The domain within your query sequence starts at position 333 and ends at position 381; the E-value for the CBS domain shown below is 8.69e-11.
DLAVVLETAPVLTALDIFVDRRVSALPVVNESGQVVGLYSRFDVIHLAA
CBSDomain in cystathionine beta-synthase and other proteins. |
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SMART accession number: | SM00116 |
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Description: | Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure [3]. A number of disease states are associated with CBS-containing proteins including homocystinuria, Becker's and Thomsen disease. |
Interpro abstract (IPR000644): | CBS domains are small intracellular modules that pair together to form a stable globular domain [ (PUBMED:10200156) ]. Pairs of these domains have been termed a Bateman domain [ (PUBMED:14722609) ]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [ (PUBMED:14722619) ]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in cystathionine-beta synthase is involved in regulation by S-AdoMet [ (PUBMED:11524006) ]. CBS domain pairs from AMPK bind AMP or ATP [ (PUBMED:14722619) ]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [ (PUBMED:14722619) ]. |
Family alignment: |
There are 371514 CBS domains in 203268 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing CBS domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CBS domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing CBS domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
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Binding / catalysis: unknown
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Bateman A
- The structure of a domain common to archaebacteria and the homocystinuria disease protein.
- Trends Biochem Sci. 1997; 22: 12-3
- Ponting CP
- CBS domains in CIC chloride channels implicated in myotonia and nephrolithiasis (kidney stones).
- J Mol Med. 1997; 75: 160-3
- Sintchak MD et al.
- Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
- Cell. 1996; 85: 921-30
- Display abstract
The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.
- Disease (disease genes where sequence variants are found in this domain)
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SwissProt sequences and OMIM curated human diseases associated with missense mutations within the CBS domain.
Protein Disease UNKNOWN (SMART) OMIM:236200: Homocystinuria, B6-responsive and nonresponsive types - Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 38.46 map00230 Purine metabolism 11.88 map02010 ABC transporters - General 5.94 map00450 Selenoamino acid metabolism 5.74 map00271 Methionine metabolism 4.87 map00260 Glycine, serine and threonine metabolism 4.87 map05040 Huntington's disease 3.41 map00620 Pyruvate metabolism 3.31 map00710 Carbon fixation 3.12 map00720 Reductive carboxylate cycle (CO2 fixation) 3.12 map00020 Citrate cycle (TCA cycle) 3.02 map00630 Glyoxylate and dicarboxylate metabolism 2.53 map00190 Oxidative phosphorylation 1.85 map00920 Sulfur metabolism 1.75 map04920 Adipocytokine signaling pathway 1.75 map04910 Insulin signaling pathway 1.07 map00272 Cysteine metabolism 0.88 map00051 Fructose and mannose metabolism 0.29 map02020 Two-component system - General 0.29 map03010 Ribosome 0.19 map00650 Butanoate metabolism 0.10 map00910 Nitrogen metabolism 0.10 map00040 Pentose and glucuronate interconversions 0.10 map00790 Folate biosynthesis 0.10 map00071 Fatty acid metabolism 0.10 map00632 Benzoate degradation via CoA ligation 0.10 map00740 Riboflavin metabolism 0.10 map03020 RNA polymerase 0.10 map02060 Phosphotransferase system (PTS) 0.10 map00280 Valine, leucine and isoleucine degradation 0.10 map00240 Pyrimidine metabolism 0.10 map00072 Synthesis and degradation of ketone bodies 0.10 map00310 Lysine degradation 0.10 map01051 Biosynthesis of ansamycins 0.10 map00500 Starch and sucrose metabolism 0.10 map00380 Tryptophan metabolism 0.10 map00480 Glutathione metabolism 0.10 map00640 Propanoate metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with CBS domain which could be assigned to a KEGG orthologous group, and not all proteins containing CBS domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of CBS domains in PDB
