The domain within your query sequence starts at position 882 and ends at position 968; the E-value for the GRAM domain shown below is 3.93e-12.
PKLLRPRLLPGEECVLDGLRVYLLPDGREEGVGGSGGGPALLPAEGAVFLTTYRVIFTGM PTDPLVGEQVVVRSFPVAALTKEKRIS
GRAMdomain in glucosyltransferases, myotubularins and other putative membrane-associated proteins |
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SMART accession number: | SM00568 |
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Description: | - |
Interpro abstract (IPR004182): | The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. It is normally about 70 amino acids in length. It is thought to be an intracellular protein-binding or lipid-binding signalling domain, which has an important function in membrane-associated processes. The structure of the GRAM domain is similar to that found in PH domains [ (PUBMED:11050430) ]. Mutations in the GRAM domain of myotubularins cause a muscle disease, which suggests that the domain is essential for the full function of the enzyme [ (PUBMED:11050430) ]. Myotubularin-related proteins are a large subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids [ (PUBMED:14690594) ]. |
Family alignment: |
There are 15261 GRAM domains in 12911 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
- Disease (disease genes where sequence variants are found in this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)