The domain within your query sequence starts at position 3 and ends at position 36; the E-value for the EGF_like domain shown below is 2.79e0.

ADCHSITGSCTCAPGFMGEVCAVPCAAGTYGPNC

EGF_like

EGF domain, unclasssified subfamily

• SMART accession number: SM00001
• Description: -

There are 116150 EGF_like domains in 57116 proteins in SMART's nrdb database.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
19.93	map04512	ECM-receptor interaction
18.82	map04510	Focal adhesion
7.75	map05222	Small cell lung cancer
7.20	map04810	Regulation of actin cytoskeleton
5.17	map04330	Notch signaling pathway
4.98	map04514	Cell adhesion molecules (CAMs)
4.43	map04360	Axon guidance
2.21	map05060	Prion disease
2.03	map04670	Leukocyte transendothelial migration
1.66	map04320	Dorso-ventral axis formation
1.48	map04060	Cytokine-cytokine receptor interaction
1.48	map04012	ErbB signaling pathway
1.29	map05212	Pancreatic cancer
1.29	map04610	Complement and coagulation cascades
1.29	map04010	MAPK signaling pathway
1.29	map05215	Prostate cancer
1.29	map04340	Hedgehog signaling pathway
1.11	map05219	Bladder cancer
1.11	map05213	Endometrial cancer
1.11	map05010	Alzheimer's disease
1.11	map05214	Glioma
1.11	map05223	Non-small cell lung cancer
1.11	map04540	Gap junction
1.11	map05218	Melanoma
0.74	map00590	Arachidonic acid metabolism
0.74	map04640	Hematopoietic cell lineage
0.55	map00350	Tyrosine metabolism
0.55	map04310	Wnt signaling pathway
0.55	map00740	Riboflavin metabolism
0.55	map04916	Melanogenesis
0.55	map00310	Lysine degradation
0.55	map00950	Alkaloid biosynthesis I
0.55	map04650	Natural killer cell mediated cytotoxicity
0.37	map04350	TGF-beta signaling pathway
0.37	map04620	Toll-like receptor signaling pathway
0.18	map04520	Adherens junction
0.18	map05120	Epithelial cell signaling in Helicobacter pylori infection
0.18	map00910	Nitrogen metabolism
0.18	map04662	B cell receptor signaling pathway
0.18	map05220	Chronic myeloid leukemia
0.18	map04920	Adipocytokine signaling pathway
0.18	map00632	Benzoate degradation via CoA ligation
0.18	map00562	Inositol phosphate metabolism
0.18	map05050	Dentatorubropallidoluysian atrophy (DRPLA)
0.18	map04210	Apoptosis
0.18	map04910	Insulin signaling pathway
0.18	map04660	T cell receptor signaling pathway
0.18	map05221	Acute myeloid leukemia
0.18	map04930	Type II diabetes mellitus

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EGF_like domain which could be assigned to a KEGG orthologous group, and not all proteins containing EGF_like domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of EGF_like domains in PDB

