protein (BPI) is a potent antimicrobial protein of 456 residues that binds to and neutralises lipopolysaccharides from the outer membrane of Gram-negative bacteria [ PUBMED:9188532 ]. BPI contains two domains that adopt the same structural fold, even though they have little sequence similarity [ PUBMED:10843855 ].