The domain within your query sequence starts at position 67 and ends at position 95; the E-value for the EFh domain shown below is 4.06e-2.

VILDIFRRADKNDDGKLSLEEFQLFFADG

EFh

EF-hand, calcium binding motif

• SMART accession number: SM00054
• Description: EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.
• Interpro abstract (IPR002048):

  Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both sides by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). Ca2 binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers [ (PUBMED:9228939) (PUBMED:8848832) (PUBMED:7553064) (PUBMED:7656053) (PUBMED:10591109) ].

• GO function: calcium ion binding (GO:0005509)

There are 343947 EFh domains in 122495 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Binding / catalysis: Ca2+-binding

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Kretsinger RH
• EF-hands embrace.
• Nat Struct Biol. 1997; 4: 514-6

• Ikura M
• Calcium binding and conformational response in EF-hand proteins.
• Trends Biochem Sci. 1996; 21: 14-7

EF-hand proteins undergo conformational changes upon binding of Ca2+. This event is a crucial step in many Ca2+-dependent cellular processes. Recent advances in the three-dimensional structural analysis of various EF-hand proteins have led to new insights into the structure and functional relationship of this large family of Ca2+-binding proteins.

• Schafer BW, Heizmann CW
• The S100 family of EF-hand calcium-binding proteins: functions and pathology.
• Trends Biochem Sci. 1996; 21: 134-40

Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.

• Akke M, Forsen S, Chazin WJ
• Solution structure of (Cd2+)1-calbindin D9k reveals details of the stepwise structural changes along the Apo-->(Ca2+)II1-->(Ca2+)I,II2 binding pathway.
• J Mol Biol. 1995; 252: 102-21

The three-dimensional solution structure of (Cd2+)1-calbindin D9k has been determined by distance geometry, restrained molecular dynamics and relaxation matrix calculations using experimental constraints obtained from two-dimensional 1H and 15N-1H NMR spectroscopy. The final input data consisted of 1055 NOE distance constraints and 71 dihedral angle constraints, corresponding to 15 constraints per residue on average. The resulting ensemble of 24 structures has no distance or dihedral angle constraints consistently violated by more than 0.07 A and 1.8 degrees, respectively. The structure is characteristic of an EF-hand protein, with two helix-loop-helix calcium binding motifs joined by a flexible linker, and a short anti-parallel beta-type interaction between the two ion-binding sites. The four helices are well defined with a root mean square deviation from the mean coordinates of 0.35 A for the backbone atoms. The structure of the half-saturated cadmium state was compared with the previously determined solution structures of the apo and fully calcium saturated calbindin D9k. The comparisons were aided by introducing the ensemble averaged distance difference matrix as a tool for analyzing differences between two ensembles of structures. Detailed analyses of differences between the three states in backbone and side-chain dihedral angles, hydrogen bonds, interatomic distances, and packing of the hydrophobic core reveal the reorganization of the protein that occurs upon ion binding. Overall, it was found that (Cd2+)1-calbindin D9k, representing the half-saturated calcium state with an ion in site II, is structurally more similar to the fully calcium-saturated state than the apo state. Thus, for the binding sequence apo-->(Ca2+)II1-->(Ca2+)I,II2, the structural changes occurring upon ion binding are most pronounced for the first binding step, an observation that bears significantly on the molecular basis for cooperative calcium binding in calbindin D9k.

• Kawasaki H, Kretsinger RH
• Calcium-binding proteins 1: EF-hands.
• Protein Profile. 1995; 2: 297-490

• Potts BC et al.
• The structure of calcyclin reveals a novel homodimeric fold for S100 Ca(2+)-binding proteins.
• Nat Struct Biol. 1995; 2: 790-6

The S100 calcium-binding proteins are implicated as effectors in calcium-mediated signal transduction pathways. The three-dimensional structure of the S100 protein calcyclin has been determined in solution in the apo state by NMR spectroscopy and a computational strategy that incorporates a systematic docking protocol. This structure reveals a symmetric homodimeric fold that is unique among calcium-binding proteins. Dimerization is mediated by hydrophobic contacts from several highly conserved residues, which suggests that the dimer fold identified for calcyclin will serve as a structural paradigm for the S100 subfamily of calcium-binding proteins.

• Skelton NJ, Kordel J, Chazin WJ
• Determination of the solution structure of Apo calbindin D9k by NMR spectroscopy.
• J Mol Biol. 1995; 249: 441-62

The three-dimensional structure of apo calbindin D9k has been determined using constraints generated from nuclear magnetic resonance spectroscopy. The family of solution structures was calculated using a combination of distance geometry, restrained molecular dynamics, and hybrid relaxation matrix analysis of the nuclear Overhauser effect (NOE) cross-peak intensities. Errors and inconsistencies in the input constraints were identified using complete relaxation matrix analyses based on the results of preliminary structure calculations. The final input data consisted of 994 NOE distance constraints and 122 dihedral constraints, aided by the stereospecific assignment of the resonances from 21 beta-methylene groups and seven isopropyl groups of leucine and valine residues. The resulting family of 33 structures contain no violation of the distance constraints greater than 0.17 A or of the dihedral angle constraints greater than 10 degrees. The structures consist of a well-defined, antiparallel four-helix bundle, with a short anti-parallel beta-interaction between the two unoccupied calcium-binding loops. The root-mean-square deviation from the mean structure of the backbone heavy-atoms for the well-defined helical residues is 0.55 A. The remainder of the ion-binding loops, the linker loop connecting the two sub-domains of the protein, and the N and C termini exhibit considerable disorder between different structures in the ensemble. A comparison with the structure of the (Ca2+)2 state indicates that the largest changes associated with ion-binding occur in the middle of helix IV and in the packing of helix III onto the remainder of the protein. The change in conformation of these helices is associated with a subtle reorganization of many residues in the hydrophobic core, including some side-chains that are up to 15 A from the ion-binding site.

• Slupsky CM, Kay CM, Reinach FC, Smillie LB, Sykes BD
• Calcium-induced dimerization of troponin C: mode of interaction and use of trifluoroethanol as a denaturant of quaternary structure.
• Biochemistry. 1995; 34: 7365-75

Protein aggregation can be a problem, especially as a large number of proteins become available for structural studies at fairly high concentrations using solution techniques such as NMR spectroscopy. The muscle regulatory protein troponin C (TnC) undergoes a calcium-induced dimerization at neutral pH with a dissociation constant for the dimerization of 0.4 mM at 20 degrees C. The present study indicates that the mode of dimerization involves the N-domain of one monomer interacting with the N-domain of another monomer. Addition of the solvent trifluoroethanol (TFE) to a concentration of 15%, v/v, results in a 10-fold increase in the dimer dissociation constant of calcium-saturated TnC (4 mM at 20 degrees C), making TnC predominantly a monomer for spectroscopic studies. Further, TFE, at the concentrations used herein, acts to perturb the quaternary structure of TnC without adversely affecting the secondary or tertiary structure as evidenced by minimal changes to its CD spectra and 1H, 13C, and 15N NMR chemical shifts.

• Slupsky CM, Reinach FC, Smillie LB, Sykes BD
• Solution secondary structure of calcium-saturated troponin C monomer determined by multidimensional heteronuclear NMR spectroscopy.
• Protein Sci. 1995; 4: 1279-90

The solution secondary structure of calcium-saturated skeletal troponin C (TnC) in the presence of 15% (v/v) trifluoroethanol (TFE), which has been shown to exist predominantly as a monomer (Slupsky CM, Kay CM, Reinach FC, Smillie LB, Sykes BD, 1995, Biochemistry 34, forthcoming), has been investigated using multidimensional heteronuclear nuclear magnetic resonance spectroscopy. The 1H, 15N, and 13C NMR chemical shift values for TnC in the presence of TFE are very similar to values obtained for calcium-saturated NTnC (residues 1-90 of skeletal TnC), calmodulin, and synthetic peptide homodimers. Moreover, the secondary structure elements of TnC are virtually identical to those obtained for calcium-saturated NTnC, calmodulin, and the synthetic peptide homodimers, suggesting that 15% (v/v) TFE minimally perturbs the secondary and tertiary structure of this stably folded protein. Comparison of the solution structure of calcium-saturated TnC with the X-ray crystal structure of half-saturated TnC reveals differences in the phi/psi angles of residue Glu 41 and in the linker between the two domains. Glu 41 has irregular phi/psi angles in the crystal structure, producing a kink in the B helix, whereas in calcium-saturated TnC, Glu 41 has helical phi/psi angles, resulting in a straight B helix. The linker between the N and C domains of calcium-saturated TnC is flexible in the solution structure.

