The domain within your query sequence starts at position 125 and ends at position 193; the E-value for the KH domain shown below is 6.8e-10.

SMALAPSVTSAPSMALAPSVTCAPCMAVAPSVTVAPSMALTPSVTLAPTMAVASSVAPGG
LPLLDPDVS

KH

K homology RNA-binding domain

• SMART accession number: SM00322
• Description: -
• Interpro abstract (IPR004087):

  The K homology (KH) domain was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety of nucleic acid-binding proteins. The KH domain binds RNA, and can function in RNA recognition [ (PUBMED:17437720) ]. It is found in multiple copies in several proteins, where they can function cooperatively or independently. For example, in the AU-rich element RNA-binding protein KSRP, which has 4 KH domains, KH domains 3 and 4 behave as independent binding modules to interact with different regions of the AU-rich RNA targets [ (PUBMED:17437720) ]. The solution structure of the first KH domain of FMR1 [ (PUBMED:9302998) ] and of the C-terminal KH domain of hnRNP K [ (PUBMED:10369774) ] determined by nuclear magnetic resonance (NMR) revealed a beta-alpha-alpha-beta-beta-alpha structure. Proteins containing KH domains include:

  • Bacterial and organelle PNPases [ (PUBMED:17337072) ].
  • Archaeal and eukaryotic exosome subunits [ (PUBMED:17159918) ].
  • Eukaryotic and prokaryotic RS3 ribosomal proteins [ (PUBMED:1160884) ].
  • Vertebrate fragile X mental retardation protein 1 (FMR1) [ (PUBMED:15805463) ].
  • Vigilin, which has 14 KH domains [ (PUBMED:14618268) ].
  • AU-rich element RNA-binding protein KSRP.
  • hnRNP K, which contains 3 KH domains.
  • Human onconeural ventral antigen-1 (NOVA-1) [ (PUBMED:10368286) ].

  According to structural analyses [ (PUBMED:9302998) (PUBMED:10369774) (PUBMED:11160884) ], the KH domain can be separated in two groups - type 1 and type 2.

• GO function: nucleic acid binding (GO:0003676)

There are 181505 KH domains in 115166 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Binding / catalysis: RNA-binding

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Lewis HA et al.
• Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome.
• Cell. 2000; 100: 323-32

The structure of a Nova protein K homology (KH) domain recognizing single-stranded RNA has been determined at 2.4 A resolution. Mammalian Nova antigens (1 and 2) constitute an important family of regulators of RNA metabolism in neurons, first identified using sera from cancer patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA). The structure of the third KH domain (KH3) of Nova-2 bound to a stem loop RNA resembles a molecular vise, with 5'-Ura-Cyt-Ade-Cyt-3' pinioned between an invariant Gly-X-X-Gly motif and the variable loop. Tetranucleotide recognition is supported by an aliphatic alpha helix/beta sheet RNA-binding platform, which mimics 5'-Ura-Gua-3' by making Watson-Crick-like hydrogen bonds with 5'-Cyt-Ade-3'. Sequence conservation suggests that fragile X mental retardation results from perturbation of RNA binding by the FMR1 protein.

• Adinolfi S, Bagni C, Musco G, Gibson T, Mazzarella L, Pastore A
• Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains.
• RNA. 1999; 5: 1248-58

FMR1 is an RNA-binding protein that is either absent or mutated in patients affected by the fragile X syndrome, the most common inherited cause of mental retardation in humans. Sequence analysis of the FMR1 protein has suggested that RNA binding is related to the presence of two K-homologous (KH) modules and an RGG box. However, no attempt has been so far made to map the RNA-binding sites along the protein sequence and to identify possible differential RNA-sequence specificity. In the present article, we describe work done to dissect FMR1 into regions with structurally and functionally distinct properties. A semirational approach was followed to identify four regions: an N-terminal stretch of 200 amino acids, the two KH regions, and a C-terminal stretch. Each region was produced as a recombinant protein, purified, and probed for its state of folding by spectroscopical techniques. Circular dichroism and NMR spectra of the N-terminus show formation of secondary structure with a strong tendency to aggregate. Of the two homologous KH motifs, only the first one is folded whereas the second remains unfolded even when it is extended both N- and C-terminally. The C-terminus is, as expected from its amino acid composition, nonglobular. Binding assays were then performed using the 4-nt homopolymers. Our results show that only the first KH domain but not the second binds to RNA, and provide the first direct evidence for RNA binding of both the N-terminal and the C-terminal regions. RNA binding for the N-terminus could not be predicted from sequence analysis because no known RNA-binding motif is identifiable in this region. Different sequence specificity was observed for the fragments: both the N-terminus of the protein and KH1 bind preferentially to poly-(rG). The C-terminal region, which contains the RGG box, is nonspecific, as it recognizes the bases with comparable affinity. We therefore conclude that FMR1 is a protein with multiple sites of interaction with RNA: sequence specificity is most likely achieved by the whole block that comprises the first approximately 400 residues, whereas the C-terminus provides a nonspecific binding surface.

