The domain within your query sequence starts at position 173 and ends at position 253; the E-value for the IGc2 domain shown below is 7.41e-7.

VVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLY
IRNVTFEDAGEYTCLAGNSIG

IGc2

Immunoglobulin C-2 Type

• SMART accession number: SM00408
• Description: -
• Interpro abstract (IPR003598):

  The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; IPR013106 ), C1-set (constant-1; IPR003597 ), C2-set (constant-2; IPR008424 ) and I-set (intermediate; IPR013098 ) [ (PUBMED:9417933) ]. Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns [ (PUBMED:15327963) (PUBMED:11377196) ].

  Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system [ (PUBMED:10698639) ].

  This entry represents a subtype of the immunoglobulin domain, and is found in a diverse range of protein families that includes glycoproteins, fibroblast growth factor receptors, vascular endothelial growth factor receptors, interleukin-6 receptor, and neural cell adhesion molecules. It also includes proteins that are classified as unassigned proteinase inhibitors belonging to MEROPS inhibitor families I2, I17 and I43 [ (PUBMED:14705960) ].

There are 363480 IGc2 domains in 114582 proteins in SMART's nrdb database.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the IGc2 domain.

Protein	Disease
Low affinity immunoglobulin gamma Fc region receptor III-A (P08637) (SMART)	OMIM:146740: {Lupus erythematosus, systemic, susceptibility} OMIM:152700: Neutropenia, alloimmune neonatal ; {Viral infections, recurrent}
Netrin receptor DCC (P43146) (SMART)	OMIM:120470: Colorectal cancer
Fibroblast growth factor receptor 2 (P21802) (SMART)	OMIM:176943: Crouzon syndrome OMIM:123500: Jackson-Weiss syndrome OMIM:123150: Beare-Stevenson cutis gyrata syndrome OMIM:123790: Pfeiffer syndrome OMIM:101600: Apert syndrome OMIM:101200: Saethre-Chotzen syndrome
Low affinity immunoglobulin gamma Fc region receptor II-a (P12318) (SMART)	OMIM:146790: {Lupus nephritis, susceptibility to}
Myosin-binding protein C, cardiac-type (Q14896) (SMART)	OMIM:600958: Cardiomyopathy, familial hypertrophic, 4 OMIM:115197:
Neural cell adhesion molecule L1 (P32004) (SMART)	OMIM:308840: Hydrocephalus due to aqueductal stenosis OMIM:307000: MASA syndrome OMIM:303350: Spastic paraplegia OMIM:312900:

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
19.92	map04514	Cell adhesion molecules (CAMs)
9.21	map04060	Cytokine-cytokine receptor interaction
7.59	map04360	Axon guidance
7.18	map04810	Regulation of actin cytoskeleton
6.23	map04640	Hematopoietic cell lineage
6.10	map04510	Focal adhesion
4.88	map04670	Leukocyte transendothelial migration
3.79	map05215	Prostate cancer
2.98	map04520	Adherens junction
2.85	map04662	B cell receptor signaling pathway
2.85	map04660	T cell receptor signaling pathway
2.57	map05120	Epithelial cell signaling in Helicobacter pylori infection
2.57	map04020	Calcium signaling pathway
2.57	map04010	MAPK signaling pathway
2.57	map05218	Melanoma
1.90	map05210	Colorectal cancer
1.22	map04370	VEGF signaling pathway
1.22	map05214	Glioma
1.22	map04540	Gap junction
1.08	map05219	Bladder cancer
1.08	map04012	ErbB signaling pathway
0.95	map04916	Melanogenesis
0.95	map04530	Tight junction
0.95	map04620	Toll-like receptor signaling pathway
0.95	map04940	Type I diabetes mellitus
0.95	map05221	Acute myeloid leukemia
0.81	map04910	Insulin signaling pathway
0.54	map00940	Phenylpropanoid biosynthesis
0.54	map04512	ECM-receptor interaction
0.54	map00680	Methane metabolism
0.54	map04664	Fc epsilon RI signaling pathway
0.54	map00360	Phenylalanine metabolism
0.14	map04650	Natural killer cell mediated cytotoxicity