PDB code Main view Title 1ak5 INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) FROM TRITRICHOMONAS FOETUS 1b3o TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE 1jcn BINARY COMPLEX OF HUMAN TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP 1jr1 Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid 1me7 Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP and MOA bound 1me8 Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP bound 1me9 Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP bound 1meh Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound 1mei Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and mycophenolic acid bound 1mew Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and NAD bound 1nf7 Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide 1nfb Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD 1o50 Crystal structure of a cbs domain-containing protein (tm0935) from thermotoga maritima at 1.87 A resolution 1pbj CBS domain protein 1pvm Crystal Structure of a Conserved CBS Domain Protein TA0289 of Unknown Function from Thermoplasma acidophilum 1vr9 CRYSTAL STRUCTURE OF A CBS DOMAIN PAIR/ACT DOMAIN PROTEIN (TM0892) FROM THERMOTOGA MARITIMA AT 1.70 A RESOLUTION 1vrd Crystal structure of Inosine-5'-monophosphate dehydrogenase (TM1347) from THERMOTOGA MARITIMA at 2.18 A resolution 1xkf Crystal structure of Hypoxic Response Protein I (HRPI) with two coordinated zinc ions 1y5h Crystal structure of truncated Se-Met Hypoxic Response Protein I (HRPI) 1zfj INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH; EC 1.1.1.205) FROM STREPTOCOCCUS PYOGENES 2cu0 Crystal structure of inosine-5'-monophosphate dehydrogenase from Pyrococcus horikoshii OT3 2d4z Crystal structure of the cytoplasmic domain of the chloride channel ClC-0 2ef7 Crystal structure of ST2348, a hypothetical protein with CBS domains from Sulfolobus tokodaii strain7 2emq Hypothetical Conserved Protein (GK1048) from Geobacillus Kaustophilus 2j9l Cytoplasmic Domain of the Human Chloride Transporter ClC-5 in complex with ATP 2ja3 Cytoplasmic Domain of the Human Chloride Transporter ClC-5 in complex with ADP 2nyc Crystal structure of the Bateman2 domain of yeast Snf4 2nye Crystal structure of the Bateman2 domain of yeast Snf4 2o16 Crystal structure of a putative acetoin utilization protein (AcuB) from Vibrio cholerae 2oox Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP 2ooy Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with ATP 2oux Crystal structure of the soluble part of a magnesium transporter 2p9m Crystal structure of conserved hypothetical protein MJ0922 from Methanocaldococcus jannaschii DSM 2661 2pfi Crystal structure of the cytoplasmic domain of the human chloride channel ClC-Ka 2qh1 Structure of TA289, a CBS-rubredoxin-like protein, in its Fe+2-bound state 2qlv Crystal structure of the heterotrimer core of the S. cerevisiae AMPK homolog SNF1 2qr1 Crystal structure of the adenylate sensor from AMP-activated protein kinase in complex with ADP 2qrc Crystal structure of the adenylate sensor from AMP-activated protein kinase in complex with ADP and AMP 2qrd Crystal Structure of the Adenylate Sensor from AMP-activated Protein Kinase in complex with ADP and ATP 2qre Crystal structure of the adenylate sensor from AMP-activated protein kinase in complex with 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranotide (ZMP) 2rc3 Crystal structure of CBS domain, NE2398 2rif CBS domain protein PAE2072 from Pyrobaculum aerophilum complexed with AMP 2rih CBS domain protein PAE2072 from Pyrobaculum aerophilum 2uv4 Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP 2uv5 Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP 2uv6 Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP 2uv7 Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP 2v8q Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP 2v92 Crystal structure of the regulatory fragment of mammalian AMPK in complexes with ATP-AMP 2v9j Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP 2y8l Structure of an active form of mammalian AMPK in complex with two ADP 2y8q Structure of the regulatory fragment of mammalian AMPK in complex with one ADP 2ya3 STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP 2yvx Crystal structure of magnesium transporter MgtE 2yvy Crystal structure of magnesium transporter MgtE cytosolic domain, Mg2+ bound form 2yvz Crystal structure of magnesium transporter MgtE cytosolic domain, Mg2+-free form 2yzi Crystal structure of uncharacterized conserved protein from Pyrococcus horikoshii 2yzq Crystal structure of uncharacterized conserved protein from Pyrococcus horikoshii 2zy9 Improved crystal structure of magnesium transporter MgtE 3ddj Crystal structure of a cbs domain-containing protein in complex with amp (sso3205) from sulfolobus solfataricus at 1.80 A resolution 3fhm Crystal structure of the CBS-domain containing protein ATU1752 from Agrobacterium tumefaciens 3fv6 Crystal Structure of the CBS domains from the Bacillus subtilis CcpN repressor 3fwr Crystal Structure of the CBS domains from the Bacillus subtilis CcpN repressor complexed with ADP 3fws Crystal Structure of the CBS domains from the Bacillus subtilis CcpN repressor complexed with AppNp, phosphate and magnesium ions 3ghd Crystal structure of a cystathionine beta-synthase domain protein fused to a Zn-ribbon-like domain 3hf7 The Crystal Structure of a CBS-domain Pair with Bound AMP from Klebsiella pneumoniae to 2.75A 3i8n A domain of a conserved functionally known protein from Vibrio parahaemolyticus RIMD 2210633. 