• Gagne SM, Tsuda S, Li MX, Chandra M, Smillie LB, Sykes BD
• Quantification of the calcium-induced secondary structural changes in the regulatory domain of troponin-C.
• Protein Sci. 1994; 3: 1961-74

The backbone resonance assignments have been completed for the apo (1H and 15N) and calcium-loaded (1H, 15N, and 13C) regulatory N-domain of chicken skeletal troponin-C (1-90), using multidimensional homonuclear and heteronuclear NMR spectroscopy. The chemical-shift information, along with detailed NOE analysis and 3JHNH alpha coupling constants, permitted the determination and quantification of the Ca(2+)-induced secondary structural change in the N-domain of TnC. For both structures, 5 helices and 2 short beta-strands were found, as was observed in the apo N-domain of the crystal structure of whole TnC (Herzberg O, James MNG, 1988, J Mol Biol 203:761-779). The NMR solution structure of the apo form is indistinguishable from the crystal structure, whereas some structural differences are evident when comparing the 2Ca2+ state solution structure with the apo one. The major conformational change observed is the straightening of helix-B upon Ca2+ binding. The possible importance and role of this conformational change is explored. Previous CD studies on the regulatory domain of TnC showed a significant Ca(2+)-induced increase in negative ellipticity, suggesting a significant increase in helical content upon Ca2+ binding. The present study shows that there is virtually no change in alpha-helical content associated with the transition from apo to the 2Ca2+ state of the N-domain of TnC. Therefore, the Ca(2+)-induced increase in ellipticity observed by CD does not relate to a change in helical content, but more likely to changes in spatial orientation of helices.

• Skelton NJ, Kordel J, Akke M, Forsen S, Chazin WJ
• Signal transduction versus buffering activity in Ca(2+)-binding proteins.
• Nat Struct Biol. 1994; 1: 239-45

The three-dimensional structure of calbindin D9k in the absence of Ca2+ has been determined using NMR spectroscopy in solution, allowing the first direct analysis of the consequences of Ca2+ binding for a member of the calmodulin superfamily of proteins. The overall response in calbindin D9k is much attenuated relative to the current model for calmodulin and troponin C. These results demonstrate a novel mechanism for modulating the conformational response to Ca(2+)-binding in calmodulin superfamily proteins and provide insights into how their Ca(2+)-binding domains can be fine-tuned to remain essentially intact or respond strongly to ion binding, in relation to their functional requirements.

• Kordel J, Skelton NJ, Akke M, Chazin WJ
• High-resolution structure of calcium-loaded calbindin D9k.
• J Mol Biol. 1993; 231: 711-34

The three-dimensional solution structure of calcium-loaded calbindin D9k has been determined using experimental constraints obtained from nuclear magnetic resonance spectroscopy. A total of 1176 constraints (16 per residue overall, 32 per residue for the core residues) was used for the final refinement, including 1002 distance and 174 dihedral angle constraints. In addition, 23 hydrogen bond constraints were used for the generation of initial structures. Stereospecific assignments were made for 37 of 61 (61%) prochiral methylene protons and the methyl groups of all three valine residues and five out of 12 leucine residues. These constraints were used as input for a series of calculations of three-dimensional structures using a combination of distance geometry and restrained molecular dynamics. The 33 best structures selected for further analysis have no distance constraint violations greater than 0.3 A and good local geometries as reflected by low total energies (< or = -1014 kcal/mol in the AMBER 4.0 force field). The core of the protein consists of four well-defined helices with root-mean-square deviations from the average of 0.45 A for the N, C alpha and C' backbone atoms. These helices are packed in an antiparallel fashion to form two helix-loop-helix calcium-binding motifs, termed EF-hands. The two EF-hands are joined at one end by a ten-residue linker segment, and at the other by a short beta-type interaction between the two calcium-binding loops. Overall, the average solution structure of calbindin D9k is very similar to the crystal structure, with a pairwise root-mean-square deviation of 0.85 A for the N, C alpha and C' backbone atoms of the four helices. The differences that are observed between the solution and the crystal structures are attributed to specific crystal contacts, increased side-chain flexibility in solution, or artifacts arising from molecular dynamics refinement of the solution structures in vacuo.

• Watterson DM, HarrelsonWGJ r, Keller PM, Sharief F, Vanaman TC
• Structural similarities between the Ca2+-dependent regulatory proteins of 3':5'-cyclic nucleotide phosphodiesterase and actomyosin ATPase.
• J Biol Chem. 1976; 251: 4501-13

Results of studies of the Ca2+-dependent protein modulator of 3':5'-cyclic nucleotide phosphodiesterase isolated from bovine brain are presented which show its structural similarity to the Ca2+-binding subunit of muscle troponin. Both proteins have blocked NH2 termini, similar and characteristic ultraviolet absorption spectra, similar Ca2+-binding properties, very similar amino acid compositions, and co-migrate on sodium dodecyl sulfate-polyacrylamide gels. The primary structures of selected tryptic peptides isolated from bovine brain modulator protein are similar or identical with regions of the primary sequences of rabbit skeletal muscle and bovine cardiac muscle troponin C. Bovine brain modulator protein contains and unidentified ninhydrin-positive basic compound not found in muscle troponin C. An improved procedure is presented which yields 40 to 70 mg of modulator protein per kg of bovine brain.

• Kretsinger RH
• Gene triplication deduced from the tertiary structure of a muscle calcium binding protein.
• Nat New Biol. 1972; 240: 85-8

• McLachlan AD
• Gene duplication in carp muscle calcium binding protein.
• Nat New Biol. 1972; 240: 83-5

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the EFh domain.

Protein	Disease
Calpain-3 (P20807) (SMART)	OMIM:114240: Muscular dystrophy, limb-girdle, type 2A OMIM:253600:

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
8.58	map04020	Calcium signaling pathway
7.04	map04510	Focal adhesion
6.27	map04810	Regulation of actin cytoskeleton
6.27	map04530	Tight junction
6.01	map04070	Phosphatidylinositol signaling system
5.41	map04720	Long-term potentiation
4.72	map04740	Olfactory transduction
4.12	map04210	Apoptosis
3.52	map04010	MAPK signaling pathway
3.26	map04670	Leukocyte transendothelial migration
3.00	map04520	Adherens junction
2.92	map05214	Glioma
2.92	map04916	Melanogenesis
2.92	map04912	GnRH signaling pathway
2.92	map04910	Insulin signaling pathway
2.92	map05040	Huntington's disease
2.83	map00562	Inositol phosphate metabolism
2.75	map00564	Glycerophospholipid metabolism
2.49	map04370	VEGF signaling pathway
2.49	map04662	B cell receptor signaling pathway
2.49	map04310	Wnt signaling pathway
2.49	map04360	Axon guidance
2.49	map04660	T cell receptor signaling pathway
2.49	map04650	Natural killer cell mediated cytotoxicity
1.72	map00561	Glycerolipid metabolism
1.63	map00632	Benzoate degradation via CoA ligation
0.77	map00030	Pentose phosphate pathway
0.26	map00190	Oxidative phosphorylation
0.26	map00360	Phenylalanine metabolism
0.17	map00350	Tyrosine metabolism
0.17	map00340	Histidine metabolism
0.17	map00642	Ethylbenzene degradation
0.17	map00903	Limonene and pinene degradation
0.17	map00960	Alkaloid biosynthesis II
0.17	map00310	Lysine degradation
0.17	map00624	1- and 2-Methylnaphthalene degradation
0.17	map00230	Purine metabolism
0.09	map00940	Phenylpropanoid biosynthesis
0.09	map00650	Butanoate metabolism
0.09	map00680	Methane metabolism
0.09	map00280	Valine, leucine and isoleucine degradation
0.09	map00072	Synthesis and degradation of ketone bodies
0.09	map00361	gamma-Hexachlorocyclohexane degradation
0.09	map00627	1,4-Dichlorobenzene degradation
0.09	map00364	Fluorobenzoate degradation

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EFh domain which could be assigned to a KEGG orthologous group, and not all proteins containing EFh domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of EFh domains in PDB

