The domain within your query sequence starts at position 216 and ends at position 380; the E-value for the HDc domain shown below is 5.19e-7.

NPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTR
SDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGH
FQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRW

HDc

Metal dependent phosphohydrolases with conserved 'HD' motif.

• SMART accession number: SM00471
• Description: Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).
• Interpro abstract (IPR003607):

  This entry represents the HD domain, which is is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. It also represents a related phosphodiesterase (PDEase) domain that is found in eukaryotic 3',5'-cGMP phosphodiesterase ( EC 3.1.4.17 ), which is located in photoreceptor outer segments and it is light activated, playing a pivotal role in signal transduction.

There are 209505 HDc domains in 208022 proteins in SMART's nrdb database.

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Wolf YI, Aravind L, Grishin NV, Koonin EV
• Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events.
• Genome Res. 1999; 9: 689-710

Phylogenetic analysis of aminoacyl-tRNA synthetases (aaRSs) of all 20 specificities from completely sequenced bacterial, archaeal, and eukaryotic genomes reveals a complex evolutionary picture. Detailed examination of the domain architecture of aaRSs using sequence profile searches delineated a network of partially conserved domains that is even more elaborate than previously suspected. Several unexpected evolutionary connections were identified, including the apparent origin of the beta-subunit of bacterial GlyRS from the HD superfamily of hydrolases, a domain shared by bacterial AspRS and the B subunit of archaeal glutamyl-tRNA amidotransferases, and another previously undetected domain that is conserved in a subset of ThrRS, guanosine polyphosphate hydrolases and synthetases, and a family of GTPases. Comparison of domain architectures and multiple alignments resulted in the delineation of synapomorphies-shared derived characters, such as extra domains or inserts-for most of the aaRSs specificities. These synapomorphies partition sets of aaRSs with the same specificity into two or more distinct and apparently monophyletic groups. In conjunction with cluster analysis and a modification of the midpoint-rooting procedure, this partitioning was used to infer the likely root position in phylogenetic trees. The topologies of the resulting rooted trees for most of the aaRSs specificities are compatible with the evolutionary "standard model" whereby the earliest radiation event separated bacteria from the common ancestor of archaea and eukaryotes as opposed to the two other possible evolutionary scenarios for the three major divisions of life. For almost all aaRSs specificities, however, this simple scheme is confounded by displacement of some of the bacterial aaRSs by their eukaryotic or, less frequently, archaeal counterparts. Displacement of ancestral eukaryotic aaRS genes by bacterial ones, presumably of mitochondrial origin, was observed for three aaRSs. In contrast, there was no convincing evidence of displacement of archaeal aaRSs by bacterial ones. Displacement of aaRS genes by eukaryotic counterparts is most common among parasitic and symbiotic bacteria, particularly the spirochaetes, in which 10 of the 19 aaRSs seem to have been displaced by the respective eukaryotic genes and two by the archaeal counterpart. Unlike the primary radiation events between the three main divisions of life, that were readily traceable through the phylogenetic analysis of aaRSs, no consistent large-scale bacterial phylogeny could be established. In part, this may be due to additional gene displacement events among bacterial lineages. Argument is presented that, although lineage-specific gene loss might have contributed to the evolution of some of the aaRSs, this is not a viable alternative to horizontal gene transfer as the principal evolutionary phenomenon in this gene class.

• Aravind L, Koonin EV
• The HD domain defines a new superfamily of metal-dependent phosphohydrolases.
• Trends Biochem Sci. 1998; 23: 469-72

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the HDc domain.