3jtf The CBS Domain Pair Structure of a magnesium and cobalt efflux protein from Bordetella parapertussis in complex with AMP 3k6e Crystal structure of cbs domain protein from streptococcus pneumoniae tigr4 3kh5 Crystal Structure of Protein MJ1225 from Methanocaldococcus jannaschii, a putative archaeal homolog of g-AMPK. 3kpb Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine. 3kpc Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine 3kpd Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine. 3kxr Structure of the cystathionine beta-synthase pair domain of the putative Mg2+ transporter SO5017 from Shewanella oneidensis MR-1. 3l2b Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with activator, diadenosine tetraphosphate 3l31 Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP 3lfr The Crystal Structure of a CBS Domain from a Putative Metal Ion Transporter Bound to AMP from Pseudomonas syringae to 1.55A 3lfz Crystal Structure of Protein MJ1225 from Methanocaldococcus jannaschii, a putative archaeal homolog of g-AMPK. 3lqn Crystal Structure of CBS Domain-containing Protein of Unknown Function from Bacillus anthracis str. Ames Ancestor 3lv9 Crystal structure of CBS domain of a putative transporter from Clostridium difficile 630 3nqr A putative CBS domain-containing protein from Salmonella typhimurium LT2 3oco The crystal structure of a Hemolysin-like protein containing CBS domain of Oenococcus oeni PSU 3oi8 The crystal structure of functionally unknown conserved protein domain from Neisseria meningitidis MC58 3pc2 Full length structure of cystathionine beta-synthase from Drosophila 3pc3 Full length structure of cystathionine beta-synthase from Drosophila in complex with aminoacrylate 3pc4 Full length structure of cystathionine beta-synthase from Drosophila in complex with serine 3sl7 Crystal structure of CBS-pair protein, CBSX2 from Arabidopsis thaliana 3t4n Structure of the regulatory fragment of Saccharomyces cerevisiae AMPK in complex with ADP 3tdh Structure of the regulatory fragment of sccharomyces cerevisiae AMPK in complex with AMP 3te5 structure of the regulatory fragment of sacchromyces cerevisiae ampk in complex with NADH 3tsb Crystal Structure of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis str. Ames 3tsd Crystal Structure of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis str. Ames complexed with XMP 3usb Crystal Structure of Bacillus anthracis Inosine Monophosphate Dehydrogenase in the complex with IMP 3zfh Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase 4af0 Crystal structure of cryptococcal inosine monophosphate dehydrogenase 4avf Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase 4cfe Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991) 4cff Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662) 4cfh Structure of an active form of mammalian AMPK 4coo Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution 4dqw Crystal Structure Analysis of PA3770 4eag Co-crystal structure of an chimeric AMPK core with ATP 4eai Co-crystal structure of an AMPK core with AMP 4eaj Co-crystal of AMPK core with AMP soaked with ATP 4eak Co-crystal structure of an AMPK core with ATP 4eal Co-crystal of AMPK core with ATP soaked with AMP 4esy Crystal Structure of the CBS Domain of CBS Domain Containing Membrane Protein from Sphaerobacter thermophilus 4fry The structure of a putative signal-transduction protein with CBS domains from Burkholderia ambifaria MC40-6 4fxs Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae complexed with IMP and mycophenolic acid 4gqv Crystal structure of CBS-pair protein, CBSX1 from Arabidopsis thaliana 4gqw Crystal structure of CBS-pair protein, CBSX1 (loop deletion) from Arabidopsis thaliana 4gqy Crystal structure of CBSX2 in complex with AMP 4hg0 Crystal Structure of magnesium and cobalt efflux protein CorC, Northeast Structural Genomics Consortium (NESG) Target ER40 4l0d Crystal structure of delta516-525 human cystathionine beta-synthase containing C-terminal 6xHis-tag 4l27 Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag 4l28 Crystal structure of delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag 4l3v Crystal structure of delta516-525 human cystathionine beta-synthase 4noc The crystal structure of a CBS Domain-containing Protein of Unknown Function from Kribbella flavida DSM 17836. 4o9k Crystal structure of the CBS pair of a putative D-arabinose 5-phosphate isomerase from Methylococcus capsulatus in complex with CMP-Kdo 4pcu 4PCU 4qfg 4QFG 4qfr 4QFR 4qfs 4QFS 4rer 4RER 4rew 4REW 4uuu 4UUU 4z87 4Z87 4zhx 4ZHX 5ahn 5AHN 5awe 5AWE 5ezv 5EZV 5iip 5IIP 5kq5 5KQ5 5ks7 5KS7 - Links (links to other resources describing this domain)
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INTERPRO IPR000644