PDB code	Title
1a29	CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)
1a2x	COMPLEX OF TROPONIN C WITH A 47 RESIDUE (1-47) FRAGMENT OF TROPONIN I
1a75	WHITING PARVALBUMIN
1ahr	CALMODULIN MUTANT WITH A TWO RESIDUE DELETION IN THE CENTRAL HELIX
1aj4	STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 1 STRUCTURE
1aj5	CALPAIN DOMAIN VI APO
1ak8	NMR SOLUTION STRUCTURE OF CERIUM-LOADED CALMODULIN AMINO-TERMINAL DOMAIN (CE2-TR1C), 23 STRUCTURES
1alv	CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN
1alw	INHIBITOR AND CALCIUM BOUND DOMAIN VI OF PORCINE CALPAIN
1ap4	REGULATORY DOMAIN OF HUMAN CARDIAC TROPONIN C IN THE CALCIUM-SATURATED STATE, NMR, 40 STRUCTURES
1aui	HUMAN CALCINEURIN HETERODIMER
1avs	X-RAY CRYSTALLOGRAPHIC STUDY OF CALCIUM-SATURATED N-TERMINAL DOMAIN OF TROPONIN C
1b7t	MYOSIN DIGESTED BY PAPAIN
1b8r	PARVALBUMIN
1b9a	PARVALBUMIN (MUTATION;D51A, F102W)
1bjf	CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS
1blq	STRUCTURE AND INTERACTION SITE OF THE REGULATORY DOMAIN OF TROPONIN-C WHEN COMPLEXED WITH THE 96-148 REGION OF TROPONIN-I, NMR, 29 STRUCTURES
1boc	THE SOLUTION STRUCTURES OF MUTANT CALBINDIN D9K'S, AS DETERMINED BY NMR, SHOW THAT THE CALCIUM BINDING SITE CAN ADOPT DIFFERENT FOLDS
1bod	THE SOLUTION STRUCTURES OF MUTANT CALBINDIN D9K'S, AS DETERMINED BY NMR, SHOW THAT THE CALCIUM BINDING SITE CAN ADOPT DIFFERENT FOLDS
1br1	SMOOTH MUSCLE MYOSIN MOTOR DOMAIN-ESSENTIAL LIGHT CHAIN COMPLEX WITH MGADP.ALF4 BOUND AT THE ACTIVE SITE
1br4	SMOOTH MUSCLE MYOSIN MOTOR DOMAIN-ESSENTIAL LIGHT CHAIN COMPLEX WITH MGADP.BEF3 BOUND AT THE ACTIVE SITE
1bu3	REFINED CRYSTAL STRUCTURE OF CALCIUM-BOUND SILVER HAKE (PI 4.2) PARVALBUMIN AT 1.65 A.
1c7v	NMR SOLUTION STRUCTURE OF THE CALCIUM-BOUND C-TERMINAL DOMAIN (W81-S161) OF CALCIUM VECTOR PROTEIN FROM AMPHIOXUS
1c7w	NMR SOLUTION STRUCTURE OF THE CALCIUM-BOUND C-TERMINAL DOMAIN (W81-S161) OF CALCIUM VECTOR PROTEIN FROM AMPHIOXUS
1cdl	TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX
1cdm	MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES
1cdp	RESTRAINED LEAST SQUARES REFINEMENT OF NATIVE (CALCIUM) AND CADMIUM-SUBSTITUTED CARP PARVALBUMIN USING X-RAY CRYSTALLOGRAPHIC DATA AT 1.6-ANGSTROMS RESOLUTION
1cfc	CALCIUM-FREE CALMODULIN
1cfd	CALCIUM-FREE CALMODULIN
1cff	NMR SOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THE CA2+-PUMP
1ckk	CALMODULIN/RAT CA2+/CALMODULIN DEPENDENT PROTEIN KINASE FRAGMENT
1cll	CALMODULIN STRUCTURE REFINED AT 1.7 ANGSTROMS RESOLUTION
1clm	STRUCTURE OF PARAMECIUM TETRAURELIA CALMODULIN AT 1.8 ANGSTROMS RESOLUTION
1cm1	MOTIONS OF CALMODULIN-SINGLE-CONFORMER REFINEMENT
1cm4	MOTIONS OF CALMODULIN-FOUR-CONFORMER REFINEMENT
1cmf	NMR SOLUTION STRUCTURE OF APO CALMODULIN CARBOXY-TERMINAL DOMAIN
1cmg	NMR SOLUTION STRUCTURE OF CALCIUM-LOADED CALMODULIN CARBOXY-TERMINAL DOMAIN
1ctr	DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX
1deg	THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE
1df0	Crystal structure of M-Calpain
1dfk	NUCLEOTIDE-FREE SCALLOP MYOSIN S1-NEAR RIGOR STATE
1dfl	SCALLOP MYOSIN S1 COMPLEXED WITH MGADP:VANADATE-TRANSITION STATE
1dgu	HOMOLOGY-BASED MODEL OF CALCIUM-SATURATED CIB (CALCIUM-AND INTEGRIN-BINDING PROTEIN)
1dgv	HOMOLOGY-BASED MODEL OF APO CIB (CALCIUM-AND INTEGRIN-BINDING PROTEIN)
1djg	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH LANTHANUM
1djh	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH BARIUM
1dji	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH CALCIUM
1djw	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHONATE
1djx	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-1,4,5-TRISPHOSPHATE
1djy	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2,4,5-TRISPHOSPHATE
1djz	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-4,5-BISPHOSPHATE
1dmo	CALMODULIN, NMR, 30 STRUCTURES
1dtl	CRYSTAL STRUCTURE OF CALCIUM-SATURATED (3CA2+) CARDIAC TROPONIN C COMPLEXED WITH THE CALCIUM SENSITIZER BEPRIDIL AT 2.15 A RESOLUTION
1dvi	CALPAIN DOMAIN VI WITH CALCIUM BOUND
1ej3	CRYSTAL STRUCTURE OF AEQUORIN
1el4	STRUCTURE OF THE CALCIUM-REGULATED PHOTOPROTEIN OBELIN DETERMINED BY SULFUR SAS
1exr	THE 1.0 ANGSTROM CRYSTAL STRUCTURE OF CA+2 BOUND CALMODULIN
1f4o	CRYSTAL STRUCTURE OF GRANCALCIN WITH BOUND CALCIUM
1f4q	CRYSTAL STRUCTURE OF APO GRANCALCIN
1f54	SOLUTION STRUCTURE OF THE APO N-TERMINAL DOMAIN OF YEAST CALMODULIN
1f55	SOLUTION STRUCTURE OF THE CALCIUM BOUND N-TERMINAL DOMAIN OF YEAST CALMODULIN
1f70	REFINED SOLUTION STRUCTURE OF CALMODULIN N-TERMINAL DOMAIN
1f71	REFINED SOLUTION STRUCTURE OF CALMODULIN C-TERMINAL DOMAIN
1fi5	NMR STRUCTURE OF THE C TERMINAL DOMAIN OF CARDIAC TROPONIN C BOUND TO THE N TERMINAL DOMAIN OF CARDIAC TROPONIN I.
1fpw	STRUCTURE OF YEAST FREQUENIN
1fw4	CRYSTAL STRUCTURE OF E. COLI FRAGMENT TR2C FROM CALMODULIN TO 1.7 A RESOLUTION
1g33	CRYSTAL STRUCTURE OF RAT PARVALBUMIN WITHOUT THE N-TERMINAL DOMAIN
1g4y	1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN
1g8i	CRYSTAL STRUCTURE OF HUMAN FREQUENIN (NEURONAL CALCIUM SENSOR 1)
1ggw	CDC4P FROM SCHIZOSACCHAROMYCES POMBE
1ggz	CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS
1gjy	The X-ray structure of the Sorcin Calcium Binding Domain (SCBD) provides insight into the phosphorylation and calcium dependent processess
1h4b	SOLUTION STRUCTURE OF THE BIRCH POLLEN ALLERGEN BET V 4
1hqv	STRUCTURE OF APOPTOSIS-LINKED PROTEIN ALG-2
1i84	CRYO-EM STRUCTURE OF THE HEAVY MEROMYOSIN SUBFRAGMENT OF CHICKEN GIZZARD SMOOTH MUSCLE MYOSIN WITH REGULATORY LIGHT CHAIN IN THE DEPHOSPHORYLATED STATE. ONLY C ALPHAS PROVIDED FOR REGULATORY LIGHT CHAIN. ONLY BACKBONE ATOMS PROVIDED FOR S2 FRAGMENT.
1ih0	Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033
1ij5	METAL-FREE STRUCTURE OF MULTIDOMAIN EF-HAND PROTEIN, CBP40, FROM TRUE SLIME MOLD
1ij6	CA2+-BOUND STRUCTURE OF MULTIDOMAIN EF-HAND PROTEIN, CBP40, FROM TRUE SLIME MOLD
1iku	MYRISTOYLATED RECOVERIN IN THE CALCIUM-FREE STATE, NMR, 22 STRUCTURES
1iq5	Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
1iwq	Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin
1j1d	Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form
1j1e	Crystal structure of the 52kDa domain of human cardiac troponin in the Ca2+ saturated form
1j7o	Solution structure of Calcium-calmodulin N-terminal domain
1j7p	Solution structure of Calcium calmodulin C-terminal domain
1jba	UNMYRISTOYLATED GCAP-2 WITH THREE CALCIUM IONS BOUND
1jc2	COMPLEX OF THE C-DOMAIN OF TROPONIN C WITH RESIDUES 1-40 OF TROPONIN I
1jf0	The Crystal Structure of Obelin from Obelia geniculata at 1.82 A Resolution
1jf2	Crystal Structure of W92F obelin mutant from Obelia longissima at 1.72 Angstrom resolution
1jfj	NMR SOLUTION STRUCTURE OF AN EF-HAND CALCIUM BINDING PROTEIN FROM ENTAMOEBA HISTOLYTICA
1jfk	MINIMUM ENERGY REPRESENTATIVE STRUCTURE OF A CALCIUM BOUND EF-HAND PROTEIN FROM ENTAMOEBA HISTOLYTICA
1jsa	MYRISTOYLATED RECOVERIN WITH TWO CALCIUMS BOUND, NMR, 24 STRUCTURES
1juo	Crystal Structure of Calcium-free Human Sorcin: A Member of the Penta-EF-Hand Protein Family
1k90	Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
1k93	Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin
1k94	Crystal structure of des(1-52)grancalcin with bound calcium
1k95	Crystal structure of des(1-52)grancalcin with bound calcium
1k9u	Crystal Structure of the Calcium-Binding Pollen Allergen Phl p 7 (Polcalcin) at 1.75 Angstroem
1kfu	Crystal Structure of Human m-Calpain Form II
1kfx	Crystal Structure of Human m-Calpain Form I
1kk7	SCALLOP MYOSIN IN THE NEAR RIGOR CONFORMATION
1kk8	SCALLOP MYOSIN (S1-ADP-BeFx) IN THE ACTIN-DETACHED CONFORMATION
1kqm	SCALLOP MYOSIN S1-AMPPNP IN THE ACTIN-DETACHED CONFORMATION
1kwo	SCALLOP MYOSIN S1-ATPgammaS-p-PDM IN THE ACTIN-DETACHED CONFORMATION
1l2o	SCALLOP MYOSIN S1-ADP-p-PDM IN THE ACTIN-DETACHED CONFORMATION
1l7z	Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide
1la0	Solution Structure of Calcium Saturated Cardiac Troponin C in the Troponin C-Troponin I Complex
