Glycosyl hydrolase family 10
SMART accession number:SM00633
Description: -
Interpro abstract (IPR001000):

O-Glycosyl hydrolases ( EC 3.2.1. ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ (PUBMED:7624375) (PUBMED:8535779) ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Glycoside hydrolase family 10 comprises enzymes with a number of known activities; xylanase ( EC ); endo-1,3-beta-xylanase ( EC ); cellobiohydrolase ( EC ). These enzymes were formerly known as cellulase family F.

The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases ( EC ), cellobiohydrolases ( EC ) (exoglucanases), or xylanases ( EC ) [ (PUBMED:2252383) (PUBMED:1886523) ]. Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family F [ (PUBMED:2806912) ] or as the glycosyl hydrolases family 10 [ (PUBMED:1747104) ].

The overall structure of the GH10 domain corresponds to an eightfold alpha/beta-barrel (TIM-barrel) with a typical deep groove in the centre, allowing an 'endo' type of action on the large polysaccharide backbone [ (PUBMED:17642511) ], [ (PUBMED:23508990) ].

GO process:carbohydrate metabolic process (GO:0005975)
GO function:hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)
Family alignment:
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There are 11067 Glyco_10 domains in 11041 proteins in SMART's nrdb database.

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