The domain within your query sequence starts at position 404 and ends at position 595; the E-value for the ALBUMIN domain shown below is 1.51e-83.

LVEEPKNLVKTNCDLYEKLGEYGFQNAILVRYTQKAPQVSTPTLVEAARNLGRVGTKCCT
LPEDQRLPCVEDYLSAILNRVCLLHEKTPVSEHVTKCCSGSLVERRPCFSALTVDETYVP
KEFKAETFTFHSDICTLPEKEKQIKKQTALAELVKHKPKATAEQLKTVMDDFAQFLDTCC
KAADKDTCFSTE

ALBUMIN

serum albumin

• SMART accession number: SM00103
• Description: -
• Interpro abstract (IPR014760):

  A number of serum transport proteins are known to be evolutionarily related, including albumin, alpha-fetoprotein, vitamin D-binding protein and afamin [ (PUBMED:2481749) (PUBMED:2423133) (PUBMED:7517938) ]. Albumin is the main protein of plasma; it binds water, cations (such as Ca ²⁺ Na ⁺ and K ⁺ ), fatty acids, hormones, bilirubin and drugs - its main function is to regulate the colloidal osmotic pressure of blood. Alphafeto- protein (alpha-fetoglobulin) is a foetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin D-binding protein binds to vitamin D and its metabolites, as well as to fatty acids. The biological role of afamin (alpha-albumin) has not yet been characterised. The 3D structure of human serum albumin has been determined by X-ray crystallography to a resolution of 2.8A [ (PUBMED:1630489) ]. It comprises three homologous domains that assemble to form a heart-shaped molecule [ (PUBMED:1630489) ]. Each domain is a product of two subdomains that possess common structural motifs [ (PUBMED:1630489) ]. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. Structurally, the serum albumins are similar, each domain containing five or six internal disulphide bonds, as shown schematically below:

                      +---+          +----+                        +-----+
                      |   |          |    |                        |     |
   xxCxxxxxxxxxxxxxxxxCCxxCxxxxCxxxxxCCxxxCxxxxxxxxxCxxxxxxxxxxxxxxCCxxxxCxxxx
     |                 |       |     |              |               |
     +-----------------+       +-----+              +---------------+
  

• GO component: extracellular space (GO:0005615)

There are 2862 ALBUMIN domains in 1132 proteins in SMART's nrdb database.

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Carter DC, Ho JX
• Structure of serum albumin.
• Adv Protein Chem. 1994; 45: 153-203

• Gray JE, Doolittle RF
• Characterization, primary structure, and evolution of lamprey plasma albumin.
• Protein Sci. 1992; 1: 289-302

The most abundant protein found in blood plasma from the sea lamprey (Petromyzon marinus) has the hallmarks of a plasma albumin: namely, high abundance, solubility in distilled water, a small number of tryptophans, and a high content of cysteines and charged residues. As in other vertebrate albumins, not all the cysteines are disulfide bonded. An unusual feature of this protein is its molecular weight of 175,000, roughly 2.5 times the size of other vertebrate albumins. Its amino acid sequence, deduced from a series of overlapping cDNA clones, can be aligned with other members of the gene family including plasma albumin, alpha-fetoprotein, and vitamin-D binding protein, confirming that it is indeed an oversized albumin. An unusual feature of the sequence is a 28-amino acid stretch consisting of a serine-threonine repeat with the general motif (STTT). Lamprey albumin contains a 23-amino acid putative signal peptide and a 6-residue putative propeptide, which, when cleaved, yield a mature protein of 1,394 amino acids with a calculated molecular weight of 157,000. The sequence also includes nine potential N-linked glycosylation sites (Asn-X-Ser/Thr), consistent with observation that lamprey albumin is a glycoprotein. If all the potential glycosylation sites were occupied by clusters of 2,000 molecular weight each, the total molecular weight would be 175,000. Like other members of the gene family, lamprey albumin is composed of a series of 190-amino acid repeats, there being seven such domains all together. Quantitative amino acid sequence comparisons of lamprey albumin with the other members of the gene family indicate that it diverged from an ancestral albumin prior to the gene duplications leading to this diverse group. This notion is confirmed by the pattern of amino acid insertions and deletions observed in a consideration of all domains that compose this family. Furthermore, it suggests that the invention of albumin antedates the vertebrate radiation.

• Alexander F, Young PR, Tilghman SM
• Evolution of the albumin: alpha-fetoprotein ancestral gene from the amplification of a 27 nucleotide sequence.
• J Mol Biol. 1984; 173: 159-73

The genes for alpha-fetoprotein and albumin arose by duplication of an ancestral gene that contained three genetic domains. These domains were generated by the triplication of a primordial genetic domain composed of five exons or subdomains. That the primordial domain itself arose by amplification of a simpler sequence is suggested by nucleotide sequence homologies among the subdomains of the mouse alpha-fetoprotein gene. A detailed analysis of these homologies reveals that each of the five subdomain families contains remnants of a 27-base-long repeat from which the entire alpha-fetoprotein coding sequence has been assembled. A consensus sequence for the 27 nucleotide repeat is derived, and the positions of the repeats within each subdomain are described. A model is proposed for the evolution of the primordial domain by the amplification and divergence of the 27 base-pair sequence, along with the condensation of the repeats into subdomains separated by intervening sequences. It is postulated that the role of intervening sequences may be to limit sequence amplification in genes such as alpha-fetoprotein and albumin whose protein products cannot tolerate size variation.