1la3	Solution structure of recoverin mutant, E85Q
1lin	CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX)
1lkj	NMR Structure of Apo Calmodulin from Yeast Saccharomyces cerevisiae
1lvc	Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP
1lxf	Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac Troponin-I(147-163) and Bepridil
1m39	Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form
1m45	CRYSTAL STRUCTURE OF MLC1P BOUND TO IQ2 OF MYO2P, A CLASS V MYOSIN
1m46	CRYSTAL STRUCTURE OF MLC1P BOUND TO IQ4 OF MYO2P, A CLASS V MYOSIN
1m63	Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
1m8q	Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle
1mf8	Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
1mux	SOLUTION NMR STRUCTURE OF CALMODULIN/W-7 COMPLEX: THE BASIS OF DIVERSITY IN MOLECULAR RECOGNITION, 30 STRUCTURES
1mvw	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1mxe	Structure of the Complex of Calmodulin with the Target Sequence of CaMKI
1mxl	STRUCTURE OF CARDIAC TROPONIN C-TROPONIN I COMPLEX
1n0y	Crystal Structure of Pb-bound Calmodulin
1n2d	Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin
1ncx	TROPONIN C
1ncy	TROPONIN-C, COMPLEX WITH MANGANESE
1ncz	TROPONIN C
1niw	Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin
1np8	18-k C-terminally trunucated small subunit of calpain
1npq	structure of a rhodamine-labeled N-domain Troponin C mutant (Ca2+ saturated) in complex with skeletal Troponin I 115-131
1nwd	Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia Glutamate Decarboxylase
1nx0	Structure of Calpain Domain 6 in Complex with Calpastatin DIC
1nx1	Calpain Domain VI Complexed with Calpastatin Inhibitory Domain C (DIC)
1nx2	Calpain Domain VI
1nx3	Calpain Domain VI in Complex with the Inhibitor PD150606
1nya	NMR SOLUTION STRUCTURE OF CALERYTHRIN, AN EF-HAND CALCIUM-BINDING PROTEIN
1o18	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o19	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o1a	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o1b	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o1c	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o1d	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o1e	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o1f	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1o1g	MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
1oe9	Crystal structure of Myosin V nucleotide-free
1omd	STRUCTURE OF ONCOMODULIN REFINED AT 1.85 ANGSTROMS RESOLUTION. AN EXAMPLE OF EXTENSIVE MOLECULAR AGGREGATION VIA CA2+
1omr	non-myristoylated wild-type bovine recoverin with calcium bound to EF-hand 3
1omv	non-myristoylated bovine recoverin (E85Q mutant) with calcium bound to EF-hand 3
1ooj	Structural genomics of Caenorhabditis elegans : Calmodulin
1oqp	STRUCTURE OF THE CA2+/C-TERMINAL DOMAIN OF CALTRACTIN IN COMPLEX WITH THE CDC31P-BINDING DOMAIN FROM KAR1P
1osa	CRYSTAL STRUCTURE OF RECOMBINANT PARAMECIUM TETRAURELIA CALMODULIN AT 1.68 ANGSTROMS RESOLUTION
1ozs	C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I
1pal	IONIC INTERACTIONS WITH PARVALBUMINS. CRYSTAL STRUCTURE DETERMINATION OF PIKE 4.10 PARVALBUMIN IN FOUR DIFFERENT IONIC ENVIRONMENTS
1pk0	Crystal Structure of the EF3-CaM complexed with PMEApp
1prw	Crystal structure of bovine brain Ca++ calmodulin in a compact form
1pva	COMPARISON BETWEEN THE CRYSTAL AND THE SOLUTION STRUCTURES OF THE EF HAND PARVALBUMIN (ALPHA COMPONENT FROM PIKE MUSCLE)
1pvb	X-RAY STRUCTURE OF A NEW CRYSTAL FORM OF PIKE 4.10 PARVALBUMIN
1q80	Solution structure and dynamics of Nereis sarcoplasmic calcium binding protein
1qas	1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1
1qat	1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA COMPLEX WITH SAMARIUM (III) CHLORIDE
1qiv	CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-( 3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX
1qiw	CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-( 2 3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD)
1qs7	The 1.8 angstrom structure of calmodulin rs20 peptide complex
1qtx	THE 1.65 ANGSTROM STRUCTURE OF CALMODULIN RS20 PEPTIDE COMPLEX
1qv0	Atomic resolution structure of obelin from Obelia longissima
1qv1	Atomic resolution structure of obelin from Obelia longissima
1qvi	Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom resolution: flexibility and function in the head
1qx5	Crystal structure of apoCalmodulin
1qx7	Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel
1qxp	Crystal Structure of a mu-like calpain
1r2u	NMR structure of the N domain of trout cardiac troponin C at 30 C
1r6p	NMR structure of the N-terminal domain of trout cardiac troponin C at 7 C
1rec	THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION
1rfj	Crystal Structure of Potato Calmodulin PCM6
1rjv	Solution Structure of Human alpha-Parvalbumin refined with a paramagnetism-based strategy
1rk9	Solution Structure of Human alpha-Parvalbumin (Minimized Average Structure)
1rro	REFINEMENT OF RECOMBINANT ONCOMODULIN AT 1.30 ANGSTROMS RESOLUTION
1rtp	REFINED X-RAY STRUCTURE OF RAT PARVALBUMIN, A MAMMALIAN ALPHA-LINEAGE PARVALBUMIN, AT 2.0 A RESOLUTION
1rwy	CRYSTAL STRUCTURE OF RAT ALPHA-PARVALBUMIN AT 1.05 RESOLUTION
1s1e	Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)
1s26	Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex Reveals an Alternative Mode of ATP Binding to the Catalytic Site
1s36	Crystal structure of a Ca2+-discharged photoprotein: Implications for the mechanisms of the calcium trigger and the bioluminescence
1s3p	Crystal structure of rat alpha-parvalbumin S55D/E59D mutant
1s5g	Structure of Scallop myosin S1 reveals a novel nucleotide conformation
1s6c	Crystal structure of the complex between KChIP1 and Kv4.2 N1-30
1s6i	Ca2+-regulatory region (CLD) from soybean calcium-dependent protein kinase-alpha (CDPK) in the presence of Ca2+ and the junction domain (JD)
1s6j	N-terminal Region of the Ca2+-saturated calcium regulatory domain (CLD) from Soybean Calcium-dependent Protein Kinase-alpha (CDPK)
1sbj	NMR Structure of the Mg2+-loaded C Terminal Domain of Cardiac Troponin C Bound to the N Terminal Domain of Cardiac Troponin I
1scm	STRUCTURE OF THE REGULATORY DOMAIN OF SCALLOP MYOSIN AT 2.8 ANGSTROMS RESOLUTION
1scv	NMR STRUCTURE OF THE C TERMINAL DOMAIN OF CARDIAC TROPONIN C BOUND TO THE N TERMINAL DOMAIN OF CARDIAC TROPONIN I
1sjj	Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin
1sk6	Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate
1skt	SOLUTION STRUCTURE OF APO N-DOMAIN OF TROPONIN C, NMR, 40 STRUCTURES
1sl7	Crystal structure of calcium-loaded apo-obelin from Obelia longissima
1sl8	Calcium-loaded apo-aequorin from Aequorea victoria
1sl9	Obelin from Obelia longissima
1smg	CALCIUM-BOUND E41A MUTANT OF THE N-DOMAIN OF CHICKEN TROPONIN C, NMR, 40 STRUCTURES
1spy	REGULATORY DOMAIN OF HUMAN CARDIAC TROPONIN C IN THE CALCIUM-FREE STATE, NMR, 40 STRUCTURES
1sr6	Structure of nucleotide-free scallop myosin S1
1sw8	Solution structure of the N-terminal domain of Human N60D calmodulin refined with paramagnetism based strategy
1sy9	Structure of calmodulin complexed with a fragment of the olfactory CNG channel
1tcf	CRYSTAL STRUCTURE OF CALCIUM-SATURATED RABBIT SKELETAL TROPONIN C
1tco	TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
1tiz	Solution Structure of a Calmodulin-Like Calcium-Binding Domain from Arabidopsis thaliana
1tn4	FOUR CALCIUM TNC
1tnp	STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH
1tnq	STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH
1tnw	NMR SOLUTION STRUCTURE OF CALCIUM SATURATED SKELETAL MUSCLE TROPONIN C
1tnx	NMR SOLUTION STRUCTURE OF CALCIUM SATURATED SKELETAL MUSCLE TROPONIN C
1top	STRUCTURE OF CHICKEN SKELETAL MUSCLE TROPONIN-C AT 1.78 ANGSTROMS RESOLUTION
1trf	SOLUTION STRUCTURE OF THE TR1C FRAGMENT OF SKELETAL MUSCLE TROPONIN-C
1ttx	Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy
1u5i	Crystal Structure analysis of rat m-calpain mutant Lys10 Thr