PDB code	Title
1aut	HUMAN ACTIVATED PROTEIN C
1c5m	STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
1dan	COMPLEX OF ACTIVE SITE INHIBITED HUMAN BLOOD COAGULATION FACTOR VIIA WITH HUMAN RECOMBINANT SOLUBLE TISSUE FACTOR
1dva	Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA
1dx5	Crystal structure of the thrombin-thrombomodulin complex
1ezq	CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515
1f0r	CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815
1f0s	Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707
1fak	HUMAN TISSUE FACTOR COMPLEXED WITH COAGULATION FACTOR VIIA INHIBITED WITH A BPTI-MUTANT
1fax	COAGULATION FACTOR XA INHIBITOR COMPLEX
1g2l	FACTOR XA INHIBITOR COMPLEX
1g2m	FACTOR XA INHIBITOR COMPLEX
1hj7	NMR study of a pair of LDL receptor Ca2+ binding epidermal growth factor-like domains, 20 structures
1hz8	SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR
1i0u	SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR
1ioe	Human coagulation factor Xa in complex with M55532
1iqe	Human coagulation factor Xa in complex with M55590
1iqf	Human coagulation factor Xa in complex with M55165
1iqg	Human coagulation factor Xa in complex with M55159
1iqh	Human coagulation factor Xa in complex with M55143
1iqi	Human coagulation factor Xa in complex with M55125
1iqj	Human coagulation factor Xa in complex with M55124
1iqk	Human coagulation factor Xa in complex with M55113
1iql	Human coagulation factor Xa in complex with M54476
1iqm	Human coagulation factor Xa in complex with M54471
1iqn	Human coagulation factor Xa in complex with M55192
1ksn	Crystal Structure of Human Coagulation Factor XA Complexed with FXV673
1lpg	CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79.
1lpk	CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125.
1lpz	CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 41.
1lqd	CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45.
1n7d	Extracellular domain of the LDL receptor
1nfu	CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR132747
1nfw	CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR209685
1nfx	CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208944
1nfy	CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR200095
1o5d	Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
1p0s	Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R
1pfx	PORCINE FACTOR IXA
1w0y	tf7a_3771 complex
1w2k	tf7a_4380 complex
1wqv	Human Factor Viia-Tissue Factor Complexed with propylsulfonamide-D-Thr-Met-p-aminobenzamidine
1wss	Human Factor Viia-Tissue Factor in Complex with peprid mimetic inhibitor that has two charge groups in P2 and P4
1wtg	Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-biphenylalanine-Gln-p-aminobenzamidine
1wu1	Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine
1wun	Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-Trp-Gln-p-aminobenzamidine
1wv7	Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-5-propoxy-Trp-Gln-p-aminobenzamidine
1x7a	Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
1xka	FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID
1xkb	FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID
1z6j	Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
2a2q	Complex of Active-site Inhibited Human Coagulation Factor VIIa with Human Soluble Tissue Factor in the Presence of Ca2+, Mg2+, Na+, and Zn2+
2aei	Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid
2aer	Crystal Structure of Benzamidine-Factor VIIa/Soluble Tissue Factor complex.
2b7d	Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model
2b8o	Crystal Structure of Glu-Gly-Arg-Chloromethyl Ketone-Factor VIIa/Soluble Tissue Factor Complex
2bo2	EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium.
2boh	Crystal structure of factor Xa in complex with compound ""1""
2bou	EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium.
2box	EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium.
2c4f	crystal structure of factor VII.stf complexed with pd0297121
2cji	Crystal structure of a Human Factor Xa inhibitor complex
2e26	Crystal structure of two repeat fragment of reelin
2ec9	Crystal structure analysis of human Factor VIIa , Souluble tissue factor complexed with BCX-3607
2f9b	Discovery of Novel Heterocyclic Factor VIIa Inhibitors
2fir	Crystal structure of DFPR-VIIa/sTF
2flb	Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
2flr	Novel 5-Azaindole Factor VIIa Inhibitors
2gy5	Tie2 Ligand-Binding Domain Crystal Structure
2gy7	Angiopoietin-2/Tie2 Complex Crystal Structure
2h9e	Crystal Structure of FXa/selectide/NAPC2 ternary complex
2j2u	CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
2j34	CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
2j38	CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
2j4i	CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
2j94	CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
2j95	CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
2kl7	Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275
2uwl	Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa
2uwo	Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa
2uwp	Factor Xa inhibitor complex
2vh0	Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
2vh6	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs
2vj2	Human Jagged-1, domains DSL and EGFs1-3
2w2m	WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR
2w2n	WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR
2w2o	PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR
2w2p	PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR
2w2q	PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR
2wyg	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs
2wyj	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs
2x10	Crystal structure of the complete EphA2 ectodomain
2x11	Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain
2y7x	The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
2y7z	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
2y80	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
2y81	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
2y82	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
2zp0	Human factor viia-tissue factor complexed with benzylsulfonamide-D-ile-gln-P-aminobenzamidine
2zwl	Human factor viia-tissue factor complexed with highly selective peptide inhibitor
2zzu	Human Factor VIIA-Tissue Factor Complexed with ethylsulfonamide-D-5-(3-carboxybenzyloxy)-Trp-Gln-p-aminobenzamidine
3a7q	Structural basis for specific recognition of reelin by its receptors
3bps	PCSK9:EGF-A complex
3ela	Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor
3ens	Crystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate
3fl7	Crystal structure of the human ephrin A2 ectodomain
3gcw	PCSK9:EGFA(H306Y)
3gcx	PCSK9:EGFA (pH 7.4)
3hpt	Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine
3k9x	X-ray crystal structure of human fxa in complex with (S)-N-((2-METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL)ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE
3m0c	The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
3mbw	Crystal structure of the human ephrin A2 LBD and CRD domains in complex with ephrin A1
3mx0	Crystal Structure of EphA2 ectodomain in complex with ephrin-A5
3ooi	Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine
3p5b	The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
3p5c	The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
3s8v	Crystal structure of LRP6-Dkk1 complex
3s8z	Crystal structure of LRP6-E3E4
3sw2	X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide
3th2	Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
3th3	Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
3th4	Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
3v65	Crystal structure of agrin and LRP4 complex
3zyj	NetrinG1 in complex with NGL1
4a7i	Factor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor
4aqs	Laminin beta1 LN-LE1-4 structure
4bti	factor Xa in complex with the dual thrombin-FXa inhibitor 58.
4btt	factor Xa in complex with the dual thrombin-FXa inhibitor 31.
4btu	Factor Xa in complex with the dual thrombin-FXa inhibitor 57.
4bxs	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
4bxw	Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
4cbz	Notch ligand, Jagged-1, contains an N-terminal C2 domain
4cc0	Notch ligand, Jagged-1, contains an N-terminal C2 domain
4cc1	Notch ligand, Jagged-1, contains an N-terminal C2 domain
4d90	Crystal Structure of Del-1 EGF domains
4ibl	Rubidium Sites in Blood Coagulation Factor VIIa
4k0v	Structural basis for angiopoietin-1 mediated signaling initiation
4um8	4UM8
4um9	4UM9
4xbm	4XBM
4y6d	4Y6D
4y71	4Y71
4y76	4Y76
4y79	4Y79
4y7a	4Y7A
4y7b	4Y7B
4ylq	4YLQ
4yz8	4YZ8
4zh8	4ZH8
4zha	4ZHA
4zma	4ZMA
5bo1	5BO1
5fm9	5FM9
5fma	5FMA
5jb8	5JB8
5jb9	5JB9
5jba	5JBA
5jbb	5JBB
5jbc	5JBC
5lsu	5LSU