• Eiferman FA, Young PR, Scott RW, Tilghman SM
• Intragenic amplification and divergence in the mouse alpha-fetoprotein gene.
• Nature. 1981; 294: 713-8

The DNA sequences of the 14 exon junctions in the murine alpha-fetoprotein gene were determined using cloned genomic DNA. When these exons were examined with respect to the polypeptide segments they encoded, a direct correspondence between a threefold repeat of four exons and three protein domains was observed. Nucleotide sequence comparisons among the four exons of each domain were used to deduce the likely structure of the primordial domain, and the order and mechanism of its triplication to form the tripartite ancestral gene from which both alpha-fetoprotein and serum albumin arose. Sequence homologies among the four exons that constitute a single domain also suggest that they were derived, at least in part, from a common sequence which underwent successive amplification and divergence.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the ALBUMIN domain.

Protein	Disease
Serum albumin (P02768) (SMART)	OMIM:103600: Analbuminemia ; [Dysalbuminemic hyperthyroxinemia] ; [Dysalbuminemic hyperzincemia] OMIM:194470:

Structure (3D structures containing this domain)

3D Structures of ALBUMIN domains in PDB

PDB code	Title
1ao6	CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN
1bj5	HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID
1bke	HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID
1bm0	CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN
1e78	Crystal structure of human serum albumin
1e7a	Crystal structure of human serum albumin complexed with the general anesthetic propofol
1e7b	Crystal structure of human serum albumin complexed with the general anesthetic halothane
1e7c	HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID and the general anesthetic halothane
1e7e	HUMAN SERUM ALBUMIN COMPLEXED WITH DECANOIC ACID (CAPRIC ACID)
1e7f	HUMAN SERUM ALBUMIN COMPLEXED WITH DODECANOIC ACID (LAURIC ACID)
1e7g	Human serum albumin complexed with tetradecanoic acid (myristic acid)
1e7h	HUMAN SERUM ALBUMIN COMPLEXED WITH HEXADECANOIC ACID (PALMITIC ACID)
1e7i	HUMAN SERUM ALBUMIN COMPLEXED WITH OCTADECANOIC ACID (STEARIC ACID)
1gni	HUMAN SERUM ALBUMIN COMPLEXED WITH cis-9-OCTADECENOIC ACID (OLEIC ACID)
1gnj	HUMAN SERUM ALBUMIN COMPLEXED WITH cis-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)
1h9z	Human Serum Albumin Complexed With Myristic Acid and the R-(+) enantiomer of warfarin
1ha2	Human Serum Albumin Complexed With Myristic Acid and the S-(-) enantiomer of warfarin
1hk1	HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE)
1hk2	HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE)
1hk3	Human serum albumin mutant r218p complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
1hk4	HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid)
1hk5	HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid)
1j78	Crystallographic analysis of the human vitamin D binding protein
1j7e	A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein
1kw2	CRYSTAL STRUCTURE OF UNCOMPLEXED VITAMIN D-BINDING PROTEIN
1kxp	CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN
1lot	CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN
1ma9	Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin
1n5u	X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEME
1o9x	HUMAN SERUM ALBUMIN COMPLEXED WITH TETRADECANOIC ACID (MYRISTIC ACID) AND HEMIN
1tf0	Crystal structure of the GA module complexed with human serum albumin
1uor	X-RAY STUDY OF RECOMBINANT HUMAN SERUM ALBUMIN. PHASES DETERMINED BY MOLECULAR REPLACEMENT METHOD, USING LOW RESOLUTION STRUCTURE MODEL OF TETRAGONAL FORM OF HUMAN SERUM ALBUMIN
1ysx	Solution structure of domain 3 from human serum albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2
2bx8	Human serum albumin complexed with azapropazone
2bxa	Human serum albumin complexed with 3-carboxy-4-methyl-5-propyl-2- furanpropanoic acid (CMPF)
2bxb	Human serum albumin complexed with oxyphenbutazone
2bxc	Human serum albumin complexed with phenylbutazone
2bxd	Human serum albumin complexed with warfarin
2bxe	Human serum albumin complexed with diflunisal
2bxf	Human serum albumin complexed with diazepam
2bxg	Human serum albumin complexed with ibuprofen
2bxh	Human serum albumin complexed with indoxyl sulfate