1uhh	Crystal structure of cp-aequorin
1uhi	Crystal structure of i-aequorin
1uhj	Crystal structure of br-aequorin
1uhk	Crystal structure of n-aequorin
1uhn	The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana
1up5	Chicken Calmodulin
1v1f	Structure of the Arabidopsis thaliana SOS3 complexed with Calcium(II) and Manganese(II) ions
1v1g	Structure of the Arabidopsis thaliana SOS3 complexed with Calcium(II) ion
1vrk	THE 1.9 ANGSTROM STRUCTURE OF E84K-CALMODULIN RS20 PEPTIDE COMPLEX
1w7i	Crystal Structure Of Myosin V Motor Without nucleotide soaked in 10 mM MgADP
1w7j	Crystal Structure Of Myosin V Motor With Essential Light Chain + ADP-BeFx - Near Rigor
1wdc	SCALLOP MYOSIN REGULATORY DOMAIN
1wrk	Crystal structure of the N-terminal domain of human cardiac troponin C in complex with trifluoperazine (orthrombic crystal form)
1wrl	Crystal structure of the N-terminal domain of human cardiac troponin C in complex with trifluoperazine (monoclinic crystal form)
1wrz	Calmodulin complexed with a peptide from a human death-associated protein kinase
1x02	Solution structure of stereo array isotope labeled (SAIL) calmodulin
1xa5	Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
1xfu	Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
1xfv	Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
1xfw	Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)
1xfx	Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
1xfy	Crystal structure of anthrax edema factor (EF) in complex with calmodulin
1xfz	Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
1xo5	Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein
1xvj	Crystal Structure Of Rat alpha-Parvalbumin D94S/G98E Mutant
1y0v	Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
1y1a	CRYSTAL STRUCTURE OF CALCIUM AND INTEGRIN BINDING PROTEIN
1y1x	Structural analysis of a homolog of programmed cell death 6 protein from Leishmania major Friedlin
1y6w	Trapped intermediate of calmodulin
1yr5	1.7-A structure of calmodulin bound to a peptide from DAP kinase
1yrt	Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin
1yru	Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride
1ytz	Crystal structure of skeletal muscle troponin in the Ca2+-activated state
1yv0	Crystal structure of skeletal muscle troponin in the Ca2+-free state
1yx7	NMR structure of Calsensin, energy minimized average structure.
1yx8	NMR structure of Calsensin, 20 low energy structures.
1zac	N-DOMAIN OF TROPONIN C FROM CHICKEN SKELETAL MUSCLE, NMR, MINIMIZED AVERAGE STRUCTURE
1zmz	Solution structure of the N-terminal domain (M1-S98) of human centrin 2
1zot	crystal structure analysis of the CyaA/C-Cam with PMEAPP
1zuz	Calmodulin in complex with a mutant peptide from human DRP-1 kinase
2a4j	Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein
2aao	Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana
2ami	Solution Structure Of The Calcium-loaded N-Terminal Sensor Domain Of Centrin
2b1u	Solution structure of Calmodulin-like Skin Protein C terminal domain
2bbm	SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
2bbn	SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
2bcx	Crystal structure of calmodulin in complex with a ryanodine receptor peptide
2be4	X-RAY STRUCTURE AN EF-HAND PROTEIN FROM DANIO RERIO Dr.36843
2be6	2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex
2bec	Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation
2bkh	Myosin VI nucleotide-free (MDInsert2) crystal structure.
2bki	Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure
2bl0	Physarum polycephalum myosin II regulatory domain
2ccm	X-ray structure of Calexcitin from Loligo pealeii at 1.8A
2col	Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
2ct9	The crystal structure of calcineurin B homologous proein 1 (CHP1)
2ctn	STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES
2d8n	Crystal structure of human recoverin at 2.2 A resolution
2dfs	3-D structure of Myosin-V inhibited state
2doq	crystal structure of Sfi1p/Cdc31p complex
2e30	Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1
2e6w	Solution structure and calcium binding properties of EF-hands 3 and 4 of calsenilin
2ec6	Placopecten Striated Muscle Myosin II
2ehb	The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3
2f2o	Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
2f2p	Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
2f33	NMR solution structure of Ca2+-loaded calbindin D28K
2f3y	Calmodulin/IQ domain complex
2f3z	Calmodulin/IQ-AA domain complex
2f8p	Crystal structure of obelin following Ca2+ triggered bioluminescence suggests neutral coelenteramide as the primary excited state
2fce	Solution structure of C-lobe Myosin Light Chain from Saccharomices cerevisiae
2fot	Crystal structure of the complex between calmodulin and alphaII-spectrin
2g9b	NMR solution structure of CA2+-loaded calbindin D28K
2ggm	Human centrin 2 xeroderma pigmentosum group C protein complex
2ggz	Crystal Structure of Human Guanylate Cyclase Activating Protein-3
2gv5	crystal structure of Sfi1p/Cdc31p complex
2het	Non-myristoylated bovine recoverin (truncated at C-terminus) with calcium bound to EF-hand 3
2hf5	The structure and function of a novel two-site calcium-binding fragment of calmodulin
2hps	Crystal structure of coelenterazine-binding protein from Renilla Muelleri
2hq8	Crystal structure of coelenterazine-binding protein from renilla muelleri in the ca loaded apo form
2hqw	Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1 peptide
2i08	Solvation effect in conformational changes of EF-hand proteins: X-ray structure of Ca2+-saturated double mutant Q41L-K75I of N-domain of calmodulin
2i18	The refined structure of C-terminal domain of an EF-hand Calcium binding Protein from Entamoeba Histolytica
2i2r	Crystal structure of the KChIP1/Kv4.3 T1 complex
2i94	NMR Structure of recoverin bound to rhodopsin kinase
2isd	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT
2ix7	Structure of apo-calmodulin bound to unconventional myosin V
2jc2	The crystal structure of the natural F112L human sorcin mutant
2jnf	Solution structure of fly troponin C, isoform F1
2jnx	NMR derived solution structure of an EF-hand Calcium Binding Protein from Entamoeba Histolytica
2joj	NMR solution structure of N-terminal domain of Euplotes octocarinatus centrin
2jt0	Solution structure of F104W cardiac troponin C
2jt3	Solution Structure of F153W cardiac troponin C
2jt8	Solution structure of the F153-to-5-flurotryptophan mutant of human cardiac troponin C
2jtz	Solution structure and chemical shift assignments of the F104-to-5-flurotryptophan mutant of cardiac troponin C
2ju0	Structure of Yeast Frequenin bound to PdtIns 4-kinase
2jul	NMR Structure of DREAM
2jww	Calcium-free rat alpha-parvalbumin
2jxl	Solution structure of cardiac N-domain troponin C mutant F77W-V82A
2jzi	Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin
2k0e	A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction
2k0f	Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase
2k0j	Solution structure of CaM complexed to DRP1p
2k2a	Solution Structure of the Apo C terminal domain of Lethocerus troponin C isoform F1
2k2i	NMR Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a repeat sequence of human Sfi1 (R641-T660)
2k3s	HADDOCK-derived structure of the CH-domain of the smoothelin-like 1 complexed with the C-domain of apocalmodulin
2k61	Solution structure of CaM complexed to DAPk peptide
2k7c	NMR Structure of Mg2+-bound CaBP1 C-domain
2k7d	NMR Structure of Ca2+-bound CaBP1 C-domain
2kdh	The Solution Structure of Human Cardiac Troponin C in complex with the Green Tea Polyphenol; (-)-epigallocatechin-3-gallate
2kdu	Structural basis of the Munc13-1/Ca2+-Calmodulin interaction: A novel 1-26 calmodulin binding motif with a bipartite binding mode
2kfx	Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7
2kgb	NMR solution of the regulatory domain cardiac F77W-Troponin C in complex with the cardiac Troponin I 144-163 switch peptide