• Ostareck-Lederer A, Ostareck DH, Hentze MW
• Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2.
• Trends Biochem Sci. 1998; 23: 409-11

• Musco G et al.
• The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome.
• Nat Struct Biol. 1997; 4: 712-6

• Musco G et al.
• Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome.
• Cell. 1996; 85: 237-45

The KH module is a sequence motif found in a number of proteins that are known to be in close association with RNA. Experimental evidence suggests a direct involvement of KH in RNA binding. The human FMR1 protein, which has two KH domains, is associated with fragile X syndrome, the most common inherited cause of mental retardation. Here we present the three-dimensional solution structure of the KH module. The domain consists of a stable beta alpha alpha beta beta alpha fold. On the basis of our results, we suggest a potential surface for RNA binding centered on the loop between the first two helices. Substitution of a well-conserved hydrophobic residue located on the second helix destroys the KH fold; a mutation of this position in FMR1 leads to an aggravated fragile X phenotype.

• Siomi H, Choi M, Siomi MC, Nussbaum RL, Dreyfuss G
• Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome.
• Cell. 1994; 77: 33-9

The KH domain is an evolutionarily conserved sequence motif present in many RNA-binding proteins, including the pre-mRNA-binding (hnRNP) K protein and the fragile X mental retardation gene product (FMR1). We assessed the role of KH domains in RNA binding by mutagenesis of KH domains in hnRNP K and FMR1. Conserved residues of all three hnRNP K KH domains are required for its wild-type RNA binding. Interestingly, while fragile X syndrome is usually caused by lack of FMR1 expression, a previously reported mutation in a highly conserved residue of one of its two KH domains (Ile-304-->Asn) also results in mental retardation. We found that the binding of this mutant protein to RNA is severely impaired. These results demonstrate an essential role for KH domains in RNA binding. Furthermore, they strengthen the connection between fragile X syndrome and loss of the RNA binding activity of FMR1.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the KH domain.

Protein	Disease
Synaptic functional regulator FMR1 (Q06787) (SMART)	OMIM:309550: Fragile X syndrome

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
34.62	map00240	Pyrimidine metabolism
34.62	map00230	Purine metabolism
29.68	map03010	Ribosome
1.00	map02010	ABC transporters - General
0.08	map00190	Oxidative phosphorylation

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with KH domain which could be assigned to a KEGG orthologous group, and not all proteins containing KH domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of KH domains in PDB

