 CTC-terminal cystine knot-like domain (CTCK) | |
|---|---|
| SMART ACC: | SM000041 |
| Description: | The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers. |
| InterPro ACC: | IPR006207 |
| InterPro abstract: | Four recent crystal structures of growth factors--nerve growth factor, transforming growth factor-beta, platelet-derived growth factor, and human chorionic gonadotropin--from four separate superfamilies revealed that these proteins are structurally related and share a common overall topology [ PUBMED:8490958 ]. These … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 7 744 CT domains in 7 736 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing CT domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing CT domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Relevant references for this domain
Primary literature for the CT domain is listed below. Automatically-derived, secondary literature is also available.
Disease genes where sequence variants are found in this domain
UniRef sequences and OMIM curated human diseases associated with missense mutations within the CT domain.
| Protein | Description | Disease / phenotype |
|---|---|---|
| NDP_HUMAN | OMIM:310600 : Norrie disease ; Exudative vitreoretinopathy, X-linked | |
| OMIM:305390 : Coats disease | ||
| OMIM:300216 : no description | ||
| VWF_HUMAN | OMIM:193400 : von Willebrand disease |
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a CT domain which could be assigned to a KEGG orthologous group, and not all proteins containing CT domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.