The domain within your query sequence starts at position 417 and ends at position 522; the E-value for the DIL domain shown below is 2.47e-51.



SMART accession number:SM01132
Description: The DIL domain has no known function.
Interpro abstract (IPR002710):

The myosin superfamily consists of at least 15 distinct classes of presumed actin-based molecular motors. All members of the superfamily share a similar motor domain and a tail portion which is diagnostic of the class [ (PUBMED:11212352) ].

Class V myosins are actin-based molecular motors that function in relatively long-range movements of many intracellular cargoes including organelles, membrane vesicles, and mRNA [ (PUBMED:10931864) ]. These motors are ubiquitously found in all eukaryotes. Class V myosins are characterised by the presence of a conserved globular domain at the C terminus of the tail portion: the dilute domain [ (PUBMED:7667878) ]. Myosin V moves via attachment of its amino terminal head (motor) domain to actin cables; its carboxyl terminal dilute domain anchors it to cargoes via attachments to organelle-specific receptors [ (PUBMED:10931864) (PUBMED:15684027) ].

The dilute domain is also found in the afadin family. Afadins are nectin and actin filament-binding proteins that connect nectin to the actin cytoskeleton [ (PUBMED:12456712) ]. The dilute domain of afadin appears to be responsible for actin stress fibre formation [ (PUBMED:25712270) ].

Family alignment:
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There are 6872 DIL domains in 6863 proteins in SMART's nrdb database.

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