PDB code	Title
1dt4	CRYSTAL STRUCTURE OF NOVA-1 KH3 K-HOMOLOGY RNA-BINDING DOMAIN
1dtj	CRYSTAL STRUCTURE OF NOVA-2 KH3 K-HOMOLOGY RNA-BINDING DOMAIN
1e3h	SeMet derivative of Streptomyces antibioticus PNPase/GPSI enzyme
1e3p	tungstate derivative of Streptomyces antibioticus PNPase/GPSI enzyme
1ec6	CRYSTAL STRUCTURE OF NOVA-2 KH3 K-HOMOLOGY RNA-BINDING DOMAIN BOUND TO 20-MER RNA HAIRPIN
1fjg	STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE ANTIBIOTICS STREPTOMYCIN, SPECTINOMYCIN, AND PAROMOMYCIN
1hh2	Crystal structure of NusA from Thermotoga maritima
1hnw	STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE
1hnx	STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH PACTAMYCIN
1hnz	STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH HYGROMYCIN B
1hr0	CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT
1i94	CRYSTAL STRUCTURES OF THE SMALL RIBOSOMAL SUBUNIT WITH TETRACYCLINE, EDEINE AND IF3
1i95	CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH EDEINE
1i96	CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH THE TRANSLATION INITIATION FACTOR IF3 (C-TERMINAL DOMAIN)
1i97	CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH TETRACYCLINE
1ibk	STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE ANTIBIOTIC PAROMOMYCIN
1ibl	STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE AND WITH THE ANTIBIOTIC PAROMOMYCIN
1ibm	STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE
1j4w	COMPLEX OF THE KH3 and KH4 DOMAINS OF FBP WITH A SINGLE_STRANDED 29mer DNA OLIGONUCLEOTIDE FROM THE FUSE ELEMENT OF THE C-MYC ONCOGENE
1j5e	Structure of the Thermus thermophilus 30S Ribosomal Subunit
1j5k	COMPLEX OF THE KH3 DOMAIN OF HNRNP K WITH A SINGLE_STRANDED 10MER DNA OLIGONUCLEOTIDE
1jgo	The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGO, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY
1jgp	The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGP, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY
1jgq	The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGQ, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY
1k0r	Crystal Structure of Mycobacterium tuberculosis NusA
1k1g	STRUCTURAL BASIS FOR RECOGNITION OF THE INTRON BRANCH SITE RNA BY SPLICING FACTOR 1
1khm	C-TERMINAL KH DOMAIN OF HNRNP K (KH3)
1l2f	Crystal structure of NusA from Thermotoga maritima: a structure-based role of the N-terminal domain
1ml5	Structure of the E. coli ribosomal termination complex with release factor 2
1n32	Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position at the a site with paromomycin
1n33	Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin
1n34	Structure of the Thermus thermophilus 30S ribosomal subunit in the presence of codon and crystallographically disordered near-cognate transfer rna anticodon stem-loop mismatched at the first codon position
1n36	Structure of the Thermus thermophilus 30S ribosomal subunit in the presence of crystallographically disordered codon and near-cognate transfer RNA anticodon stem-loop mismatched at the second codon position
1tua	1.5 A Crystal Structure of a Protein of Unknown Function APE0754 from Aeropyrum pernix
1vig	NMR STUDY OF VIGILIN, REPEAT 6, 40 STRUCTURES
1vih	NMR STUDY OF VIGILIN, REPEAT 6, MINIMIZED AVERAGE STRUCTURE
1vvj	1VVJ
1vy4	1VY4
1vy5	1VY5
1vy6	1VY6
1vy7	1VY7
1we8	Solution structure of KH domain in protein BAB28342
1wvn	Crsytal Structure of domain 3 of human alpha polyC binding protein
1x4m	Solution structure of KH domain in Far upstream element binding protein 1
1x4n	Solution structure of KH domain in FUSE binding protein 1
1xmo	Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center
1xmq	Crystal Structure of t6A37-ASLLysUUU AAA-mRNA Bound to the Decoding Center
1xnq	Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center
1xnr	Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center
1ztg	human alpha polyC binding protein KH1
1zzi	Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA
1zzj	Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA
1zzk	Crystal Structure of the third KH domain of hnRNP K at 0.95A resolution
2ann	Crystal structure (I) of Nova-1 KH1/KH2 domain tandem with 25 nt RNA hairpin
2anr	Crystal structure (II) of Nova-1 KH1/KH2 domain tandem with 25nt RNA hairpin
2asb	Structure of a Mycobacterium tuberculosis NusA-RNA complex
2atw	Structure of a Mycobacterium tuberculosis NusA-RNA complex
2axy	Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA
2ba0	Archaeal exosome core
2bl5	Solution structure of the KH-QUA2 region of the Xenopus STAR-GSG Quaking protein.
2cpq	Solution structure of the N-terminal KH domain of human FXR1
2cte	Solution structure of the 1st KH type I domain from human Vigilin
2ctf	Solution structure of the 4th KH type I domain from human Vigilin
2ctj	Solution structure of the 8th KH type I domain from human Vigilin