Protein	Disease
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (P35913) (SMART)	OMIM:180072: Night blindness, congenital stationary, type 3 OMIM:163500: Retinitis pigmentosa, autosomal recessive

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
63.24	map00230	Purine metabolism
21.08	map02020	Two-component system - General
8.39	map04914	Progesterone-mediated oocyte maturation
2.74	map00760	Nicotinate and nicotinamide metabolism
1.72	map00240	Pyrimidine metabolism
0.39	map00260	Glycine, serine and threonine metabolism
0.39	map00970	Aminoacyl-tRNA biosynthesis
0.24	map00530	Aminosugars metabolism
0.24	map00740	Riboflavin metabolism
0.24	map00730	Thiamine metabolism
0.24	map00051	Fructose and mannose metabolism
0.16	map00791	Atrazine degradation
0.08	map00350	Tyrosine metabolism
0.08	map00251	Glutamate metabolism
0.08	map00903	Limonene and pinene degradation
0.08	map00650	Butanoate metabolism
0.08	map00620	Pyruvate metabolism
0.08	map00624	1- and 2-Methylnaphthalene degradation
0.08	map00120	Bile acid biosynthesis
0.08	map00471	D-Glutamine and D-glutamate metabolism
0.08	map00330	Arginine and proline metabolism
0.08	map00460	Cyanoamino acid metabolism
0.08	map00632	Benzoate degradation via CoA ligation
0.08	map00362	Benzoate degradation via hydroxylation

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with HDc domain which could be assigned to a KEGG orthologous group, and not all proteins containing HDc domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of HDc domains in PDB

