The domain within your query sequence starts at position 239 and ends at position 346; the E-value for the HintN domain shown below is 3.15e-29.

TFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAAHFRATFASHV
QPGQYVLVSGVPGLQPARVAAVSTHVALGSYAPLTRHGTLVVEDVVAS

HintN

Hint (Hedgehog/Intein) domain N-terminal region

• SMART accession number: SM00306
• Description: Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.
• Interpro abstract (IPR003587):

  Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [ (PUBMED:9489693) ].

  This entry represents the N-terminal region of the hint domain.

There are 10871 HintN domains in 9985 proteins in SMART's nrdb database.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the HintN domain.

Protein	Disease
Sonic hedgehog protein (Q15465) (SMART)	OMIM:600725: Holoprosencephaly-3 OMIM:142945:

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
23.24	map00240	Pyrimidine metabolism
23.24	map00230	Purine metabolism
16.20	map03030	DNA replication
16.20	map04340	Hedgehog signaling pathway
5.63	map00190	Oxidative phosphorylation
3.52	map03020	RNA polymerase
2.82	map00500	Starch and sucrose metabolism
1.41	map00520	Nucleotide sugars metabolism
1.41	map00053	Ascorbate and aldarate metabolism
1.41	map00040	Pentose and glucuronate interconversions
1.41	map00790	Folate biosynthesis
0.70	map05120	Epithelial cell signaling in Helicobacter pylori infection
0.70	map00251	Glutamate metabolism
0.70	map03022	Basal transcription factors
0.70	map00530	Aminosugars metabolism
0.70	map04115	p53 signaling pathway

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with HintN domain which could be assigned to a KEGG orthologous group, and not all proteins containing HintN domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of HintN domains in PDB

PDB code	Title
1am2	GYRA INTEIN FROM MYCOBACTERIUM XENOPI
1at0	17-KDA FRAGMENT OF HEDGEHOG C-TERMINAL AUTOPROCESSING DOMAIN
1dfa	CRYSTAL STRUCTURE OF PI-SCEI IN C2 SPACE GROUP
1dq3	CRYSTAL STRUCTURE OF AN ARCHAEAL INTEIN-ENCODED HOMING ENDONUCLEASE PI-PFUI
1ef0	CRYSTAL STRUCTURE OF PI-SCEI MINIPRECURSOR
1gpp	Crystal structure of the S.cerevisiae Homing Endonuclease PI-SceI Domain I
1jva	CRYSTAL STRUCTURE OF THE VMA1-DERIVED ENDONUCLEASE BEARING THE N AND C EXTEIN PROPEPTIDES
1lws	Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence
1lwt	Crystal structure of the intein homing endonuclease PI-SceI bound to its substrate DNA (Ca2+ free)
1mi8	2.0 Angstrom crystal structure of a DnaB intein from Synechocystis sp. PCC 6803
1um2	Crystal Structure of the Vma1-Derived Endonuclease with the Ligated Extein Segment
1vde	PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY
1zd7	1.7 Angstrom Crystal Structure Of Post-Splicing Form of a dnaE Intein from Synechocystis Sp. Pcc 6803
1zde	1.95 Angstrom Crystal Structure of a dnaE Intein Precursor from Synechocystis Sp. Pcc 6803
2cw7	Crystal structure of intein homing endonuclease II
2cw8	Crystal structure of intein homing endonuclease II
2imz	Crystal structure of Mtu recA intein splicing domain
2in0	crystal structure of Mtu recA intein splicing domain
2in8	crystal structure of Mtu recA intein, splicing domain
2in9	crystal structure of Mtu recA intein, splicing domain
2jmz	Solution structure of a KlbA intein precursor from Methanococcus jannaschii
2jnq	Solution Structure of a KlbA Intein Precursor from Methanococcus jannaschii
2keq	Solution structure of DnaE intein from Nostoc punctiforme
2l8l	Structure of an engineered splicing intein mutant based on Mycobacterium tuberculosis RecA
2lcj	Solution NMR structure of Pab PolII Intein
2lqm	Solution Structures of RadA intein from Pyrococcus horikoshii
2lwy	Solution Structure of Bacterial Intein-Like domain from Clostridium thermocellum
3ifj	Crystal structure of Mtu recA intein, splicing domain
3igd	Crystal structure of Mtu recA intein, splicing domain
3nzm	Crystal structure of DNAE intein with N-extein in redox trap
4e2t	Crystal Structures of RadA intein from Pyrococcus horikoshii
4e2u	Crystal Structures of RadAmin intein from Pyrococcus horikoshii
4gig	crystal structure of T69A mutant of trapped Dnae intein precursor
4kl5	Crystal structure of NpuDnaE intein
4kl6	Crystal structure of dimeric form of NpuDnaE intein
4lx3	4LX3
4o1r	Crystal structure of NpuDnaB intein
4o1s	Crystal structure of TvoVMA intein
4oz6	Structure of the Branched Intermediate in Protein Splicing
4qfq	4QFQ
5i0a	5I0A
5k08	5K08

Links (links to other resources describing this domain)

• PFAM: Hint
• INTERPRO: IPR003587