2ctk	Solution structure of the 12th KH type I domain from human Vigilin
2ctl	Solution structure of the 13th KH type I domain from human Vigilin
2ctm	Solution structure of the 14th KH type I domain from human Vigilin
2cxc	Crystal structure of archaeal transcription termination factor NusA
2cy1	Crystal structure of APE1850
2dgr	Solution structure of the second KH domain in ring finger and KH domain containing protein 1
2e3u	Crystal structure analysis of Dim2p from Pyrococcus horikoshii OT3
2e5l	A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine- Dalgarno interaction
2f4v	30S ribosome + designer antibiotic
2fmr	KH1 FROM THE FRAGILE X PROTEIN FMR1, NMR, 18 STRUCTURES
2hh2	Solution structure of the fourth KH domain of KSRP
2hh3	Solution structure of the third KH domain of KSRP
2hhh	Crystal structure of kasugamycin bound to the 30S ribosomal subunit
2je6	Structure of a 9-subunit archaeal exosome
2jea	Structure of a 9-subunit archaeal exosome bound to RNA
2jeb	Structure of a 9-subunit archaeal exosome bound to Mn ions
2jvz	Solution NMR Structure of the Second and Third KH Domains of KSRP
2jzx	PCBP2 KH1-KH2 domains
2mjh	2MJH
2opu	Solution NMR Structure of the First Domain of KSRP
2opv	Solution NMR Structure of the Second Domain of KSRP
2p2r	Crystal structure of the third KH domain of human Poly(C)-Binding Protein-2 in complex with C-rich strand of human telomeric DNA
2pqu	Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer telomeric dna
2py9	Protein-RNA Interaction involving KH1 domain from Human Poly(C)-Binding Protein-2
2qnd	Crystal Structure of the KH1-KH2 domains from human Fragile X Mental Retardation Protein
2uu9	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUG-codon in the A-site and paromomycin.
2uua	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUC-codon in the A-site and paromomycin.
2uub	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUU-codon in the A-site and paromomycin.
2uuc	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUA-codon in the A-site and paromomycin.
2uxb	Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA GGGU in the context of the Thermus thermophilus 30S subunit.
2uxc	Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA UCGU in the context of the Thermus thermophilus 30S subunit.
2uxd	Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA CGGG in the context of the Thermus thermophilus 30S subunit.
2vqe	Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U-G wobble pairing during decoding
2vqf	Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U-G wobble pairing during decoding
2xr1	DIMERIC ARCHAEAL CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR WITH N-TERMINAL KH DOMAINS (KH-CPSF) FROM METHANOSARCINA MAZEI
2ycb	Structure of the archaeal beta-CASP protein with N-terminal KH domains from Methanothermobacter thermautotrophicus
2ykr	30S ribosomal subunit with RsgA bound in the presence of GMPPNP
2z0s	Crystal structure of putative exosome complex RNA-binding protein
2zm6	Crystal structure of the Thermus thermophilus 30S ribosomal subunit
3aev	Crystal structure of a/eIF2alpha-aDim2p-rRNA complex from Pyrococcus horikoshii OT3
3af5	The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii
3af6	The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii complexed with RNA-analog
3cdi	Crystal structure of E. coli PNPase
3gku	Crystal structure of a probable RNA-binding protein from Clostridium symbiosum ATCC 14940
3j6x	3J6X
3j6y	3J6Y
3j77	3J77
3j78	3J78
3j7a	3J7A
3j7p	3J7P
3j7r	3J7R
3j80	3J80
3j81	3J81
3j9w	3J9W
3j9y	3J9Y
3j9z	3J9Z
3ja1	3JA1
3jag	3JAG
3jah	3JAH
3jai	3JAI
3jaj	3JAJ
3jam	3JAM
3jan	3JAN
3jap	3JAP
3jaq	3JAQ
3jbn	3JBN
3jbo	3JBO
3jbp	3JBP
3jbu	3JBU
3jbv	3JBV
3jcd	3JCD
3jce	3JCE
3jcj	3JCJ
3jcn	3JCN
3krm	Imp1 kh34
3l7z	Crystal structure of the S. solfataricus archaeal exosome
3oto	Crystal Structure of the 30S ribosomal subunit from a KsgA mutant of Thermus thermophilus (HB8)
3t1h	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA lysine 3 (tRNALys3) bound to an mRNA with an AAA-codon in the A-site and Paromomycin
3t1y	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA Lysine 3 (TRNALYS3) bound to an mRNA with an AAG-codon in the A-site and paromomycin
3u1k	Crystal structure of human PNPase
3vke	Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides
4a2i	Cryo-electron Microscopy Structure of the 30S Subunit in Complex with the YjeQ Biogenesis Factor
4adv	Structure of the E. coli methyltransferase KsgA bound to the E. coli 30S ribosomal subunit
4aid	Crystal structure of C. crescentus PNPase bound to RNase E recognition peptide
4aim	Crystal structure of C. crescentus PNPase bound to RNase E recognition peptide
4am3	Crystal structure of C. crescentus PNPase bound to RNA
4aqy	Structure of ribsome-apramycin complexes
