The domain within your query sequence starts at position 1116 and ends at position 1149; the E-value for the EGF domain shown below is 1.62e-5.

EFSPPMVLPRTSPCDNFDCQNGAQCIIRINEPIC

EGF

Epidermal growth factor-like domain.

• SMART accession number: SM00181
• Description: -
• Interpro abstract (IPR000742):

  A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [ (PUBMED:2288911) (PUBMED:6334307) (PUBMED:6607417) (PUBMED:3282918) ] to be present, in a more or less conserved form, in a large number of other, mostly animal proteins. EGF is a polypeptide of about 50 amino acids with three internal disulfide bridges. It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation.

  A common feature of all EGF-like domains is that they are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF-like domain includes six cysteine residues which have been shown to be involved in disulfide bonds. The structure of several EGF-like domains has been solved. The fold consists of two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.

There are 539475 EGF domains in 145300 proteins in SMART's nrdb database.

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Rao Z, Handford P, Mayhew M, Knott V, Brownlee GG, Stuart D
• The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.
• Cell. 1995; 82: 131-41

Various diverse extracellular proteins possess Ca(2+)-binding epidermal growth factor (EGF)-like domains, the function of which remains uncertain. We have determined, at high resolution (1.5 A), the crystal structure of such a domain, from human clotting factor IX, as a complex with Ca2+. The Ca2+ ligands form a classic pentagonal bipyramid with six ligands contributed by one polypeptide chain and the seventh supplied by a neighboring EGF-like domain. The crystal structure identifies the role of Ca2+ in maintaining the conformation of the N-terminal region of the domain, but more importantly demonstrates that Ca2+ can directly mediate protein-protein contacts. The observed crystal packing of the domains provides a plausible model for the association of multiple tandemly linked EGF-like domains in proteins such as fibrillin-1, Notch, and protein S. This model is consistent with the known functional data and suggests a general biological role for these domains.

• Holmes WE et al.
• Identification of heregulin, a specific activator of p185erbB2.
• Science. 1992; 256: 1205-10

The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the epidermal growth factor family. Scatchard analysis of the binding of recombinant HRG to a breast tumor cell line expressing p185erbB2 showed a single high affinity binding site [dissociation constant (Kd) = 105 +/- 15 picomolar]. Heregulin transcripts were identified in several normal tissues and cancer cell lines. The HRGs may represent the natural ligands for p185erbB2.

• Engel J
• EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation?
• FEBS Lett. 1989; 251: 1-7

Multidomain proteins of the extracellular matrix (ECM) play an important role in development and maintenance of cellular organization and in tissue repair. Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. The mitogenic activity of laminin is restricted to a fragment which consists of about 25 repeating domains with partial homology to EGF and comprises the rod-like inner regions of the three short arms of the four armed molecule. The mitogenic activity does not correlate with promotion of cell attachment and neurite outgrowth for which major functional sites have been found in other regions of the laminin molecule. It is suggested that EGF-like domains in laminin, in other ECM proteins and in the extracellular portions of some membrane proteins are signals for cellular growth and differentiation. Because they are integral parts of large molecules and often of supramolecular assemblies these domains are well suited to stimulate neighboring cells in a specific and vectorial way. This concept of localized growth or differentiation signals offers an attractive mechanism for the regulation of cellular development.

• Appella E, Weber IT, Blasi F
• Structure and function of epidermal growth factor-like regions in proteins.
• FEBS Lett. 1988; 231: 1-4

• Doolittle RF, Feng DF, Johnson MS
• Computer-based characterization of epidermal growth factor precursor.
• Nature. 1984; 307: 558-60