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with IGc2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing IGc2 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of IGc2 domains in PDB

PDB code	Title
1bih	CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION
1cs6	N-TERMINAL FRAGMENT OF AXONIN-1 FROM CHICKEN
1cvs	CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
1djs	LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1
1e07	Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
1e0o	Crystal structure of a ternary FGF1-FGFR2-heparin complex
1epf	CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)
1ev2	CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
1evt	CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
1f2q	CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR
1f42	THE P40 DOMAIN OF HUMAN INTERLEUKIN-12
1f45	HUMAN INTERLEUKIN-12
1f6a	Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)
1fhg	HIGH RESOLUTION REFINEMENT OF TELOKIN
1fq9	CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
1gl4	Nidogen-1 G2/Perlecan IG3 Complex
1h5b	T cell receptor Valpha11 (AV11S5) domain
1ie5	NMR STRUCTURE OF THE THIRD IMMUNOGLOBULIN DOMAIN FROM THE NEURAL CELL ADHESION MOLECULE.
1ii4	CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
1iil	CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
1j86	HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), MONOCLINIC CRYSTAL FORM 2
1j87	HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), HEXAGONAL CRYSTAL FORM 1
1j88	HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), TETRAGONAL CRYSTAL FORM 1
1j89	HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), TETRAGONAL CRYSTAL FORM 2
1jbj	CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct
1koa	TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
1l6z	CRYSTAL STRUCTURE OF MURINE CEACAM1A[1,4]: A CORONAVIRUS RECEPTOR AND CELL ADHESION MOLECULE IN THE CEA FAMILY
1n26	Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain
1nct	TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR
1ncu	TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR
1nun	Crystal Structure Analysis of the FGF10-FGFR2b Complex
1qz1	Crystal Structure of the Ig 1-2-3 fragment of NCAM
1rhf	Crystal Structure of human Tyro3-D1D2
1rpq	High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display
1ry7	Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
1sy6	Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment
1tlk	X-RAY STRUCTURE DETERMINATION OF TELOKIN, THE C-TERMINAL DOMAIN OF MYOSIN LIGHT CHAIN KINASE, AT 2.8 ANGSTROMS RESOLUTION
1tnm	TERTIARY STRUCTURE OF AN IMMUNOGLOBULIN-LIKE DOMAIN FROM THE GIANT MUSCLE PROTEIN TITIN: A NEW MEMBER OF THE I SET
1tnn	TERTIARY STRUCTURE OF AN IMMUNOGLOBULIN-LIKE DOMAIN FROM THE GIANT MUSCLE PROTEIN TITIN: A NEW MEMBER OF THE I SET
1u2h	X-ray Structure of the N-terminally truncated human APEP-1
1wvz	Solution Structure of the D2 Domain of the Fibroblast Growth Factor
1xiw	Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment
1xmw	CD3 EPSILON AND DELTA ECTODOMAIN FRAGMENT COMPLEX IN SINGLE-CHAIN CONSTRUCT
1ya5	Crystal structure of the titin domains z1z2 in complex with telethonin
2a38	Crystal structure of the N-Terminus of titin
2ckn	NMR Structure of the First Ig Module of mouse FGFR1
2cpc	Solution structure of RSGI RUH-030, an Ig like domain from human cDNA
2cr3	Solution structure of the first Ig-like domain of human fibroblast growth factor receptor 1
2d3v	Crystal Structure of Leukocyte Ig-like Receptor A5 (LILRA5/LIR9/ILT11)
2dl9	Solution structure of the Ig-like domain of human Leucine-rich repeat-containing protein 4
2dm2	Solution structure of the first ig domain of human palladin
2dm3	Solution structure of the second ig domain of human palladin