4b3m	Crystal structure of the 30S ribosome in complex with compound 1
4b3r	Crystal structure of the 30S ribosome in complex with compound 30
4b3s	Crystal structure of the 30S ribosome in complex with compound 37
4b3t	Crystal structure of the 30S ribosome in complex with compound 39
4b8t	RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.
4ba1	Archaeal exosome (Rrp4-Rrp41(D182A)-Rrp42) bound to inorganic phosphate
4ba2	Archaeal exosome (Rrp4-Rrp41(D182A)-Rrp42) bound to inorganic phosphate
4bsz	Crystal Structure of the Yeast Ribosomal Protein Rps3 in Complex with its Chaperone Yar1
4d5l	4D5L
4d61	4D61
4dr1	Crystal structure of the apo 30S ribosomal subunit from Thermus thermophilus (HB8)
4dr2	Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with multiple copies of paromomycin molecules bound
4dr3	Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with streptomycin bound
4dr4	Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, cognate transfer RNA anticodon stem-loop and multiple copies of paromomycin molecules bound
4dr5	Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered cognate transfer RNA anticodon stem-loop and streptomycin bound
4dr6	Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position and streptomycin bound
4dr7	Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered near-cognate transfer RNA anticodon stem-loop mismatched at the second codon position, and streptomycin bound
4duy	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U13C
4duz	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U13C, bound with streptomycin
4dv0	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U20G
4dv1	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, U20G, bound with streptomycin
4dv2	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, C912A
4dv3	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, C912A, bound with streptomycin
4dv4	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A914G
4dv5	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A914G, bound with streptomycin
4dv6	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A915G
4dv7	Crystal structure of the Thermus thermophilus 30S ribosomal subunit with a 16S rRNA mutation, A915G, bound with streptomycin
4gkj	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human mitochondrial anticodon stem loop (ASL) of transfer RNA Methionine (TRNAMET) bound to an mRNA with an AUG-codon in the A-site and paromomycin.
4gkk	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human mitochondrial anticodon stem loop (ASL) of transfer RNA Methionine (TRNAMET) bound to an mRNA with an AUA-codon in the A-site and paromomycin
4ji0	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji1	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji2	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji3	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji4	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji5	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji6	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji7	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4ji8	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
4jv5	Crystal structures of pseudouridinilated stop codons with ASLs
4jvh	Structure of the star domain of quaking protein in complex with RNA
4jvy	Structure of the STAR (signal transduction and activation of RNA) domain of GLD-1 bound to RNA
4jya	Crystal structures of pseudouridinilated stop codons with ASLs
4k0k	Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon
4khp	Structure of the Thermus thermophilus 30S ribosomal subunit in complex with de-6-MSA-pactamycin
4kvb	4KVB
4kzx	Rabbit 40S ribosomal subunit in complex with eIF1.
4kzy	Rabbit 40S ribosomal subunit in complex with eIF1 and eIF1A.
4kzz	Rabbit 40S ribosomal subunit in complex with mRNA, initiator tRNA and eIF1A
4l47	4L47
4l71	4L71
4lel	4LEL
4lf4	4LF4
4lf5	4LF5
4lf6	4LF6
4lf7	4LF7
4lf8	4LF8
4lf9	4LF9
4lfa	4LFA
4lfb	4LFB
4lfc	4LFC
4lfz	4LFZ
4lij	Crystal structure of a far upstream element (FUSE) binding protein 1 (FUBP1) from Homo sapiens at 1.95 A resolution
4lnt	4LNT
4lsk	4LSK
4lt8	4LT8
4mtn	Crystal structure of transcription termination factor NusA from Planctomyces limnophilus DSM 3776
4nbq	4NBQ
4nxm	Crystal Structure of the 30S ribosomal subunit from a GidB (RsmG) mutant of Thermus thermophilus (HB8)
4nxn	Crystal Structure of the 30S ribosomal subunit from a GidB (RsmG) mutant of Thermus thermophilus (HB8), bound with streptomycin
4ox9	Crystal structure of the aminoglycoside resistance methyltransferase NpmA bound to the 30S ribosomal subunit
4p6f	4P6F
4p70	4P70
4qmf	4QMF
4tua	4TUA
4tub	4TUB
4tuc	4TUC
4tud	4TUD
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Links (links to other resources describing this domain)

• PFAM: KH-domain
• INTERPRO: IPR004087