The cDNA sequence of the precursor of mouse epidermal growth factor (EGFP) has recently been reported by two groups, both of whom noted the presence of repeated similar segments, each about 40 residues long. One of these repeat units overlaps with the sequence of epidermal growth factor itself. The sequence of epidermal growth factor has been reported to be similar to that of pancreatic secretory trypsin inhibitor (PSTI) and a somewhat better match has been found with part of the sequence of bovine factor X, one of the blood coagulating factors. We report here that there is an even stronger similarity between the sequences of some of the repeat units of epidermal growth factor precursor and certain segments in factor X. This sequence similarity is also apparent in comparisons with other blood coagulation factors. On the basis of these sequence comparisons we suggest a scheme for the evolution of the epidermal growth factor precursor. We have also identified certain structural features in the precursor sequence that bear on the way in which the mature epidermal growth factor is generated.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the EGF domain.

Protein	Disease
EGF-containing fibulin-like extracellular matrix protein 1 (Q12805) (SMART)	OMIM:601548: Doyne honeycomb degeneration of retina OMIM:126600: OMIM:126600: Doyne honeycomb retinal dystrophy
Vitamin K-dependent protein C (P04070) (SMART)	OMIM:176860: Thrombophilia due to protein C deficiency ; Purpura fulminans, neonatal
Thyroid peroxidase (P07202) (SMART)	OMIM:274500: Thyroid iodine peroxidase deficiency ; Goiter, congenital ; Hypothyroidism, congenital
Low-density lipoprotein receptor (P01130) (SMART)	OMIM:143890: Hypercholesterolemia, familial
Coagulation factor IX (P00740) (SMART)	OMIM:306900: Hemophilia B ; Warfarin sensitivity
Fibrillin-1 (P35555) (SMART)	OMIM:134797: Marfan syndrome OMIM:154700: Shprintzen-Goldberg syndrome OMIM:182212: Ectopia lentis, familial ; MASS syndrome OMIM:604308:
Coagulation factor VII (P08709) (SMART)	OMIM:227500: Factor VII deficiency ; {Myocardial infarction, decreased susceptibility to}
Delta-like protein 3 (Q9NYJ7) (SMART)	OMIM:602768: Spondylocostal dysostosis, autosomal recessive, 1 OMIM:277300:
Fibrillin-2 (P35556) (SMART)	OMIM:121050: Contractural arachnodactyly, congenital
Vitamin K-dependent protein S (P07225) (SMART)	OMIM:176880: Protein S deficiency

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
10.89	map04512	ECM-receptor interaction
10.51	map04510	Focal adhesion
9.08	map04610	Complement and coagulation cascades
9.08	map04330	Notch signaling pathway
8.17	map04012	ErbB signaling pathway
7.00	map04514	Cell adhesion molecules (CAMs)
4.02	map04350	TGF-beta signaling pathway
3.63	map04320	Dorso-ventral axis formation
3.37	map04810	Regulation of actin cytoskeleton
3.24	map04360	Axon guidance
2.85	map04310	Wnt signaling pathway
2.20	map04340	Hedgehog signaling pathway
2.08	map00590	Arachidonic acid metabolism
1.95	map00531	Glycosaminoglycan degradation
1.95	map01032	Glycan structures - degradation
1.82	map05212	Pancreatic cancer
1.82	map05214	Glioma
1.82	map05223	Non-small cell lung cancer
1.82	map05215	Prostate cancer
1.30	map04060	Cytokine-cytokine receptor interaction
1.17	map05217	Basal cell carcinoma
1.04	map05219	Bladder cancer
1.04	map05120	Epithelial cell signaling in Helicobacter pylori infection
1.04	map05213	Endometrial cancer
1.04	map04010	MAPK signaling pathway
1.04	map04912	GnRH signaling pathway
1.04	map04540	Gap junction
1.04	map05218	Melanoma
0.78	map05010	Alzheimer's disease
0.78	map05211	Renal cell carcinoma
0.52	map05222	Small cell lung cancer
0.26	map04670	Leukocyte transendothelial migration
0.13	map00350	Tyrosine metabolism
0.13	map04140	Regulation of autophagy
0.13	map04640	Hematopoietic cell lineage
0.13	map00562	Inositol phosphate metabolism
0.13	map04070	Phosphatidylinositol signaling system