2bxi	Human serum albumin complexed with myristate and azapropazone
2bxk	Human serum albumin complexed with myristate, azapropazone and indomethacin
2bxl	Human serum albumin complexed with myristate and 3,5-diiodosalicylic acid
2bxm	Human serum albumin complexed with myristate and indomethacin
2bxn	Human serum albumin complexed with myristate and iodipamide
2bxo	Human serum albumin complexed with myristate and oxyphenbutazone
2bxp	Human serum albumin complexed with myristate and phenylbutazone
2bxq	Human serum albumin complexed with myristate, phenylbutazone and indomethacin
2esg	Solution structure of the complex between immunoglobulin IgA1 and human serum albumin
2i2z	Human serum albumin complexed with myristate and aspirin
2i30	Human serum albumin complexed with myristate and salicylic acid
2vdb	Structure of human serum albumin with S-naproxen and the GA module
2vue	Human serum albumin complexed with 4Z,15E-bilirubin-IX-alpha
2vuf	Human serum albumin complexed with fusidic acid
2xsi	Human serum albumin complexed with dansyl-L-glutamate and myristic acid
2xvq	Human serum albumin complexed with dansyl-L-sarcosine
2xvu	Human serum albumin complexed with dansyl-L-asparagine
2xvv	Human serum albumin complexed with dansyl-L-asparagine and myristic acid
2xvw	Human serum albumin complexed with dansyl-L-arginine and myristic acid
2xw0	Human serum albumin complexed with dansyl-L-phenylalanine
2xw1	Human serum albumin complexed with dansyl-L-norvaline
2ydf	HUMAN SERUM ALBUMIN COMPLEXED WITH IOPHENOXIC ACID
3a73	Crystal Structure Analysis of Human serum albumin complexed with delta 12-prostaglandin J2
3b9l	Human serum albumin complexed with myristate and AZT
3b9m	Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid
3cx9	Crystal Structure of Human serum albumin complexed with Myristic acid and lysophosphatidylethanolamine
3jqz	Crystal Structure of Human serum albumin complexed with Lidocaine
3jry	Human Serum albumin with bound Sulfate
3lu6	Human serum albumin in complex with compound 1
3lu7	Human serum albumin in complex with compound 2
3lu8	Human serum albumin in complex with compound 3
3sqj	Recombinant human serum albumin from transgenic plant
3tdl	Structure of human serum albumin in complex with DAUDA
3uiv	Human serum albumin-myristate-amantadine hydrochloride complex
3v03	Crystal structure of Bovine Serum Albumin
3v08	Crystal structure of Equine Serum Albumin
3v09	Crystal structure of Rabbit Serum Albumin
4bke	Recombinant human serum albumin with palmitic acid. Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin
4e99	Human Serum Albumin Complex with Perfluorooctane Sulfonate Potassium
4emx	Crystal structure analysis of Human Serum Albumin in complex with chloride anions at cryogenic temperature
4f5s	Crystal Structure of Bovine Serum Albumin
4f5t	Crystal Structure of Equine Serum Albumin
4f5u	Crystal structure of Equine Serum Albumin at 2.04 resolution
4f5v	Crystal Structure of Leporine Serum Albumin
4g03	High-resolution Crystal Structural Variance Analysis between Recombinant and Wild-type Human Serum Albumin
4g04	High-resolution Crystal Structural Variance Analysis between Recombinant and Wild-type Human Serum Albumin
4hgk	Shark IgNAR variable domain
4hgm	Shark IgNAR Variable Domain
4iw1	HSA-fructose complex
4iw2	HSA-glucose complex
4j2v	Crystal Structure of Equine Serum Albumin in complex with 3,5-diiodosalicylic acid
4jk4	Crystal Structure of Bovine Serum Albumin in complex with 3,5-diiodosalicylic acid
4k2c	HSA Ligand Free
4k71	Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor
4l8u	X-ray study of human serum albumin complexed with 9 amino camptothecin
4l9k	X-ray study of human serum albumin complexed with camptothecin
4l9q	X-ray study of human serum albumin complexed with teniposide
4la0	X-ray study of human serum albumin complexed with bicalutamide
4lb2	X-ray study of human serum albumin complexed with idarubicin
4lb9	X-ray study of human serum albumin complexed with etoposide
4luf	4LUF
4luh	4LUH
4n0f	Human FcRn complexed with human serum albumin
4n0u	Ternary complex between Neonatal Fc receptor, serum albumin and Fc
4or0	4OR0
4ot2	4OT2
4po0	4PO0
4s1y	4S1Y
4z69	4Z69
4zbq	4ZBQ
4zbr	4ZBR
5dby	5DBY
5dqf	5DQF
5fuo	5FUO
5ghk	5GHK
5hoz	5HOZ
5id7	5ID7
5id9	5ID9
5ifo	5IFO
5iih	5IIH
5iiu	5IIU
5iix	5IIX
5ij5	5IJ5
5ije	5IJE
5ijf	5IJF

Links (links to other resources describing this domain)

• PROSITE: PS00212
• INTERPRO: IPR014760