PDB code	Title
1f0j	CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B
1mkd	crystal structure of PDE4D catalytic domain and zardaverine complex
1oyn	Crystal structure of PDE4D2 in complex with (R,S)-rolipram
1ptw	The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis
1q9m	Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
1rkp	Crystal structure of PDE5A1-IBMX
1ro6	Crystal structure of PDE4B2B complexed with Rolipram (R & S)
1ro9	CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP
1ror	CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP
1so2	CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR
1soj	CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX
1t9r	Catalytic Domain Of Human Phosphodiesterase 5A
1t9s	Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP
1taz	Catalytic Domain Of Human Phosphodiesterase 1B
1tb5	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP
1tb7	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With AMP
1tbb	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Rolipram
1tbf	Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil
1udt	Crystal structure of Human Phosphodiesterase 5 complexed with Sildenafil(Viagra)
1udu	Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)
1uho	Crystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra)
1vj7	Crystal structure of the bifunctional catalytic fragment of RelSeq, the RelA/SpoT homolog from Streptococcus equisimilis.
1xlx	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast
1xlz	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast
1xm4	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast
1xm6	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram
1xmu	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast
1xmy	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram
1xn0	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram
1xom	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast
1xon	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast
1xoq	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast
1xor	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine
1xos	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil
1xot	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil
1xoz	Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil
1xp0	Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil
1xx7	Conserved hypothetical protein from Pyrococcus furiosus Pfu-403030-001
1y2b	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2c	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2d	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-methoxy-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2e	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-amino-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2h	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 1-(2-chloro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
1y2j	Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
1y2k	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
1ynb	crystal structure of genomics APC5600
1yoy	Predicted coding region AF1432 from Archaeoglobus Fulgidus
1z1l	The Crystal Structure of the Phosphodiesterase 2A Catalytic Domain
1zkl	Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases
1zkn	Structure of PDE4D2-IBMX
2chm	Crystal structure of N2 substituted pyrazolo pyrimidinones - a flipped binding mode in PDE5
2cqz	Crystal Structure of PH0347 protein from Pyrococcus horikoshii OT3
2dqb	Crystal structure of dNTP triphosphohydrolase from Thermus thermophilus HB8, which is homologous to dGTP triphosphohydrolase
2fm0	Crystal structure of PDE4D in complex with L-869298
2fm5	Crystal structure of PDE4D2 in complex with inhibitor L-869299
2h40	Crystal structure of the catalytic domain of unliganded PDE5
2h42	Crystal structure of PDE5 in complex with sildenafil
2h44	Crystal structure of PDE5A1 in complex with icarisid II
2hd1	Crystal structure of PDE9 in complex with IBMX
2hek	Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.
2o08	CRYSTAL STRUCTURE OF A PUTATIVE HD SUPERFAMILY HYDROLASE (BH1327) FROM BACILLUS HALODURANS AT 1.90 A RESOLUTION
2o6i	Structure of an Enterococcus Faecalis HD Domain Phosphohydrolase
2o8h	Crystal structure of the catalytic domain of rat phosphodiesterase 10A
2ogi	Crystal structure of a putative metal dependent phosphohydrolase (sag1661) from streptococcus agalactiae serogroup v at 1.85 A resolution
2oun	crystal structure of PDE10A2 in complex with AMP
2oup	crystal structure of PDE10A
2ouq	crystal structure of PDE10A2 in complex with GMP
2our	crystal structure of PDE10A2 mutant D674A in complex with cAMP
2ous	crystal structure of PDE10A2 mutant D674A
2ouu	crystal structure of PDE10A2 mutant D674A in complex with cGMP