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EGF domain which could be assigned to a KEGG orthologous group, and not all proteins containing EGF domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of EGF domains in PDB

PDB code	Title
1a3p	ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES
1adx	FIFTH EGF-LIKE DOMAIN OF THROMBOMODULIN (TMEGF5), NMR, 14 STRUCTURES
1cqe	PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN
1cvu	CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
1cvw	Crystal structure of active site-inhibited human coagulation factor VIIA (DES-GLA)
1cx2	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558
1ddx	CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE
1diy	CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1
1dqb	NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)
1dx5	Crystal structure of the thrombin-thrombomodulin complex
1ebv	OVINE PGHS-1 COMPLEXED WITH SALICYL HYDROXAMIC ACID
1egf	SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS
1epg	THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
1eph	THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
1epi	THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
1epj	THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS
1eqg	THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN
1eqh	THE 2.7 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH FLURBIPROFEN
1esl	INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS
1fe2	CRYSTAL STRUCTURE OF DIHOMO-GAMMA-LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.
1fjs	CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA
1fsb	STRUCTURE OF THE EGF DOMAIN OF P-SELECTIN, NMR, 19 STRUCTURES
1g1q	Crystal structure of P-selectin lectin/EGF domains
1g1r	Crystal structure of P-selectin lectin/EGF domains complexed with SLeX
1g1s	P-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH PSGL-1 PEPTIDE
1g1t	CRYSTAL STRUCTURE OF E-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH SLEX
1gk5	Solution Structure the mEGF/TGFalpha44-50 chimeric growth factor
1gl4	Nidogen-1 G2/Perlecan IG3 Complex
1hae	HEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, 20 STRUCTURES
1haf	HEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
1hcg	STRUCTURE OF HUMAN DES(1-45) FACTOR XA AT 2.2 ANGSTROMS RESOLUTION
1hre	SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4
1hrf	SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4
1ht5	THE 2.75 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH METHYL ESTER FLURBIPROFEN
1ht8	THE 2.7 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH ALCLOFENAC
1igx	Crystal Structure of Eicosapentanoic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.
1igz	Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.
1ijq	Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair
1iox	NMR Structure of human Betacellulin-2
1ip0	NMR STRUCTURE OF HUMAN BETACELLULIN-2
1ivo	Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
1j9c	Crystal Structure of tissue factor-factor VIIa complex
1jbu	Coagulation Factor VII Zymogen (EGF2/Protease) in Complex with Inhibitory Exosite Peptide A-183
1jl9	Crystal Structure of Human Epidermal Growth Factor
1k36	NMR Structure of human Epiregulin
1k37	NMR Structure of human Epiregulin
1kig	BOVINE FACTOR XA
1kli	Cofactor-and substrate-assisted activation of factor VIIa
1klj	Crystal structure of uninhibited factor VIIa
1mox	Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha
1mq5	Crystal Structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa
1mq6	Crystal Structure of 3-chloro-N-[4-chloro-2-[[(5-chloro-2-pyridinyl)amino]carbonyl]-6-methoxyphenyl]-4-[[(4,5-dihydro-2-oxazolyl)methylamino]methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa
1nql	Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.
1p9j	Solution structure and dynamics of the EGF/TGF-alpha chimera T1E
1pge	PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH P-(2'-IODO-5'-THENOYL)HYDROTROPIC ACID (IODOSUPROFEN)