2kn2	Solution structure of the C-terminal domain of soybean calmodulin isoform 4 fused with the calmodulin-binding domain of NtMKP1
2kne	Calmodulin wraps around its binding domain in the plasma membrane CA2+ pump anchored by a novel 18-1 motif
2kqy	Solution structure of Avian Thymic Hormone
2krd	Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of cardiac Troponin I and W7
2ksz	The solution structure of the Magnesium bound soybean calmodulin isoform 4 N-domain
2kug	Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM N-terminal domain
2kuh	Halothane binds to druggable sites in calcium-calmodulin: Solution structure of halothane-CaM C-terminal domain
2kxw	Structure of the C-domain Fragment of apo Calmodulin Bound to the IQ motif of Nav1.2
2kyc	solution structure of Ca-free chicken parvalbumin 3 (CPV3)
2kyf	solution structure of calcium-bound CPV3
2kz2	Calmodulin, C-terminal domain, F92E mutant
2l1r	The structure of the calcium-sensitizer, dfbp-o, in complex with the N-domain of troponin C and the switch region of troponin I
2l1w	The solution structure of soybean calmodulin isoform 4 complexed with the vacuolar calcium ATPase BCA1 peptide
2l2e	Solution NMR structure of myristoylated NCS1p in apo form
2l4h	The Solution Structure of Calcium Bound CIB1
2l4i	The Solution Structure of Magnesium bound CIB1
2l53	Solution NMR Structure of apo-calmodulin in complex with the IQ motif of Human Cardiac Sodium Channel NaV1.5
2l7l	Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I
2l98	Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C
2lan	NMR structure of Ca2+-bound CaBP1 N-domain with RDC
2lap	NMR structure of Ca2+-bound CaBP1 C-domain with RDC
2lc5	Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein
2lcp	NMR structure of calcium loaded, un-myristoylated human NCS-1
2lgf	Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin
2lhh	Solution structure of Ca2+-bound yCaM
2lhi	Solution structure of Ca2+/CNA1 peptide-bound yCaM
2ll6	Solution NMR structure of CaM bound to iNOS CaM binding domain peptide
2ll7	Solution NMR structure of CaM bound to the eNOS CaM binding domain peptide
2llo	Solution NMR-derived structure of calmodulin N-lobe bound with ER alpha peptide
2llq	Solution nmr-derived structure of calmodulin c-lobe bound with er alpha peptide
2lm5	Solution structure of Ca2+-CIB1 in complex with the cytoplasmic domain of the integrin aIIb subunit
2lmt	NMR structure of Androcam
2lmu	Androcam at high calcium
2lmv	Androcam at high calcium with three explicit Ca2+
2lqc	NMR solution structure of a Ca2+-Calmodulin with a binding motif (NSCaTE) peptide from the N-terminal cytoplasmic domain of the L-type Voltage-Cated Calcium Channel alpha1C subunit
2lqp	NMR solution structure of the Ca2+-Calmodulin C-terminal domain in a complex with a peptide (NSCaTE) from the L-type Voltage-Gated Calcium Channel alpha1C subunit
2lv6	The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data
2lv7	Solution structure of Ca2+-bound CaBP7 N-terminal doman
2lvi	Solution structure of apo-Phl p 7
2lvj	solution structure of hemi-Mg-bound Phl p 7
2lvk	Solution structure of Ca-bound Phl p 7
2lvv	NMR structure of TB24
2m0j	3D Structure of Calmodulin and Calmodulin binding domain of Olfactory cyclic nucleotide-gated ion channel complex
2m0k	3D Structure of Calmodulin and Calmodulin Binding Domain of Rat Olfactory Cyclic Nucleotide-Gated Ion Channel
2m1u	Solution structure of the small dictyostelium discoideium myosin light chain mlcb provides insights into iq-motif recognition of class i myosin myo1b
2m28	NMR structure of Ca2+ bound CaBP4 C-domain
2m29	NMR structure of Ca2+ bound CaBP4 N-domain
2m3s	Calmodulin, i85l, f92e, h107i, l107i, a128t, m144r mutant
2m55	NMR structure of the complex of an N-terminally acetylated alpha-synuclein peptide with calmodulin
2m5e	2M5E
2m7k	NMR solution structure of N-terminal domain of (Y81F)-EhCaBP1
2m7m	N-terminal domain of EhCaBP1 structure
2m7n	C-terminal structure of (Y81F)-EhCaBP1
2m8u	2M8U
2m97	Optimized Ratiometric Calcium Sensors For Functional In Vivo Imaging of Neurons and T-Lymphocytes
2ma2	Solution structure of RasGRP2 EF hands bound to calcium
2mbx	2MBX
2mes	2MES
2mg5	Solution Structure of Calmodulin bound to the target peptide of Endothelial Nitrogen Oxide Synthase phosphorylated at Thr495
2mgu	Structure of the complex between calmodulin and the binding domain of HIV-1 matrix protein
2mhh	2MHH
2mkp	N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I at pH 6
2mle	NMR structure of the C-domain of troponin C bound to the anchoring region of troponin I
2mlf	NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring region of troponin I
2mys	MYOSIN SUBFRAGMENT-1, ALPHA CARBON COORDINATES ONLY FOR THE TWO LIGHT CHAINS
2mzp	2MZP
2n27	2N27
2n6a	2N6A
2n77	2N77
2n79	2N79
2n7l	2N7L
2n8j	2N8J
2n8y	2N8Y
2n8z	2N8Z
2na0	2NA0
2nco	2NCO
2ncp	2NCP
2nln	Solution Structure of Calcium-free Rat Beta-parvalbumin
2nxq	Crystal structure of calcium binding protein 1 from Entamoeba histolytica: a novel arrangement of EF hand motifs
2nz0	Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)
2o5g	Calmodulin-smooth muscle light chain kinase peptide complex
2o60	Calmodulin bound to peptide from neuronal nitric oxide synthase
2obh	Centrin-XPC peptide
2opo	Crystal structure of the calcium-binding pollen allergen Che a 3
2os8	Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor
2otg	Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor
2p6b	Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide
2pal	IONIC INTERACTIONS WITH PARVALBUMINS. CRYSTAL STRUCTURE DETERMINATION OF PIKE 4.10 PARVALBUMIN IN FOUR DIFFERENT IONIC ENVIRONMENTS
2pas	COMPARISON BETWEEN THE CRYSTAL AND THE SOLUTION STRUCTURES OF THE EF HAND PARVALBUMIN
2pmy	EF-hand domain of human RASEF
2pq3	N-Terminal Calmodulin Zn-Trapped Intermediate
2pvb	PIKE PARVALBUMIN (PI 4.10) AT LOW TEMPERATURE (100K) AND ATOMIC RESOLUTION (0.91 A).
2q4u	Ensemble refinement of the crystal structure of an EF-hand protein from Danio rerio Dr.36843
2r28	The complex Structure of Calmodulin Bound to a Calcineurin Peptide
2r2i	Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound
2ro8	Solution structure of calcium bound soybean calmodulin isoform 1 N-terminal domain
2ro9	Solution structure of calcium bound soybean calmodulin isoform 1 C-terminal domain
2roa	Solution structure of calcium bound soybean calmodulin isoform 4 N-terminal domain
2rob	Solution structure of calcium bound soybean calmodulin isoform 4 C-terminal domain
2rrt	Solution structure of Magnesium-bound form of calmodulin C-domain E104D/E140D mutant
2sas	STRUCTURE OF A SARCOPLASMIC CALCIUM-BINDING PROTEIN FROM AMPHIOXUS REFINED AT 2.4 ANGSTROMS RESOLUTION
2scp	STRUCTURE OF A SARCOPLASMIC CALCIUM-BINDING PROTEIN FROM NEREIS DIVERSICOLOR REFINED AT 2.0 ANGSTROMS RESOLUTION
2tn4	FOUR CALCIUM TNC
2v01	Recombinant vertebrate calmodulin complexed with Pb
2v02	Recombinant vertebrate calmodulin complexed with Ba
2vas	Myosin VI (MD-insert2-CaM, Delta-Insert1) Post-rigor state
2vay	Calmodulin complexed with CaV1.1 IQ peptide
2vb6	Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)
2w49	Isometrically contracting insect asynchronous flight muscle
2w4a	Isometrically contracting insect asynchronous flight muscle
2w4g	Isometrically contracting insect asynchronous flight muscle quick frozen after a quick stretch step
2w4h	Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step
2w4t	Isometrically contracting insect asynchronous flight muscle
2w4u	Isometrically contracting insect asynchronous flight muscle quick frozen after a length step
2w4v	Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step
2w4w	Isometrically contracting insect asynchronous flight muscle quick frozen after a quick stretch step
2w73	High-resolution structure of the complex between calmodulin and a peptide from calcineurin A
2wel	Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin
2x0g	X-RAY STRUCTURE OF A DAP-KINASE CALMODULIN COMPLEX
2x51	M6 delta Insert1
2y4v	CRYSTAL STRUCTURE OF HUMAN CALMODULIN IN COMPLEX WITH A DAP KINASE-1 MUTANT (W305Y) PEPTIDE
2ygg	Complex of CaMBR and CaM
2zfd	The crystal structure of plant specific calcium binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14
2zn8	Crystal structure of Zn2+-bound form of ALG-2
2zn9	Crystal structure of Ca2+-bound form of des3-20ALG-2
2znd	Crystal structure of Ca2+-free form of des3-20ALG-2
2zne	Crystal structure of Zn2+-bound form of des3-23ALG-2 complexed with Alix ABS peptide
2zrs	Crystal structure of Ca2+-bound form of des3-23ALG-2
2zrt	Crystal structure of Zn2+-bound form of des3-23ALG-2
3a8r	The structure of the N-terminal regulatory domain of a plant NADPH oxidase
3aaj	Crystal structure of Ca2+-bound form of des3-23ALG-2deltaGF122
3aak	Crystal structure of Zn2+-bound form of des3-20ALG-2F122A
3aka	Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium-binding protein
3akb	Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium-binding protein
3b32	Crystal Structure of Calcium-Saturated Calmodulin N-Terminal Domain Fragment, Residues 1-75
3bow	Structure of M-calpain in complex with Calpastatin
3bxk	Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex
3bxl	Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex
3bya	Structure of a Calmodulin Complex
3cln	STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION
3cs1	Flagellar Calcium-binding Protein (FCaBP) from T. cruzi
3ctn	STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES
3dd4	Structural Basis of KChIP4a Modulation of Kv4.3 Slow Inactivation
3df0	Calcium-dependent complex between m-calpain and calpastatin
3dtp	Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick filament Cryo-EM 3D-MAP
3dve	Crystal Structure of Ca2+/CaM-CaV2.2 IQ domain complex
3dvj	Crystal Structure of Ca2+/CaM-CaV2.2 IQ domain (without cloning artifact, HM to TV) complex
3dvk	Crystal Structure of Ca2+/CaM-CaV2.3 IQ domain complex
3dvm	Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex
3e3r	Crystal structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family
3ek4	Calcium-saturated GCaMP2 Monomer
3ek7	Calcium-saturated GCaMP2 dimer
3ek8	Calcium-saturated GCaMP2 T116V/G87R mutant monomer
3ekh	Calcium-saturated GCaMP2 T116V/K378W mutant monomer
3ekj	Calcium-free GCaMP2 (calcium binding deficient mutant)
3evr	Crystal structure of Calcium bound monomeric GCAMP2
3evu	Crystal structure of Calcium bound dimeric GCAMP2, (#1)
3evv	Crystal Structure of Calcium bound dimeric GCAMP2 (#2)
3ewt	Crystal Structure of calmodulin complexed with a peptide
3ewv	Crystal Structure of calmodulin complexed with a peptide
3f45	Structure of the R75A mutant of rat alpha-Parvalbumin
3fs7	Crystal structure of Gallus gallus beta-parvalbumin (avian thymic hormone)
3fwb	Sac3:Sus1:Cdc31 complex
3fwc	Sac3:Sus1:Cdc31 complex
3g43	Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer
3gn4	Myosin lever arm
3gof	Calmodulin bound to peptide from macrophage nitric oxide synthase
3gp2	Calmodulin bound to peptide from calmodulin kinase II (CaMKII)
3hr4	Human iNOS Reductase and Calmodulin Complex
3hx4	Crystal structure of CDPK1 of Toxoplasma gondii, TGME49_101440, in presence of calcium
3hzt	Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860
3i5f	Crystal structure of squid MG.ADP myosin S1
3i5g	Crystal structure of rigor-like squid myosin S1
3i5h	The crystal structure of rigor like squid myosin S1 in the absence of nucleotide
3i5i	The crystal structure of squid myosin S1 in the presence of SO4 2-
3i79	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1)
3i7b	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NM-PP1
3i7c	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NA-PP2
3if7	Structure of Calmodulin complexed with its first endogenous inhibitor, sphingosylphosphorylcholine
3ifk	Crystal Structure Of Calcium-Saturated Calmodulin N-terminal Domain Fragment, Residues 1-90
3igo	Crystal structure of Cryptosporidium parvum CDPK1, cgd3_920
3j04	EM structure of the heavy meromyosin subfragment of Chick smooth muscle Myosin with regulatory light chain in phosphorylated state
3j41	Pseudo-atomic model of the Aquaporin-0/Calmodulin complex derived from electron microscopy
3jax	3JAX
3jbh	3JBH
3jtd	Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation
3jvt	Calcium-bound Scallop Myosin Regulatory Domain (Lever Arm) with Reconstituted Complete Light Chains
3k21	Crystal Structure of carboxy-terminus of PFC0420w.
3kf9	Crystal structure of the SdCen/skMLCK complex
3khe	Crystal structure of the calcium-loaded calmodulin-like domain of the CDPK, 541.m00134 from toxoplasma gondii
3kpx	Crystal Structure Analysis of photoprotein clytin
3ku2	Crystal Structure of inactivated form of CDPK1 from toxoplasma gondii, TGME49.101440
3l19	Crystal structure of calcium binding domain of CpCDPK3, cgd5_820
3l9i	Myosin VI nucleotide-free (mdinsert2) L310G mutant crystal structure
3li6	Crystal structure and trimer-monomer transition of N-terminal domain of EhCaBP1 from Entamoeba histolytica
3lij	Crystal structure of full length CpCDPK3 (cgd5_820) in complex with Ca2+ and AMPPNP
3ll8	Crystal Structure of Calcineurin in Complex with AKAP79 Peptide
3mse	Crystal structure of C-terminal domain of PF110239.
3mwu	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95
3n51	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor RM-1-95
3ncg	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor NM-PP1
3nyv	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with non-specific inhibitor WHI-P180
3o4y	Crystal structure of CAD domain of the Plasmodium Vivax CDPK, PVX_11610
3o77	The structure of Ca2+ Sensor (Case-16)
3o78	The structure of Ca2+ Sensor (Case-12)
3ox5	Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)
3ox6	Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)
3oxq	Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex
3pal	IONIC INTERACTIONS WITH PARVALBUMINS. CRYSTAL STRUCTURE DETERMINATION OF PIKE 4.10 PARVALBUMIN IN FOUR DIFFERENT IONIC ENVIRONMENTS
3pat	COMPARISON BETWEEN THE CRYSTAL AND THE SOLUTION STRUCTURES OF THE EF HAND PARVALBUMIN
3pm8	CAD domain of PFF0520w, Calcium dependent protein kinase
3pn7	Visualizing new hinges and a potential major source of compliance in the lever arm of myosin
3px1	Structure of Calcium Binding Protein-1 from Entamoeba histolytica in complex with Strontium
3q5i	Crystal Structure of PBANKA_031420
3qjk	Structure of Calcium Binding Protein-1 from Entamoeba histolytica in complex with Lead
3qrx	Chlamydomonas reinhardtii centrin bound to melittin
3rv5	Crystal structure of human cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid
3sd6	Crystal structure of the amino-terminal domain of human cardiac troponin C in complex with cadmium at 1.4 resolution.
3sg2	Crystal Structure of GCaMP2-T116V,D381Y
3sg3	Crystal Structure of GCaMP3-D380Y
3sg4	Crystal Structure of GCaMP3-D380Y, LP(linker 2)
3sg5	Crystal Structure of Dimeric GCaMP3-D380Y, QP(linker 1), LP(linker 2)
3sg6	Crystal Structure of Dimeric GCaMP2-LIA(linker 1)
3sg7	Crystal Structure of GCaMP3-KF(linker 1)
3sia	Crystal structure of URE3-binding protein, (D127A,N129A) mutant, iodide phased
3sib	Crystal structure of URE3-binding protein, wild-type
3sjq	Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin
3sjs	Crystal structure of URE3-binding protein from Entamoeba histolytica, (D127A,N129A) mutant, native form
3sui	Crystal structure of ca2+-calmodulin in complex with a trpv1 c-terminal peptide
3swb	Crystal structure of the amino-terminal domain of human cardiac troponin C in complex with cadmium at 1.7 A resolution
3sx9	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-132
3sxf	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-89
3t3u	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-130
3t3v	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-87
3ts5	Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin
3tuy	Phosphorylated Light Chain Domain of Scallop smooth Muscle Myosin
3tz1	Crystal structure of the Ca2+-saturated C-terminal domain of Akazara scallop troponin C in complex with a troponin I fragment
3u0k	Crystal Structure of the genetically encoded calcium indicator RCaMP
3uct	Structure of Mn2+-bound N-terminal domain of calmodulin in the presence of Zn2+
3ucw	Structure of MG2+ bound N-Terminal domain of Calmodulin
3ucy	Structure of Mg2+ bound N-terminal domain of calmodulin in the presence of Zn2+
3ulg	Crystal structure of Calcium-Binding Protein-1 from Entamoeba histolytica in complex with barium
3upx	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300
3upz	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243
3v51	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor RM-1-176
3v5p	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1288
3v5t	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1299
3wfn	Crystal Structure of Nav1.6 IQ motif in complex with apo-CaM
3wlc	Crystal structure of dimeric GCaMP6m
3wld	Crystal structure of monomeric GCaMP6m
3wxa	3WXA
4anj	MYOSIN VI (MDinsert2-GFP fusion) PRE-POWERSTROKE STATE (MG.ADP.AlF4)
4aqr	Crystal structure of calmodulin in complex with the regulatory domain of a plasma-membrane Ca2+-ATPase
4bw7	Calmodulin in complex with strontium
4bw8	Calmodulin with small bend in central helix
4by4	4BY4
4by5	4BY5
4bya	4BYA
4byf	Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke state
4c0j	Crystal structure of Drosophila Miro EF hand and cGTPase domains in the apo state (Apo-MiroS)
4c0k	Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one calcium ion (Ca-MiroS)
4c0l	Crystal structure of Drosophila Miro EF hand and cGTPase domains bound to one magnesium ion and Mg:GDP (MgGDP-MiroS)
4cln	STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTION
4cpv	REFINED CRYSTAL STRUCTURE OF CALCIUM-LIGANDED CARP PARVALBUMIN 4.25 AT 1.5-ANGSTROMS RESOLUTION
4d1e	4D1E
4dbp	Myosin VI nucleotide-free (MDINSERT2) D179Y crystal structure
4dbq	MYOSIN VI D179Y (MD-INSERT2-CAM, DELTA-INSERT1) post-rigor state
4dck	Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM
4djc	1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
4ds7	Crystal structure of yeast calmodulin bound to the C-terminal fragment of spindle pole body protein Spc110
4e50	Calmodulin and Ng peptide complex
4e53	Calmodulin and Nm peptide complex
4ehq	Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode
4f0z	Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L
4g27	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea
4g28	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and EBIO-1
4gje	Crystal structure of the refolded amino-terminal domain of human cardiac troponin C in complex with cadmium
4gjf	Crystal structure of the amino-terminal domain of human cardiac troponin C mutant L29Q in complex with cadmium
4gjg	Crystal structure of the amino-terminal domain of human cardiac troponin C mutant D2N/V28I/L29Q/G30D (NIQD) in complex with cadmium.
4gow	Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex
4guk	New crystal form structure of human NCS1
4hex	A novel conformation of calmodulin
4i2y	Crystal Structure of the genetically encoded calcium indicator RGECO1
4ieb	Crystal Structure of a Gly128Met mutant of the toxoplasma CDPK, TGME49_101440
4ifg	Crystal structure of TgCDPK1 with inhibitor bound
4ih8	Crystal structure of TgCDPK1 with inhibitor bound
4ihp	Crystal structure of TgCDPK1 with inhibitor bound
4ik1	High resolution structure of GCaMPJ at pH 8.5
4ik3	High resolution structure of GCaMP3 at pH 8.5
4ik4	High resolution structure of GCaMP3 at pH 5.0
4ik5	High resolution structure of Delta-REST-GCaMP3
4ik8	High resolution structure of GCaMP3 dimer form 1 at pH 7.5
4ik9	High resolution structure of GCaMP3 dimer form 2 at pH 7.5
4il1	Crystal Structure of the Rat Calcineurin
4j9y	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant
4j9z	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309
4jbv	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268
4jpz	Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin
4jq0	Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin
4jwq	Crystal Structure of the Calcium Binding Domain of CDPK3 from Plasmodium Berghei, PB000947.00
4l79	Crystal Structure of nucleotide-free Myosin 1b residues 1-728 with bound Calmodulin
4lzx	Complex of IQCG and Ca2+-free CaM
4m1l	Complex of IQCG and Ca2+-bound CaM
4m2o	Crystal structure of a non-myristoylated C39A recoverin mutant with one calcium ion bound to EF-hand 3
4m2p	Crystal structure of a non-myristoylated C39D recoverin mutant with one calcium ion bound to EF-hand 3
4m2q	Crystal structure of non-myristoylated recoverin with Cysteine-39 oxidized to sulfenic acid
4m84	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1455
4m97	Calcium-Dependent Protein Kinase 1 from Neospora caninum
4mbe	4MBE
4mlw	Crystal structure of non-myristoylated recoverin at 1.45 A resolution with calcium bound to EF-hand 3
4mn0	Spatial structure of the novel light-sensitive photoprotein berovin from the ctenophore Beroe abyssicola in the Ca2+-loaded apoprotein conformation state
4mrx	Crystal Structure of Y138F obelin mutant from Obelia longissima at 1.72 Angstrom resolution
4mry	Crystal Structure of Ca(2+)- discharged Y138F obelin mutant from Obelia longissima at 1.30 Angstrom resolution
4msp	Crystal structure of human peptidyl-prolyl cis-trans isomerase FKBP22 (aka FKBP14) containing two EF-hand motifs
4mvf	4MVF
4mx9	CDPK1 from Neospora caninum in complex with inhibitor UW1294
4mxa	CDPK1 from Neospora caninum in complex with inhibitor RM-1-132
4n1f	Crystal Structure of F88Y obelin mutant from Obelia longissima at 2.09 Angstrom resolution
4n1g	Crystal Structure of Ca(2+)- discharged F88Y obelin mutant from Obelia longissima at 1.50 Angstrom resolution
4n5x	Crystal structure of N-terminal calmodulin-like Calcium sensor of human mitochondrial ATP-Mg/Pi carrier SCaMC1
4ndb	4NDB
4ndc	4NDC
4ndd	4NDD
4nqg	4NQG
4nsc	Crystal Structure of CBARA1 in the Apo-form
4nsd	Crystal Structure of CBARA1 in the Ca2+ Binding Form
4oci	4OCI
4okh	4OKH
4ona	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
4or9	4OR9
4ora	4ORA
4orb	4ORB
4orc	4ORC
4ov2	Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus
4ovn	4OVN
4oy4	4OY4
4p5w	4P5W
4p5x	4P5X
4p60	4P60
4pal	IONIC INTERACTIONS WITH PARVALBUMINS. CRYSTAL STRUCTURE DETERMINATION OF PIKE 4.10 PARVALBUMIN IN FOUR DIFFERENT IONIC ENVIRONMENTS
4phj	4PHJ
4phk	4PHK
4phm	4PHM
4phn	4PHN
4pjj	4PJJ
4q04	Crystal structure of URE3-BP from Entomaeba histolytica without calcium
4q57	4Q57
4q5u	4Q5U
4qnh	4QNH
4qox	4QOX
4r8g	4R8G
4rgj	4RGJ
4rjd	4RJD
4tnc	REFINED STRUCTURE OF CHICKEN SKELETAL MUSCLE TROPONIN C IN THE TWO-CALCIUM STATE AT 2-ANGSTROMS RESOLUTION
4tzr	4TZR
4u8d	4U8D
4umo	4UMO
4upg	4UPG
4upu	4UPU
4usl	4USL
4v0c	4V0C
4wg3	4WG3
4wg4	4WG4
4wg5	4WG5
4wpx	4WPX
4wq2	4WQ2
4wq3	4WQ3
4y5q	4Y5Q
4y99	4Y99
4yga	4YGA
4yi8	4YI8
4yi9	4YI9
4yjn	4YJN
4yru	4YRU
4ysj	4YSJ
4ysm	4YSM
4yuq	4YUQ
4yzb	4YZB
4zcu	4ZCU
4zcv	4ZCV
4zlk	4ZLK
5a2h	5A2H
5aeq	5AEQ
5aer	5AER
5afp	5AFP
5b8i	5B8I
5bpj	5BPJ
5coc	5COC
5cpv	RESTRAINED LEAST SQUARES REFINEMENT OF NATIVE (CALCIUM) AND CADMIUM-SUBSTITUTED CARP PARVALBUMIN USING X-RAY CRYSTALLOGRAPHIC DATA AT 1.6-ANGSTROMS RESOLUTION
5d43	5D43
5d69	5D69
5dow	5DOW
5dqq	5DQQ
5dvr	5DVR
5e1j	5E1J
5e1k	5E1K
5e1n	5E1N
5e1p	5E1P
5e37	5E37
5f6t	5F6T
5ggm	5GGM
5go9	5GO9
5goa	5GOA
5gqq	5GQQ
5hit	5HIT
5i0i	5I0I
5ibw	5IBW
5j03	5J03
5j8h	5J8H
5jjg	5JJG
5jms	5JMS
5jn2	5JN2
5k7l	5K7L
5k8q	5K8Q
5ksz	5KSZ
5kty	5KTY
5ku1	5KU1
5pal	CRYSTAL STRUCTURE OF THE UNIQUE PARVALBUMIN COMPONENT FROM MUSCLE OF THE LEOPARD SHARK (TRIAKIS SEMIFASCIATA). THE FIRST X-RAY STUDY OF AN ALPHA-PARVALBUMIN
5sy1	5SY1
5t6a	5T6A
5t6i	5T6I
5t6k	5T6K
5tnc	REFINED CRYSTAL STRUCTURE OF TROPONIN C FROM TURKEY SKELETAL MUSCLE AT 2.0 ANGSTROMS RESOLUTION

Links (links to other resources describing this domain)

• INTERPRO: IPR002048
• PFAM: efhand