The domain within your query sequence starts at position 1330 and ends at position 1384; the E-value for the HECTc domain shown below is 7e-8.

Some of the required catalytic sites were not detected in this domain. It is probably inactive! Check the literature (PubMed 22423789 ) for details.

Catalytic residues
PositionAmino acidPresent?

The domain was found using the schnipsel database


Domain Homologous to E6-AP Carboxyl Terminus with
SMART accession number:SM00119
Description: E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Interpro abstract (IPR000569):

The HECT (Homologous to the E6-AP Carboxyl Terminus) domain is an around 350 amino acids motif that has been identified in proteins that all belong to a particular E3 ubiquitin-protein ligase family [ (PUBMED:7708685) ]. HECT domain containing proteins accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then transfer it to lysine side chains of target proteins, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. The site of ubiquitin thioester formation is a conserved cysteine residue located in the last 32-36 aa of the HECT domain [ (PUBMED:7708685) ]. The amino-terminal part of the HECT domain has been involved in E2 binding [ (PUBMED:9182527) (PUBMED:9153201) ]. Once linked to ubiquitin, the target proteins are degraded in the 26 S proteasome.

GO function:ubiquitin-protein transferase activity (GO:0004842)
Family alignment:
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There are 23694 HECTc domains in 23671 proteins in SMART's nrdb database.

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