1pgf	PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL
1pgg	PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), TRANS MODEL
1prh	THE X-RAY CRYSTAL STRUCTURE OF THE MEMBRANE PROTEIN PROSTAGLANDIN H2 SYNTHASE-1
1pth	THE STRUCTURAL BASIS OF ASPIRIN ACTIVITY INFERRED FROM THE CRYSTAL STRUCTURE OF INACTIVATED PROSTAGLANDIN H2 SYNTHASE
1pxx	CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
1q4g	2.0 Angstrom Crystal Structure of Ovine Prostaglandin H2 Synthase-1, in complex with alpha-methyl-4-biphenylacetic acid
1qfk	STRUCTURE OF HUMAN FACTOR VIIA AND ITS IMPLICATIONS FOR THE TRIGGERING OF BLOOD COAGULATION
1rfn	HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE
1tpg	F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)
1u67	Crystal Structure of Arachidonic Acid Bound to a Mutant of Prostagladin H Synthase-1 that Forms Predominantly 11-HPETE.
1v3x	Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine
1w7x	Factor7 - 413 complex
1w8b	Factor7 - 413 complex
1xdt	COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR
1xfe	Solution structure of the LA7-EGFA pair from the LDL receptor
1ygc	Short Factor VIIa with a small molecule inhibitor
1yo8	Structure of the C-terminal domain of human thrombospondin-2
1yuf	TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 16 MODELS WITHOUT ENERGY MINIMIZATION
1yug	TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 15 MODELS AFTER ECEPP/3 ENERGY MINIMIZATION
1z1y	Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax
1z27	Crystal structure of Native Pvs25, an ookinete protein from Plasmodium vivax.
1z3g	Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8
1z6e	Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)
1zaq	FOURTH EGF-LIKE DOMAIN OF THROMBOMODULIN, NMR, 12 STRUCTURES
2adx	FIFTH EGF-LIKE DOMAIN OF THROMBOMODULIN (TMEGF5), NMR, MINIMIZED AVERAGE STRUCTURE
2ayl	2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen
2bmg	Crystal structure of factor Xa in complex with 50
2bok	Factor Xa - cation
2bq6	Crystal structure of factor Xa in complex with 21
2bq7	Crystal structure of factor Xa in complex with 43
2bqw	CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45
2bz6	Orally available Factor7a inhibitor
2d1j	Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide
2ddu	Crystal structure of the third repeat domain of reelin
2e26	Crystal structure of two repeat fragment of reelin
2ei6	FACTOR XA IN COMPLEX WITH THE INHIBITOR (-)-cis-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine
2ei7	FACTOR XA IN COMPLEX WITH THE INHIBITOR trans-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine
2ei8	FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-chloroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine
2fzz	Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one
2g00	Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide
2gd4	Crystal Structure of the Antithrombin-S195A Factor Xa-Pentasaccharide Complex
2gy5	Tie2 Ligand-Binding Domain Crystal Structure
2gy7	Angiopoietin-2/Tie2 Complex Crystal Structure
2i9a	Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)
2i9b	Crystal structure of ATF-urokinase receptor complex
2jkh	Factor Xa - cation inhibitor complex
2k2s	structure of the MIC1-GLD/MIC6-EGF complex from Toxoplasma gondii
2k2t	Epidermal growth Factor-like domain 2 from Toxoplasma gondii Microneme protein 6
2kv4	EGF
2m74	1H, 13C and 15N assignments of the four N-terminal domains of human fibrillin-1
2oye	Indomethacin-(R)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1
2oyu	Indomethacin-(S)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1
2p16	Factor Xa in Complex with the Inhibitor APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE
2p3f	Crystal structure of the factor Xa/NAP5 complex
2p3t	Crystal structure of human factor XA complexed with 3-Chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide
2p3u	Crystal structure of human factor XA complexed with 3-chloro-N-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1H-imidazol-2-yl)methyl]thiophene-2-carboxamide {Pfizer 320663}
2p93	Factor xa in complex with the inhibitor 5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide
2p94	Factor xa in complex with the inhibitor 3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclohexyl)-1H-indole-6-carboxamide
2p95	Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide
2pe4	Structure of Human Hyaluronidase 1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis
2phb	An Orally Efficacious Factor Xa Inhibitor
2pr3	Factor XA inhibitor
2puq	Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor
2q1j	The discovery of glycine and related amino acid-based factor xa inhibitors
2ra0	X-ray Structure of FXa in complex with 7-fluoroindazole
2rhp	The Thrombospondin-1 Polymorphism Asn700Ser Associated with Cornoary Artery Disease Causes Local and Long-Ranging Changes in Protein Structure
2rnl	Solution structure of the EGF-like domain from human Amphiregulin
2tgf	THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA
2vvc	Aminopyrrolidine Factor Xa inhibitor
2vvu	Aminopyrrolidine Factor Xa inhibitor
2vvv	Aminopyrrolidine-related triazole Factor Xa inhibitor
2vwl	Aminopyrrolidine Factor Xa inhibitor
2vwm	Aminopyrrolidine Factor Xa inhibitor
2vwn	Aminopyrrolidine Factor Xa inhibitor
2vwo	Aminopyrrolidine Factor Xa inhibitor
2w26	Fator Xa in complex with BAY59-7939
2w3i	Crystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2
2w3k	Crystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1
2wft	Crystal structure of the human HIP ectodomain
2wfx	Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog in the presence of calcium
2wg3	Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium
2wg4	Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium
2wph	factor IXa superactive triple mutant
2wpi	factor IXa superactive double mutant
2wpj	factor IXa superactive triple mutant, NaCl-soaked
2wpk	factor IXa superactive triple mutant, ethylene glycol-soaked
2wpl	factor IXa superactive triple mutant, EDTA-soaked
2wpm	factor IXa superactive mutant, EGR-CMK inhibited
2xbv	Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
2xbw	Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
2xbx	Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
2xby	Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
2xc0	Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
2xc4	Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
2xc5	Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
2y5f	FACTOR XA - CATION INHIBITOR COMPLEX
2y5g	FACTOR XA - CATION INHIBITOR COMPLEX
2y5h	FACTOR XA - CATION INHIBITOR COMPLEX
2ygo	WIF domain-EGF-like domain 1 of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine
2ygp	WIF domain-EGF-like domain 1 Met77Trp of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine
2ygq	WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine
3a7q	Structural basis for specific recognition of reelin by its receptors
3asi	Alpha-Neurexin-1 ectodomain fragment; LNS5-EGF3-LNS6
3bt1	Structure of urokinase receptor, urokinase and vitronectin complex
3bt2	Structure of urokinase receptor, urokinase and vitronectin complex
3c9a	High Resolution Crystal Structure of Argos bound to the EGF domain of Spitz
3ca7	High Resolution Crystal Structure of the EGF domain of Spitz
3cen	Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide
3cfw	L-selectin lectin and EGF domains
3cs7	FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(4-methoxyphenyl)-6-(4-(1-(pyrrolidin-1-ylmethyl)cyclopropyl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one
3e50	Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha
3egf	SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS
3f1s	Crystal structure of Protein Z complexed with protein Z-dependent inhibitor
3f6u	Crystal structure of human Activated Protein C (APC) complexed with PPACK