2dm7	Solution structure of the 14th Ig-like domain of human KIAA1556 protein
2e9w	Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)
2ec8	Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit
2edf	Solution structure of the second ig-like domain(2826-2915) from human Obscurin
2edj	Solution structure of the fifth ig-like domain from human Roundabout homolog 2
2edl	Solution structure of the ig-like domain (3801-3897) of human obscurin
2edw	Solution structure of the I-set domain (3537-3630) of human obscurin
2ens	Solution structure of the third ig-like domain from human Advanced glycosylation end product-specific receptor
2eo9	Solution structure of the fifth ig-like domain from human Roundabout homo1
2f8v	Structure of full length telethonin in complex with the N-terminus of titin
2fdb	Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c
2id5	Crystal Structure of the Lingo-1 Ectodomain
2iep	Crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK
2jll	Crystal structure of NCAM2 IgIV-FN3II
2kkq	Solution NMR Structure of the Ig-like C2-type 2 Domain of Human Myotilin. Northeast Structural Genomics Target HR3158.
2le9	RAGEC2-S100A13 tetrameric complex
2lqr	NMR structure of Ig3 domain of palladin
2ncm	NEURAL CELL ADHESION MOLECULE, NMR, 20 STRUCTURES
2npl	NMR Structure of CARD d2 Domain
2o26	Structure of a class III RTK signaling assembly
2om5	N-Terminal Fragment of Human TAX1
2r15	Crystal structure of the myomesin domains 12 and 13
2rik	I-band fragment I67-I69 from titin
2rjm	3Ig structure of titin domains I67-I69 E-to-A mutated variant
2v5m	Structural basis for Dscam isoform specificity
2v5r	Structural basis for Dscam isoform specificity
2v5s	Structural basis for Dscam isoform specificity
2v5t	Crystal structure of NCAM2 Ig2-3
2v9q	First and second Ig domains from human Robo1
2v9r	First and second Ig domains from human Robo1 (Form 2)
2v9t	Complex between the second LRR domain of Slit2 and The first Ig domain from Robo1
2vaj	Crystal structure of NCAM2 Ig1 (I4122 cell unit)
2vr9	Drosophila Robo IG1-2 (tetragonal form)
2vra	Drosophila Robo IG1-2 (monoclinic form)
2wim	Crystal structure of NCAM2 IG1-3
2wp3	Crystal structure of the Titin M10-Obscurin like 1 Ig complex
2wv3	Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor
2wwk	Crystal structure of the Titin M10-Obscurin like 1 Ig F17R mutant complex
2wwm	Crystal structure of the Titin M10-Obscurin like 1 Ig complex in space group P1
2xy1	CRYSTAL STRUCTURE OF NCAM2 IG3-4
2xy2	CRYSTAL STRUCTURE OF NCAM2 IG1-2
2xyc	CRYSTAL STRUCTURE OF NCAM2 IGIV-FN3I
2y25	Crystal structure of the myomesin domains My11-My13
2y7q	The high-affinity complex between IgE and its receptor Fc epsilon RI
2yd1	Crystal structure of the N-terminal Ig1-2 module of Drosophila Receptor Protein Tyrosine Phosphatase DLAR
2yd2	Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Sigma
2yd3	Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Sigma
2yd4	Crystal structure of the N-terminal Ig1-2 module of Chicken Receptor Protein Tyrosine Phosphatase Sigma
2yd5	Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase LAR
2yd6	Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Delta
2yd7	Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Delta
2yd8	Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase LAR in complex with sucrose octasulphate
2yd9	Crystal structure of the N-terminal Ig1-3 module of Human Receptor Protein Tyrosine Phosphatase Sigma
2yr3	Solution structure of the fourth Ig-like domain from myosin light chain kinase, smooth muscle
3b43	I-band fragment I65-I70 from titin
3caf	Crystal Structure of hFGFR2 D2 Domain
3cu1	Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex
3d85	Crystal structure of IL-23 in complex with neutralizing FAB
3d87	Crystal structure of Interleukin-23
3dar	Crystal structure of D2 domain from human FGFR2
