The domain within your query sequence starts at position 625 and ends at position 716; the E-value for the GED domain shown below is 6.1e-34.



Dynamin GTPase effector domain
SMART accession number:SM00302
Description: -
Interpro abstract (IPR003130):

Dynamin GTPase effector domain found in proteins related to dynamin.

Dynamin is a GTP-hydrolysing protein that is an essential participant in clathrin-mediated endocytosis by cells. It self-assembles into 'collars' in vivo at the necks of invaginated coated pits; the self-assembly of dynamin being coordinated by the GTPase domain. Mutation studies indicate that dynamin functions as a molecular regulator of receptor-mediated endocytosis [ (PUBMED:10206643) ].

GO function:GTPase activity (GO:0003924), GTP binding (GO:0005525)
Family alignment:
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There are 6230 GED domains in 6213 proteins in SMART's nrdb database.

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