3fby	The crystal structure of the signature domain of cartilage oligomeric matrix protein.
3ffg	Factor XA in complex with the inhibitor (R)-6-(2'-((3- HYDROXYPYRROLIDIN-1-YL)METHYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE
3g5c	Structural and biochemical studies on the ectodomain of human ADAM22
3gis	Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin
3h5c	X-Ray Structure of Protein Z-Protein Z Inhibitor Complex
3ho3	Crystal structure of Hedgehog-interacting protein (HHIP)
3ho4	Crystal structure of Hedgehog-interacting protein (HHIP)
3ho5	Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
3hs5	X-ray crystal structure of arachidonic acid bound to the cyclooxygenase channel of cyclooxygenase-2
3hs6	X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
3hs7	X-ray crystal structure of docosahexaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
3iit	Factor XA in complex with a cis-1,2-diaminocyclohexane derivative
3kcg	Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
3kk6	Crystal Structure of Cyclooxygenase-1 in complex with celecoxib
3kl6	Discovery of Tetrahydropyrimidin-2(1H)-one derivative TAK-442: A potent, selective and orally active factor Xa inhibitor
3kqb	Factor xa in complex with the inhibitor n-(3-fluoro-2'- (methylsulfonyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-1h- pyrazole-5-carboxamide
3kqc	Factor xa in complex with the inhibitor 6-(2'- (methylsulfonyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-5,6- dihydro-1h-pyrazolo[3,4-c]pyridin-7(4h)-one
3kqd	Factor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biphenyl-4-yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyridin-7(4h)-one
3kqe	Factor xa in complex with the inhibitor 3-methyl-1-(3-(5- oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'- (pyrrolidin-1-ylmethyl)biphenyl-4-yl)-5,6-dihydro-1h- pyrazolo[3,4-c]pyridin-7(4h)-one
3krk	X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2
3lc3	Benzothiophene Inhibitors of Factor IXa
3lc5	Selective Benzothiophine Inhibitors of Factor IXa
3liw	Factor XA in complex with (R)-2-(1-ADAMANTYLCARBAMOYLAMINO)-3-(3-CARBAMIDOYL-PHENYL)-N-PHENETHYL-PROPIONIC ACID AMIDE
3ln0	Structure of compound 5c-S bound at the active site of COX-2
3ln1	Structure of celecoxib bound at the COX-2 active site
3ltf	Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz
3ltg	Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant
3m36	Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)
3m37	Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)
3mdl	X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2
3mqe	Structure of SC-75416 bound at the COX-2 active site
3n8v	Crystal Structure of Unoccupied Cyclooxygenase-1
3n8w	Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen
3n8x	Crystal Structure of Cyclooxygenase-1 in Complex with Nimesulide
3n8y	Structure of Aspirin Acetylated Cyclooxygenase-1 in Complex with Diclofenac
3n8z	Crystal Structure of Cyclooxygenase-1 in Complex with Flurbiprofen
3njp	The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling
3nt1	High resolution structure of naproxen:COX-2 complex.
3ntb	Structure of 6-methylthio naproxen analog bound to mCOX-2.
3ntg	Crystal structure of COX-2 with selective compound 23d-(R)
3olt	X-ray crystal structure of arachidonic acid bound to the cyclooxygenase channel of R513H murine COX-2
3olu	X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of R513H murine COX-2
3pgh	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, FLURBIPROFEN
3poy	Crystal Structure of the alpha-Neurexin-1 ectodomain, LNS 2-6
3q3k	Factor Xa in complex with a phenylenediamine derivative
3q7d	Structure of (R)-naproxen bound to mCOX-2.
3qcw	Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts
3qh0	X-ray crystal structure of palmitic acid bound to the cyclooxygenase channel of cyclooxygenase-2
3qmo	X-ray crystal structure of NS-398 bound to the cyclooxygenase channel of cyclooxygenase-2
3r05	Structure of neurexin 1 alpha (domains LNS1-LNS6), with splice insert SS3