2ouv	crystal structure of pde10a2 mutant of D564N
2ouy	crystal structure of pde10a2 mutant D564A in complex with cAMP.
2ovv	Crystal structure of the catalytic domain of rat phosphodiesterase 10A
2ovy	Crystal structure of the catalytic domain of rat phosphodiesterase 10A
2paq	Crystal structure of the 5'-deoxynucleotidase YfbR
2par	Crystal structure of the 5'-deoxynucleotidase YfbR mutant E72A complexed with Co(2+) and TMP
2pau	Crystal structure of the 5'-deoxynucleotidase YfbR mutant E72A complexed with Co(2+) and dAMP
2pgs	Crystal structure of a putative deoxyguanosinetriphosphate triphosphohydrolase from Pseudomonas syringae pv. phaseolicola 1448A
2pjq	Crystal structure of Q88U62_LACPL from Lactobacillus plantarum. Northeast Structural Genomics target LpR71
2pq7	Crystal structure of predicted HD superfamily hydrolase (104161995) from uncultured Thermotogales bacterium at 1.45 A resolution
2pw3	Structure of the PDE4D-cAMP complex
2q14	Crystal structure of Phosphohydrolase (BT4208) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution
2qgs	Crystal structure of SE1688 protein from Staphylococcus epidermidis. Northeast Structural Genomics Consortium target SeR89
2qyk	Crystal structure of PDE4A10 in complex with inhibitor NPV
2qyl	Crystal structure of PDE4B2B in complex with inhibitor NPV
2qym	crystal structure of unliganded PDE4C2
2qyn	Crystal structure of PDE4D2 in complex with inhibitor NPV
2r8q	Structure of LmjPDEB1 in complex with IBMX
2wey	Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals
2y0j	Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors, part 2, Lead-optimisation.
2yy2	Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX
3b2r	Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil
3b57	Crystal structure of the Lin1889 protein (Q92AN1) from Listeria innocua. Northeast Structural Consortium target LkR65
3bg2	Crystal structure of deoxyguanosinetriphosphate triphosphohydrolase from Flavobacterium sp. MED217
3bjc	Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor
3ccg	Crystal structure of predicted HD superfamily hydrolase involved in NAD metabolism (NP_347894.1) from Clostridium acetobutylicum at 1.50 A resolution
3d3p	Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor
3djb	Crystal structure of a HD-superfamily hydrolase (BT9727_1981) from Bacillus thuringiensis, Northeast Structural Genomics Consortium Target BuR114
3dto	Crystal structure of the metal-dependent HD domain-containing hydrolase BH2835 from Bacillus halodurans, Northeast Structural Genomics Consortium Target BhR130.
3dy8	Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)
3dyl	human phosphdiesterase 9 substrate complex (ES complex)
3dyn	human phosphodiestrase 9 in complex with cGMP (Zn inhibited)
3dyq	human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP
3dys	human phosphodiestrase-5'GMP complex (EP), produced by soaking with 20mM cGMP+20 mM MnCl2+20 mM MgCl2 for 2 hours, and flash-cooled to liquid nitrogen temperature when substrate was still abudant.
3ecm	Crystal structure of the unliganded PDE8A catalytic domain
3ecn	Crystal structure of PDE8A catalytic domain in complex with IBMX
3frg	Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor
3g3n	PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one
3g45	Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988
3g4g	Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871
3g4i	Crystal structure of human phosphodiesterase 4d with d155871
3g4k	Crystal structure of human phosphodiesterase 4d with rolipram
3g4l	Crystal structure of human phosphodiesterase 4d with roflumilast
3g58	Crystal structure of human phosphodiesterase 4d with d155988/pmnpq
3gw7	Crystal structure of a metal-dependent phosphohydrolase with conserved HD domain (yedJ) from Escherichia coli in complex with nickel ions. Northeast Structural Genomics Consortium Target ER63
3gwt	Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor
3hc1	Crystal structure of HDOD domain protein with unknown function (NP_953345.1) from GEOBACTER SULFURREDUCENS at 1.90 A resolution
3hc8	Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.
3hdz	Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors
3hmv	Catalytic domain of human phosphodiesterase 4B2B in complex with a tetrahydrobenzothiophene inhibitor
3hqw	Discovery of novel inhibitors of PDE10A
3hqy	Discovery of novel inhibitors of PDE10A
3hqz	Discovery of novel inhibitors of PDE10A
3hr1	Discovery of novel inhibitors of PDE10A
3i8v	Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone
3iad	Crystal structure of human phosphodiesterase 4D with bound allosteric modulator
3iak	Crystal structure of human phosphodiesterase 4d (PDE4d) with papaverine.
3ibj	X-ray structure of PDE2A