3dmk	Crystal structure of Down Syndrome Cell Adhesion Molecule (DSCAM) isoform 1.30.30, N-terminal eight Ig domains
3duh	Structure of Interleukin-23
3ejj	Structure of M-CSF bound to the first three domains of FMS
3euu	Crystal structure of the FGFR2 D2 domain
3grw	FGFR3 in complex with a Fab
3hmx	Crystal structure of ustekinumab FAB/IL-12 complex
3j6n	Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle
3j6o	Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle
3jxa	Immunoglobulin domains 1-4 of mouse CNTN4
3jz7	Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)
3k0w	Crystal structure of the tandem IG-like C2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1
3kld	PTPRG CNTN4 complex
3knb	Crystal structure of the titin C-terminus in complex with obscurin-like 1
3kvq	Crystal structure of VEGFR2 extracellular domain D7
3laf	Structure of DCC, a netrin-1 receptor
3lcy	Titin Ig tandem domains A164-A165
3mj7	Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR
3mjg	The structure of a platelet derived growth factor receptor complex
3mtr	Crystal structure of the Ig5-FN1 tandem of human NCAM
3ncm	NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES
3oj2	Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation
3ojm	Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation
3ojv	Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop
3p3y	Crystal structure of neurofascin homophilic adhesion complex in space group p6522
3p40	Crystal structure of neurofascin adhesion complex in space group p3221
3pqy	Crystal Structure of 6218 TCR in complex with the H2Db-PA224
3puc	Atomic resolution structure of titin domain M7
3pxh	Tandem Ig domains of tyrosine phosphatase LAR
3pxj	Tandem Ig repeats of Dlar
3qqn	The retinal specific CD147 Ig0 domain: from molecular structure to biological activity
3qr2	Wild type CD147 Ig0 domain
3qwr	Crystal structure of IL-23 in complex with an adnectin
3r08	Crystal structure of mouse cd3epsilon in complex with antibody 2C11 Fab
3r4d	Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor
3rjd	Crystal structure of Fc RI and its implication to high affinity immunoglobulin G binding
3s97	PTPRZ CNTN1 complex
3so5	Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution
3uto	Twitchin kinase region from C.elegans (Fn31-NL-kin-CRD-Ig26)
3v2a	VEGFR-2/VEGF-A COMPLEX STRUCTURE
3v6b	VEGFR-2/VEGF-E complex structure
3zyi	NetrinG2 in complex with NGL2
3zyj	NetrinG1 in complex with NGL1
3zyo	Crystal structure of the N-terminal leucine rich repeats and immunoglobulin domain of netrin-G ligand-3
4c4k	4C4K
4cbp	4CBP
4dkd	Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R
4exp	Structure of mouse Interleukin-34 in complex with mouse FMS
4grw	Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
4hwu	Crystal structure of the Ig-C2 type 1 domain from mouse Fibroblast growth factor receptor 2 (FGFR2) [NYSGRC-005912]
4j23	Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex
4kc3	Cytokine/receptor binary complex
4liq	4LIQ
4lp5	Crystal structure of the full-length human RAGE extracellular domain (VC1C2 fragment)
4oe8	4OE8
4ofp	Crystal Structure of SYG-2 D3-D4
4ofy	Crystal Structure of the Complex of SYG-1 D1-D2 and SYG-2 D1-D4
4og9	4OG9
4oqt	LINGO-1/Li81 Fab complex
4p2y	4P2Y
4pbv	4PBV
4pbw	4PBW
4pbx	4PBX
4rca	4RCA
4u7m	4U7M
4uow	4UOW
4w4o	4W4O
4wrl	4WRL
4wrm	4WRM
4wv1	4WV1
4x4m	4X4M
4x83	4X83
4x8x	4X8X
4x9b	4X9B
4x9f	4X9F
4x9g	4X9G
4x9h	4X9H
4x9i	4X9I
4xb7	4XB7
4xb8	4XB8
4xhq	4XHQ
4y61	4Y61
4ybh	4YBH
4yfc	4YFC
4yfd	4YFD
4yfg	4YFG
4yh6	4YH6
4yh7	4YH7
4zne	4ZNE
5aea	5AEA
5e4i	5E4I
5e5r	5E5R
5e5u	5E5U
5eo9	5EO9
5f1d	5F1D
5fm5	5FM5
5ftt	5FTT
5i99	5I99
5k6u	5K6U
5k6v	5K6V
5k6w	5K6W
5k6x	5K6X
5k6y	5K6Y
5k6z	5K6Z
5k70	5K70

Links (links to other resources describing this domain)

• PFAM: ig
• INTERPRO: IPR003598