3rr3	Structure of (R)-flurbiprofen bound to mCOX-2
3s2k	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.
3s8v	Crystal structure of LRP6-Dkk1 complex
3s8z	Crystal structure of LRP6-E3E4
3s94	Crystal structure of LRP6-E1E2
3sob	The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB
3soq	The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide
3sov	The structure of a beta propeller domain in complex with peptide S
3tgf	THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA
3tk5	Factor Xa in complex with D102-4380
3tk6	factor Xa in complex with D46-5241
3tzi	X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2
3u73	Crystal structure of stabilized human uPAR mutant in complex with ATF
3u7u	Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
3v64	Crystal Structure of agrin and LRP4
4a0p	Crystal structure of LRP6P3E3P4E4
4bdw	The structure of the FnI-EGF tandem domain of coagulation factor XII in complex with Holmium
4bdx	The structure of the FnI-EGF tandem domain of coagulation factor XII
4c16	4C16
4cox	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, INDOMETHACIN
4csy	4CSY
4dg6	Crystal structure of domains 1 and 2 of LRP6
4e1g	X-ray crystal structure of alpha-linolenic acid bound to the cyclooxygenase channel of cyclooxygenase-2
4fm5	X-ray structure of des-methylflurbiprofen bound to murine COX-2
4ish	Structure of FACTOR VIIA in complex with the inhibitor BMS-593214 also known as 2'-[(6R,6AR,11BR)-2-CARBAMIMIDOYL-6,6A,7,11B-TETRAHYDRO-5H-INDENO[2,1-C]QUINOLIN-6-YL]-5'-HYDROXY-4'-METHOXYBIPHENYL-4-CARBOXYLIC ACID
4isi	Structure of FACTOR VIIA in complex with the inhibitor (6S)-N-(4-CARBAMIMIDOYLBENZYL)-1-CHLORO-3-(CYCLOBUTYLAMINO)-8,8-DIETHYL-4-OXO-4,6,7,8-TETRAHYDROPYRROLO[1,2-A]PYRAZINE-6-CARBOXAMIDE
4jyu	Structure of factor VIIA in complex with the inhibitor (2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-N-(PHENYLSULFONYL)ETHANAMIDE
4jyv	Structure of factor VIIA in complex with the inhibitor (2R)-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-2-(ISOQUINOLIN-6-YLAMINO)-N-[(3-SULFAMOYLPHENYL)SULFONYL]ETHANAMIDE
4jzd	Structure of factor VIIA in complex with the inhibitor 2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
4jze	Structure of factor VIIA in complex with the inhibitor 2-{2-[(1-aminoisoquinolin-6-yl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
4jzf	Structure of factor VIIA in complex with the inhibitor 2-{2-[(3-carbamoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
4k0v	Structural basis for angiopoietin-1 mediated signaling initiation
4k24	Structure of anti-uPAR Fab ATN-658 in complex with uPAR
4m10	Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam
4m11	Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
4na9	Factor VIIa in complex with the inhibitor 3'-amino-5'-[(2s,4r)-6-carbamimidoyl-4-phenyl-1,2,3,4-tetrahydroquinolin-2-yl]biphenyl-2-carboxylic acid
4ng9	Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(3-sulfamoylbenzyl)ethanamide
4nga	Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide
4o1z	Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam
4otj	4OTJ
4oty	Crystal structure of lumiracoxib bound to the apo-mouse-cyclooxygenase-2
4ph9	4PH9
4rrw	4RRW
4rrx	4RRX
4rry	4RRY
4rrz	4RRZ
4rs0	4RS0
4rut	4RUT
4tgf	SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA
4x8s	4X8S
4x8t	4X8T
4x8u	4X8U
4x8v	4X8V
4xl1	4XL1
4xlw	4XLW
4yt6	4YT6
4yt7	4YT7
4yzu	4YZU
4z0k	4Z0K
4z0l	4Z0L
4z6a	4Z6A
4z80	4Z80
4z81	4Z81
4zae	4ZAE
4zxx	4ZXX
4zxy	4ZXY
5cox	UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)
5e8d	5E8D
5egm	5EGM
5f19	5F19
5f1a	5F1A
5fdq	5FDQ
5fww	5FWW
5i46	5I46
5ikq	5IKQ
5ikr	5IKR
5ikt	5IKT
5ikv	5IKV
5jvy	5JVY
5jvz	5JVZ
5jw1	5JW1
5k0h	5K0H
5kir	5KIR
5kn5	5KN5
5l2y	5L2Y
5l2z	5L2Z
5l30	5L30
6cox	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 IN I222 SPACE GROUP

Links (links to other resources describing this domain)

• INTERPRO: IPR000742
• PFAM: EGF
• PROSITE: EGF_1