3irh	Structure of an Enterococcus Faecalis HD-domain protein complexed with dGTP and dATP
3itm	Catalytic domain of hPDE2A
3itu	hPDE2A catalytic domain complexed with IBMX
3jab	3JAB
3jbq	3JBQ
3jsi	Human phosphodiesterase 9 in complex with inhibitor
3jsw	Human PDE9 in complex with selective inhibitor
3jwq	Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil
3jwr	Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.
3k3e	Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691
3k3h	Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691
3k4s	The structure of the catalytic domain of human PDE4d with 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
3kh1	Crystal structure of Predicted metal-dependent phosphohydrolase (ZP_00055740.2) from Magnetospirillum magnetotacticum MS-1 at 1.37 A resolution
3kkt	Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.
3lxg	Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3
3ly2	Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
3mzo	Crystal structure of a HD-domain phosphohydrolase (lin2634) from LISTERIA INNOCUA at 1.98 A resolution
3n3z	Crystal structure of PDE9A (E406A) mutant in complex with IBMX
3nqw	A metazoan ortholog of SpoT hydrolyzes ppGpp and plays a role in starvation responses
3nr1	A metazoan ortholog of SpoT hydrolyzes ppGpp and plays a role in starvation responses
3o0j	PDE4B In complex with ligand an2898
3o56	Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor
3o57	Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor
3qi3	Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691
3qi4	Crystal structure of PDE9A(Q453E) in complex with IBMX
3qpn	Structure of PDE10-inhibitor complex
3qpo	Structure of PDE10-inhibitor complex
3qpp	Structure of PDE10-inhibitor complex
3shy	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
3shz	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
3sie	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
3sk9	Crystal structure of the Thermus thermophilus cas3 HD domain
3skd	Crystal structure of the Thermus thermophilus cas3 HD domain in the presence of Ni2+
3sl3	Crystal structure of the apo form of the catalytic domain of PDE4D2
3sl4	Crystal structure of the catalytic domain of PDE4D2 with compound 10D
3sl5	Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d
3sl6	Crystal structure of the catalytic domain of PDE4D2 with compound 12c
3sl8	Crystal structure of the catalytic domain of PDE4D2 with compound 10o
3sn7	Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
3sni	Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
3snl	Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
3tge	A novel series of potent and selective PDE5 inhibitor1
3tgg	A novel series of potent and selective PDE5 inhibitor2
3tm8	Bd1817, a HDG"Y"P protein from Bdellovibrio bacteriovorus
3tmb	Bd1817, a HDG"Y"P protein from Bdellovibrio bacteriovorus
3tmc	Bd1817, a HDG"Y"P protein from Bdellovibrio bacteriovorus
3tmd	Bd1817, a HDG"Y"P protein from Bdellovibrio bacteriovorus
3tvx	The structure of PDE4A with pentoxifylline at 2.84A resolution
3u1n	Structure of the catalytic core of human SAMHD1
3ui7	Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia
3uuo	The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia
3v93	unliganded structure of TcrPDEC1 catalytic domain
3v94	TcrPDEC1 catalytic domain in complex with inhibitor wyq16
3v9b	Crystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1-[1-(3-Cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)-ethyl]-1H-pyrazl-3-yl}phenyl)acetamide
3w5e	Crystal structure of phosphodiesterase 4B in complex with compound 31e
3wd9	Crystal structure of phosphodiesterase 4B in complex with compound 10f
3wfo	tRNA processing enzyme (apo form 1)
3wfp	tRNA processing enzyme (apo form 2)
3wfq	tRNA processing enzyme complex 1
3wfr	tRNA processing enzyme complex 2
3wfs	tRNA processing enzyme complex 3
3wi2	Crystal structure of PDE10A in complex with inhibitor
3ws8	3WS8
3ws9	3WS9
3wyk	3WYK
3wyl	3WYL
3wym	3WYM
4ael	PDE10A in complex with the inhibitor AZ5
4ajd	Identification and structural characterization of PDE10 fragment inhibitors
4ajf	Identification and structural characterization of PDE10 fragment inhibitors
4ajg	Identification and structural characterization of PDE10 fragment inhibitors
4ajm	Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors
4bbx	Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia
4bzb	Crystal structure of the tetrameric dGTP-bound SAMHD1 mutant catalytic core
4bzc	Crystal structure of the tetrameric dGTP-bound wild type SAMHD1 catalytic core
4c1i	4C1I
4d08	4D08
4d09	4D09
4ddl	PDE10a Crystal Structure Complexed with Novel Inhibitor
4dff	The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia
4dmb	X-ray structure of human hepatitus C virus NS5A-transactivated protein 2 at the resolution 1.9A, Northeast Structural Genomics Consortium (NESG) Target HR6723
4e90	Human phosphodiesterase 9 in complex with inhibitors
4fcb	Potent and Selective Phosphodiesterase 10A Inhibitors
4fcd	Potent and Selective Phosphodiesterase 10A Inhibitors
4g2j	Human pde9 in complex with selective compound
4g2l	Human PDE9 in complex with selective compound
4g2w	Crystal structure of PDE5A in complex with its inhibitor
4g2y	Crystal structure of PDE5A complexed with its inhibitor
4gh6	Crystal structure of the PDE9A catalytic domain in complex with inhibitor 28
4heu	Crystal Structure of PDE10A with a biaryl ether inhibitor ((1-(3-(4-((1H-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4-yl)methanol)
4hf4	Crystal Structure of PDE10A with a biaryl ether inhibitor (1-(1-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl)ethanol)
4htx	Crystal structure of PDE2 catalytic domain in complex with BAY60-7550
4htz	Crystal structure of PDE2 catalytic domain in space group P1
4i15	Crystal structure of TbrPDEB1
4i9z	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
4ia0	Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
4jib	Crystal structure of of PDE2-inhibitor complex
4kp6	Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative
4l1j	Three dimensional structure of mutant D143A of human HD domain-containing protein 2, Northeast Structural Genomics Consortium (NESG) Target HR6723
4l7e	Three dimensional structure of mutant D78A of human HD domain-containing protein 2, Genomics Consortium (NESG) Target HR6723
4l7w	Crystal structure mutant H77A of human HD domain-containing protein 2, Genomics Consortium (NESG) Target HR6723
4lkq	Crystal structure of PDE10A2 with fragment ZT017
4llj	Crystal structure of PDE10A2 with fragment ZT214
4llk	Crystal structure of PDE10A2 with fragment ZT217
4llp	Crystal structure of PDE10A2 with fragment ZT401
4llx	Crystal structure of PDE10A2 with fragment ZT434
4lm0	Crystal structure of PDE10A2 with fragment ZT448
4lm1	Crystal structure of PDE10A2 with fragment ZT450
4lm2	Crystal structure of PDE10A2 with fragment ZT462
4lm3	Crystal structure of PDE10A2 with fragment ZT464
4lm4	Crystal structure of PDE10A2 with fragment ZT902
4lrl	Structure of an Enterococcus Faecalis HD-domain protein complexed with dGTP and dTTP
4mcw	Metallo-enzyme from P. marina
4md6	4MD6
4mdz	Metallo-enzyme from P. marina
4me4	Metallo-enzyme from P. marina
4mlm	Crystal Structure of PhnZ from uncultured bacterium HF130_AEPn_1
4mln	Crystal of PhnZ bound to (R)-2-amino-1-hydroxyethylphosphonic acid
4mrw	Crystal structure of PDE10A2 with fragment ZT0120 (7-chloroquinolin-4-ol)
4mrz	Crystal structure of PDE10A2 with fragment ZT0429 (4-methyl-3-nitropyridin-2-amine)
4ms0	Crystal structure of PDE10A2 with fragment ZT0443 (6-chloropyrimidine-2,4-diamine)
4msa	Crystal structure of PDE10A2 with fragment ZT0449 (5-nitro-1H-benzimidazole)
4msc	Crystal structure of PDE10A2 with fragment ZT1595 (2-[(quinolin-7-yloxy)methyl]quinoline)
4mse	Crystal structure of PDE10A2 with fragment ZT1597 (2-({[(2S)-2-methyl-2,3-dihydro-1,3-benzothiazol-5-yl]oxy}methyl)quinoline)
4msh	Crystal Structure of PDE10A2 with fragment ZT0143 ((2S)-4-chloro-2,3-dihydro-1,3-benzothiazol-2-amine)
4msn	Crystal structure of PDE10A2 with fragment ZT0451 (8-nitroquinoline)
4muw	Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor
4mvh	Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor
4myq	Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33
4mz7	Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
4n6w	X-Ray Crystal Structure of Citrate-bound PhnZ
4n71	X-Ray Crystal Structure of 2-amino-1-hydroxyethylphosphonate-bound PhnZ
4npv	4NPV
4npw	4NPW
4nw7	4NW7
4oew	4OEW
4oex	4OEX
4ogb	4OGB
4p0n	4P0N
4p1r	4P1R
4phl	4PHL
4phw	4PHW
4pm0	4PM0
4q7h	4Q7H
4qfx	4QFX
4qfy	4QFY
4qfz	4QFZ
4qg0	4QG0
4qg1	4QG1
4qg2	4QG2
4qg4	4QG4
4qge	4QGE
4qqw	4QQW
4qqx	4QQX
4qqy	4QQY
4qqz	4QQZ
4r8z	4R8Z
4rxo	4RXO
4rxp	4RXP
4rxq	4RXQ
4rxr	4RXR
4rxs	4RXS
4s1b	4S1B
4s1c	4S1C
4tnp	4TNP
4tnq	4TNQ
4tnr	4TNR
4tnx	4TNX
4tny	4TNY
4tnz	4TNZ
4to0	4TO0
4to1	4TO1
4to2	4TO2
4to3	4TO3
4to4	4TO4
4to5	4TO5
4to6	4TO6
4tpm	4TPM
4tpp	4TPP
4w1o	4W1O
4wcu	4WCU
4wn1	4WN1
4wzi	4WZI
4x0f	4X0F
4x9e	4X9E
4xds	4XDS
4xy2	4XY2
4y2b	4Y2B
4y86	4Y86
4y87	4Y87
4y8c	4Y8C
4yf1	4YF1
4yqh	4YQH
4ys7	4YS7
4zo5	4ZO5
4zwe	4ZWE
4zwg	4ZWG
5ao0	5AO0
5ao1	5AO1
5ao2	5AO2
5ao3	5AO3
5ao4	5AO4
5axp	5AXP
5axq	5AXQ
5b25	5B25
5b4k	5B4K
5b4l	5B4L
5b7i	5B7I
5c1w	5C1W
5c28	5C28
5c29	5C29
5c2a	5C2A
5c2e	5C2E
5c2h	5C2H
5dh4	5DH4
5dh5	5DH5
5dqv	5DQV
5dqw	5DQW
5ede	5EDE
5edg	5EDG
5edh	5EDH
5edi	5EDI
5gqh	5GQH
5i2r	5I2R
5ihy	5IHY
5k9r	5K9R
5tk6	5TK6
5tk7	5TK7
5tk8	5TK8
5tk9	5TK9
5tka	5TKA

Links (links to other resources describing this domain)

• INTERPRO: IPR003607